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Neuroanatomical Substrates Of The Disruptive Effect Of Olanzapine On Rat Maternal Behavior As Revealed By C-Fos Immunoreactivity, Changjiu Zhao, Ming Li

Department of Psychology: Faculty Publications

Olanzapine is one of the most widely prescribed atypical antipsychotic drugs in the treatment of schizophrenia. Besides its well-known side effect on weight gain, it may also impair human parental behavior. In this study, we took a preclinical approach to examine the behavioral effects of olanzapine on rat maternal behavior and investigated the associated neural basis using the c-Fos immunohistochemistry. On postpartum Days 6–8, Sprague-Dawley mother rats were given a single injection of sterile water or olanzapine (1.0, 3.0 or 5.0 mg/kg, sc). Maternal behavior was tested 2 h later, after which rats were sacrificed and brain tissues were collected. …

Spectrum Of Acute Clinical Characteristics Of Diagnosed Concussions In College Athletes Wearing Instrumented Helmets, Ann-Christine Duhaime,, Jonathan G. Beckwith, Arthur C. Maerlender, Thomas W. Mcallister, Joseph J. Crisco, Stefan M. Duma, P. Gunnar Brolinson, Steven Rowson, Laura A. Flashman, Jeffrey J. Chu, Richard M. Greenwald

Department of Psychology: Faculty Publications

Object. Concussive head injuries have received much attention in the medical and public arenas, as concerns have been raised about the potential shortand long-term consequences of injuries sustained in sports and other activities. While many student athletes have required evaluation after concussion, the exact definition of concussion has varied among disciplines and over time. The authors used data gathered as part of a multiinstitutional longitudinal study of the biomechanics of head impacts in helmeted collegiate athletes to characterize what signs, symptoms, and clinical histories were used to designate players as having sustained concussions.

Methods. Players on 3 college …

The Role Of Emotional Reactivity, Self-Regulation, And Puberty In Adolescents' Prosocial Behaviors, Gustavo Carlo, Lisa J. Crockett, Jennifer M. Wolff, Sarah J. Beal

Department of Psychology: Faculty Publications

This study was designed to examine the roles of emotional reactivity, self-regulation, and pubertal timing in prosocial behaviors during adolescence. Participants were 850 sixth graders (50% female, Mean age = 11.03, SD = .17) who were followed up at age 15. In hierarchical regression models, measures of emotional reactivity, self-regulation, pubertal timing and their interactions were used to predict (concurrently and over time) adolescents’ prosocial behaviors in the home and with peers. Overall, the findings provide evidence for pubertal and temperament based predictors of prosocial behaviors expressed in different contexts. Self-regulation was positively related to both forms of prosocial behavior, …

Serotonin System Gene Polymorphisms Are Associated With Impulsivity In A Context Dependent Manner, Scott F. Stoltenberg, Christa C. Christ, Krista B. Highland

Department of Psychology: Faculty Publications

Impulsivity is a risk factor for adverse outcomes and characterizes several psychiatric disorders and risk for suicide. There is strong evidence that genetic variation influences individual differences in impulsivity, but the details are not yet understood. There is growing interest in better understanding the context dependency of genetic effects that is reflected in studies examining gender specificity, gene × environment interaction and epistasis (gene-gene interaction). In a cross-sectional study we examined whether polymorphisms in six serotonin system candidate genes and the experience of early life trauma (age 0–12) were associated with individual differences in impulsivity in a nonclinical sample of …

Drug–Drug Conditioning Between Citalopram And Haloperidol Or Olanzapine In A Conditioned Avoidance Response Model: Implications For Polypharmacy In Schizophrenia, Nathan L. Sparkman, Ming Li

Department of Psychology: Faculty Publications

Patients with schizophrenia often have anxiety and depression, and thus are treated with multiple psychotherapeutic medications. This practice of polypharmacy increases the possibility for drug–drug interactions. However, the pharmacological and behavioral mechanisms underlying drug–drug interactions in schizophrenia remain poorly understood. In the present study, we adopted a preclinical approach and examined a less known behavioral mechanism, drug–drug conditioning (DDC) between haloperidol (a typical antipsychotic) or olanzapine (atypical antipsychotic) and citalopram (a selective serotonin reuptake inhibitor). A rat two-way conditioned avoidance response paradigm was used to measure antipsychotic activity and determine how DDC may alter the antipsychotic efficacy in this model. …

