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Baseline And Stress-Induced Cognitive Control Deficits And Pro-Inflammatory Cytokines In Currently, Remitted, And Never Depressed Individuals, Katerina Rnic
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Background: Cognitive theories posit that cognitive control deficits promote depression by reducing ability to self-regulate under stress. When activated by stress and accessible to working memory, negative cognitive content and structure (i.e., schemas), may interfere with cognitive control abilities, resulting in even greater declines in executive functioning. Moreover, burgeoning evidence indicates that social stress upregulates inflammation, resulting in a pro-inflammatory phenotype that drives depression pathogenesis. However, cognitive mechanisms underlying this process are not well understood. An objective of this study was to examine depression-related deficits in cognitive control and their association with poor self-regulation. Another purpose was to evaluate the …