Correlates Of Same-Sex Attractions And Behaviors Among Self-Identified Heterosexual University Students, Luis F. Morales Knight, Debra A. Hope

Department of Psychology: Faculty Publications

Few studies have focused on intragroup variations in sexual orientation and fewer on self-identified heterosexuals with same-sex attractions, fantasies, and/or behaviors. Self-identified heterosexual students at a large public midwestern university (N = 263) completed measures of sexuality and gender, attitudes toward lesbian, gay, and bisexual (LGB) people, religious and political beliefs, emotional well-being, and demographics. The sample included 82 individuals (31%; labeled “H+”) who endorsed same-sex attraction, fantasy, and/or behavior and 181 (69%; labeled “H”) who did not. Women were more likely to be categorized as H+ than men. H+ participants had more positive attitudes toward lesbians and gay …

Parametric Studies Of Antipsychotic-Induced Sensitization In The Conditioned Avoidance Response Model: Roles Of Number Of Drug Exposure, Drug Dose, And Test–Retest Interval, Natashia Swalve, Ming Li

Department of Psychology: Faculty Publications

Repeated haloperidol and olanzapine treatment produces an enhanced disruption of avoidance responding, a validated measure of antipsychotic activity. Experimental parameters affecting this sensitization-like effect have not been thoroughly examined. The present study investigated the role of three parameters (number of injections, dose, and interval between initial exposure and challenge) in antipsychotic sensitization in the conditioned avoidance response paradigm. Well-trained Sprague–Dawley rats received different numbers of drug treatment (1–5 days) or different doses of haloperidol (0.025–0.10 mg/kg, subcutaneously) or olanzapine (0.5–2.0 mg/kg, subcutaneously). After certain time intervals (4, 10 or 17 days), they were tested for the expression of haloperidol or …

Effects Of Symptom Presentation Order On Perceived Disease Risk, Virginia S. Y. Kwan, Sean P. Wojcik, Talya Miron-Shatz, Ashley M. Votruba, Christopher Y. Olivola

Department of Psychology: Faculty Publications

People are quick to perceive meaningful patterns in the co-occurrence of events. We report two studies exploring the effects of streaks in symptom checklists on perceived personal disease risk. In the context of these studies, a streak is a sequence of consecutive items on a list that share the characteristic of being either general or specific. We identify a psychological mechanism underlying the effect of streaks in a list of symptoms and show that the effect of streaks on perceived risk varies with the length of the symptom list. Our findings reveal a tendency to infer meaning from streaks in …

The Historical, Jurisprudential, And Empirical Wisdom Of Parental Responsibility Laws, Eve M. Brank, Leroy Scott

Department of Psychology: Faculty Publications

The parent-child relationship is woven deep within historical and contemporary culture, but strong retributive ideals have led to blaming parents because of their presumed vicarious role in juvenile crime. The current article will discuss the history, forms, legal challenges, and empirical research related to parental involvement laws in the United States. The parent-child relationship provides the historical framework behind the separate juvenile justice parens patriae system; however, with the juvenile justice system not as successful as originally imagined, blame has shifted to the parents. We examine the potential constitutional implications of enacting and enforcing parental involvement statutes and ordinances and …

Discussion On The Paper By Neumann, Evett And Skerrett, Michael J. Saks, Ashley M. Votruba

Department of Psychology: Faculty Publications

Neumann, Evett, and Skerrett have made a major contribution to the art and science of fingerprint identification. This is an important—perhaps historic—step forward in the intellectual history of fingerprint identification and perhaps other fields of pattern matching forensic science. Their work deals ingeniously with the elusive problem of placing forensic identification on an empirically sound, quantitative foundation.

Bullying, Eve Brank, Lori Hoetger, Katherine Hazen

Department of Psychology: Faculty Publications

The effects of bullying on the bully and the victim can be wide reaching, impacting schoolwork, familial and peer relationships, psychological well-being, and physical health. As such, schools work to implement different intervention and prevention programs. Additionally, a variety of both criminal and civil legal interventions have recently been used to prevent or punish bullying. Most US states have enacted antibullying legislation that prohibits bullying behaviors, but definitional issues that are present in the empirical research are also present in such statutes. For instance, some states focus only on physical forms of bullying or leave definitions entirely up to individual …

Child Maltreatment Histories Among Female Inmate Reporting Inmate On Inmate Sexual Victimization In Prison: The Mediating Role Of Emotion Dysregulation, Kate Walsh, Valerie M. Gonsalves, Mario J. Scalora, Steve King, Patricia L. Hardyman

Department of Psychology: Faculty Publications

Despite data indicating that child maltreatment (CM) in various forms is associated with adult sexual victimization among community women, few studies have explicitly explored how types of CM might relate to prison sexual victimization. Because little is known about how CM might give rise to prison sexual victimization, the present study also examined emotion dysregulation emanating from early abuse experiences as a potential mediator in the link between early CM and inmate-on-inmate prison sexual victimization. Approximately 168 incarcerated women completed self-report inventories assessing various types of childhood maltreatment, emotion dysregulation, and coerced or forced sexual experiences in prison. Nearly 77% …

Reliability And Factor Structure Of The Psychological Maltreatment And Neglect Scales Of The Computer Assisted Maltreatment Inventory (Cami), Cindy L. Nash, Sarah A. Hayes-Skelton, David Dilillo

Department of Psychology: Faculty Publications

The primary objective of this study was to evaluate the psychometric properties of the Psychological Maltreatment (PM) and Neglect subscales of the Computer Assisted Maltreatment Inventory (CAMI; DiLillo et al., 2010). The CAMI is a retrospective self-report measure that assesses multiple forms of child maltreatment (i.e., sexual, physical, psychological, neglect, exposure to interparental violence) retrospectively from adults. The CAMI’s PM and Neglect subscales were administered to a geo-graphically diverse sample of 400 college students and a sample of 412 newlyweds. Exploratory fac-tor analyses were conducted for each group separately by subscale. Represented in the PM factor structures were items that …

Implicit And Explicit Alcohol-Related Motivations Among College Binge Drinkers, Laura C. Herschl, Dennis E. Mcchargue, James Mackillop, Scott F. Stoltenberg, Krista B. Highland

Department of Psychology: Faculty Publications

Rationale: Positive alcohol outcome expectancies and behavioral economic indices of alcohol consumption are related to binge drinking among college students and may reflect explicit and implicit motivations that are differentially associated with this behavior. Objectives: The present study hypothesized that implicit (alcohol purchase task) and explicit (positive expectancy for alcohol’s effects) motivations for drinking would not be correlated. It was also hypothesized that greater implicit and explicit motivations would predict alcohol-related risk. Methods: Participants were 297 college student binge drinkers (54% female; 88% European-American; Alcohol Use Disorders Identification Test: M = 9.53, SD = 5.04). Three indices from the …

Lifetime Sexual Victimization And Poor Risk Perception: Does Emotion Dysregulation Account For The Links?, Kate Walsh, David Dilillo, Terri L. Messman-Moore

Department of Psychology: Faculty Publications

The present study examined whether and which facets of emotion dysregulation serve an interven-ing role in the association between prior victimization and risk perception in an analogue sexual assault vignette. Participants were 714 university women who completed self-report measures of sexual victimization, emotion dysregulation, and a computer-administered written vignette of a col-lege party scene that culminates in acquaintance rape. Approximately 42% of the sample reported lifetime sexual victimization during childhood, adolescence, or adulthood. Two individual aspects of emotion dysregulation, limited access to emotion regulation strategies and impulse control diffi-culties, mediated the association between lifetime victimization and leaving the scenario later. …

Calendar Interviewing And The Use Of Landmark Events – Implications For Cross-Cultural Surveys, Tina Glasner, Wander Van Der Vaart, Robert F. Belli

Department of Psychology: Faculty Publications

This paper discusses potential methodological issues in the design and implementation of calendar recall aids such as the Life History Calendar for cross-cultural surveys. More specifically, it aims to provide insights into how the use of landmark events in calendar interviewing may be influenced by cross-cultural variability. As an example, we compare the landmark events reported by Dutch and American respondents in two studies in which calendar recall aids were used. The study discusses differences that were found between the two countries in the numbers and types of reported landmark events, as well as in the temporal distribution of those …

Clinical Phd Graduate Student Views Of Their Scientist-Practitioner Training, Joseph W. Vanderveen, L Felice Reddy, Jennifer C. Veilleux, Alicia M. January, David Dilillo

Department of Psychology: Faculty Publications

Objectives: The goal of the scientist-practitioner (S-P) training model is to produce clinical psycholo-gists equipped to integrate and utilize both science and practice in the clinical and research domains. However, much has been written regarding the possible shortcomings of S-P training and whether clinical psychology graduate students are actually gaining the knowledge and skills to integrate sci-ence and practice during graduate training and beyond (Chang, Lee, & Hargreaves, 2008; Gelso, 2006; Merlo, Collins, & Bernstein, 2008; Phillips, 1993). Methods: As such, the present study assessed ratings of satisfaction, perception of ability, and use of the S-P training model within 653 …

Conditioned Response Evoked By Nicotine Conditioned Stimulus Preferentially Induces C-Fos Expression In Medial Regions Of Caudate-Putamen, Sergios Charntikov, Matthew E. Tracy, Changjiu Zhao, Ming Li, Rick A. Bevins

Department of Psychology: Faculty Publications

Nicotine has both unconditioned and conditioned stimulus properties. Conditioned stimulus properties of nicotine may contribute to the tenacity of nicotine addiction. The purpose of this experiment was to use neurohistochemical analysis of rapidly developing c-Fos protein to elucidate neurobiological loci involved in the processing of nicotine as an interoceptive conditioned stimulus (CS). Rats were injected (SC) in an intermixed fashion with saline or nicotine (16 sessions of each) and placed in conditioning chambers where they were given one of the three conditions depending on group assignment: (a) nicotine paired 100% of the time with intermittent access to sucrose (nicotine-CS condition), …

Iptakalim Preferentially Decreases Nicotine-Induced Hyperlocomotion In Phencyclidine-Sensitized Rats: A Potential Dual Action Against Nicotine Addiction And Psychosis, Nick Volf, Gang Hu, Ming Li

Department of Psychology: Faculty Publications

Objective: Iptakalim is a putative ATP-sensitive potassium (KATP) channel opener. It is also a novel nicotinic acetylcholine receptor (nAChR) blocker and can antagonize nicotine-induced increase in dopamine release in the nucleus accumbens. Our recent work also shows that iptakalim exhibits a clozapine-like atypical antipsychotic profile, indicating that iptakalim may possess a dual action against nicotine addiction and schizophrenia.

Methods: The present study examined the potential therapeutic effects of iptakalim on nicotine use in schizophrenia. We created an animal model of comorbidity of nicotine addiction and schizophrenia by injecting male Sprague-Dawley rats with nicotine (0.40 mg/kg, subcutaneously［sc］) or saline, in combination …

Differential Effects Of Acute Amphetamine And Phencyclidine Treatment And Withdrawal From Repeated Amphetamine Or Phencyclidine Treatment On Social Interaction And Social Memory In Rats, Ming Li, Wei He, Rebecca Munro

Department of Psychology: Faculty Publications

Although animal models based on amphetamine (AMPH) or phencyclidine (PCP) treatment have been used extensively to study the neurobiological and behavioral characteristics of schizophrenia, there are conflicting reports regarding their validity in modeling the negative symptoms and cognitive deficits of schizophrenia. The present study examined how acute AMPH or PCP treatment (Experiment 1) and withdrawal from repeated AMPH treatment (Experiment 2) or PCP treatment (Experiment 3) affects social behavior and social recognition memory in male Sprague-Dawley rats. Each subject was tested on two consecutive days. On the first day, the rats were tested four times (5 min/each) at 10-min intervals …

The Processes Underlying Flexibility In Childhood, Lucy Cragg, Nicolas Chevalier

Department of Psychology: Faculty Publications

It is now well established in the adult literature that the ability to engage in flexible thought and action is a complex skill that relies on a number of underlying processes. The development of this skill has received growing interest in recent years. However, theories explaining children’s ability to switch between different tasks typically focus on a single underlying process and are rarely extended to explain development beyond the preschool years. This article reviews the current literature on set shifting in children in comparison with task switching in adults, in order to highlight the range of factors that impact on …

A Quantitative Analysis Of The Reward-Enhancing Effects Of Nicotine Using Reinforcer Demand, Scott T. Barrett, Rick A. Bevins

Department of Psychology: Faculty Publications

Reward enhancement by nicotine has been suggested as an important phenomenon contributing toward tobacco abuse and dependence. Reinforcement value is a multifaceted construct not fully represented by any single measure of response strength. The present study evaluated the changes in the reinforcement value of a visual stimulus in 16 male Sprague–Dawley rats using the reinforcer demand technique proposed by Hursh and Silberberg. The different parameters of the model have been shown to represent differing facets of reinforcement value, including intensity, perseverance, and sensitivity to changes in response cost. Rats lever-pressed for 1-min presentations of a compound visual stimulus over blocks …

Diminished Conditioned Responding To The Nicotine Stimulus By Antidepressant Drugs With Differing Specificity For The Serotonin And Norepinephrine Transporter, Amanda M. Dion, Scott C. Sanderson, L. Charles Murrin, Rick A. Bevins

Department of Psychology: Faculty Publications

People diagnosed with depression also tend to have a co-morbid nicotine addiction. Thus, there is interest in whether medications used to treat depression alter the effects of nicotine. This study assessed whether the antidepressant drugs citalopram, imipramine, and reboxetine, with differing specificity for the serotonin and norepinephrine transporter, altered responding controlled by the conditional stimulus (CS) effects of nicotine. Rats received intermixed 20-min nicotine (0.4 mg base/kg, SC) and saline sessions. On nicotine sessions, rats had intermittent access to sucrose; no sucrose was available on saline sessions. After discrimination performance stabilized and a nicotine generalization curve (0.025–0.4 mg/kg) was established, …

Association Between The Serotonin Transporter Triallelic Genotype And Eating Problems Is Moderated By The Experience Of Childhood Trauma In Women, Scott F. Stoltenberg, Cynthia Anderson, Parthasarathi Nag, Cheryl Anagnopoulos

Department of Psychology: Faculty Publications

Objective—This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors.

Methods—The study sample was comprised of 439 (64.7% female) Caucasian college students (mean age = 22.49, SD = 6.12). Participants completed questionnaires that assessed eating problems and experience of trauma in childhood (ages 0-12) and donated cheek cells for 5- HTTLPR and rs25531 genotyping.

Results—Women carrying a lower expressing allele (i.e. LG or S) who were exposed to higher levels of childhood trauma reported significantly higher mean numbers of eating …

The Political Left Rolls With The Good And The Political Right Confronts The Bad: Connecting Physiology And Cognition To Preferences, Michael D. Dodd, Amanda Balzer, Carly M. Jacobs, Michael W. Gruszczynski, Kevin B. Smith, John R. Hibbing

Department of Psychology: Faculty Publications

We report evidence that individual-level variation in people’s physiological and attentional responses to aversive and appetitive stimuli are correlated with broad political orientations. Specifically, we find that greater orientation to aversive stimuli tends to be associated with right-of-centre and greater orientation to appetitive (pleasing) stimuli with left-of-centre political inclinations. These findings are consistent with recent evidence that political views are connected to physiological predispositions but are unique in incorporating findings on variation in directed attention that make it possible to understand additional aspects of the link between the physiological and the political.

Neural Mechanisms Underlying Neurooptometric Rehabilitation Following Traumatic Brain Injury, Caitlin M. Hudac, Srinivas Kota, James L. Nedrow, Dennis L. Molfese

Department of Psychology: Faculty Publications

Mild to severe traumatic brain injuries have lasting effects on everyday functioning. Issues relating to sensory problems are often overlooked or not addressed until well after the onset of the injury. In particular, vision problems related to ambient vision and the magnocellular pathway often result in posttrauma vision syndrome or visual midline shift syndrome. Symptoms from these syndromes are not restricted to the visual domain. Patients commonly experience proprioceptive, kinesthetic, vestibular, cognitive, and language problems. Neurooptometric rehabilitation often entails the use of corrective lenses, prisms, and binasal occlusion to accommodate the unstable magnocellular system. However, little is known regarding the …

Conditioned Response Evoked By Nicotine Conditioned Stimulus Preferentially Induces C-Fos Expression In Medial Regions Of Caudate-Putamen, Sergios Charntikov, Matthew E. Tracy, Changjiu Zhao, Ming Li, Rick A. Bevins

Department of Psychology: Faculty Publications

Nicotine has both unconditioned and conditioned stimulus properties. Conditioned stimulus properties of nicotine may contribute to the tenacity of nicotine addiction. The purpose of this experiment was to use neurohistochemical analysis of rapidly developing c-Fos protein to elucidate neurobiological loci involved in the processing of nicotine as an interoceptive conditioned stimulus (CS). Rats were injected (SC) in an intermixed fashion with saline or nicotine (16 sessions of each) and placed in conditioning chambers where they were given one of the three conditions depending on group assignment: (a) nicotine paired 100% of the time with intermittent access to sucrose (nicotine-CS condition), …

Gender Differences In Head Impacts Sustained By Collegiate Ice Hockey Players, Lindley L. Brainard, Jonathan G. Beckwith, Jeffrey J. Chu, Joseph J. Crisco, Thomas W. Mcallister, Ann-Christine Duhaime,, Arthur C. Maerlender, Richard M. Greenwald

Department of Psychology: Faculty Publications

Purpose—This study aims to quantify the frequency, magnitude, and location of head impacts sustained by male and female collegiate ice hockey players over two seasons of play.

Methods—Over two seasons, 88 collegiate athletes (51 female, 37 male) on two female and male NCAA varsity ice hockey teams wore instrumented helmets. Each helmet was equipped with 6 single-axis accelerometers and a miniature data acquisition system to capture and record head impacts sustained during play. Data collected from the helmets were post-processed to compute linear and rotational acceleration of the head as well as impact location. The head impact exposure data (frequency, …

Disentangling The Nature Of The Nicotine Stimulus, Rick A. Bevins, Scott T. Barrett, Robert J. Polewan, Steven T. Pittenger, Natashia Swalve, Sergios Charntikov

Department of Psychology: Faculty Publications

Learning involving interoceptive stimuli likely plays an important role in many diseases and psychopathologies. Within this area, there has been extensive research investigating the interoceptive stimulus effects of abused drugs. In this pursuit, behavioral pharmacologists have taken advantage of what is known about learning processes and adapted the techniques to investigate the behavioral and receptor mechanisms of drug stimuli. Of particular interest is the nicotine stimulus and the use of the two-lever operant drug discrimination task and the Pavlovian drug discriminated goal-tracking task. There is strong concordance between the two methods when using “standard” testing protocols that minimize learning on …

Contributions Of Dynamic Systems Theory To Cognitive Development, John P. Spencer, Andrew Austin, Anne R. Schutte

Department of Psychology: Faculty Publications

This paper examines the contributions of dynamic systems theory to the field of cognitive development, focusing on modeling using dynamic neural fields. A brief overview highlights the contributions of dynamic systems theory and the central concepts of dynamic field theory (DFT). We then probe empirical predictions and findings generated by DFT around two examples—the DFT of infant perseverative reaching that explains the Piagetian A-not-B error, and the DFT of spatial memory that explain changes in spatial cognition in early development. A systematic review of the literature around these examples reveals that computational modeling is having an impact on empirical research …