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Antidepressant-Like Effects Of Amisulpride, Ketamine, And Their Enantiomers On Differential-Reinforcement-Of-Low-Rate (Drl) Operant Responding In Male C57/Bl/6 Mice, Doug Smith
Theses and Dissertations
Major depressive disorder (MDD) is a widespread psychiatric disorder that affects millions of people worldwide and is hypothesized to occur due to impairments in several neurotransmitter systems, including the monoaminergic and glutamatergic neurotransmitter systems. Antidepressant medications targeting multiple monoamine neurotransmitters have been shown to be effective for the treatment of depression. Racemic amisulpride is an atypical antipsychotic that has been used at low doses to treat dysthymia, a mild form of depression, and functions as an antagonist at DA2/3, 5-HT2B, and 5-HT7 receptors. Recent preclinical studies have suggested that the S(+) isomer may be more …
Establishing The Discriminative Stimulus Properties Of The Atypical Antipsychotic Amisulpride In C57bl/6 Mice, Timothy J. Donahue
Establishing The Discriminative Stimulus Properties Of The Atypical Antipsychotic Amisulpride In C57bl/6 Mice, Timothy J. Donahue
Theses and Dissertations
Abstract ESTABLISHING THE DISCRIMINATIVE STIMULUS PROPERTIES OF THE ATYPICAL ANTIPSYCHOTIC AMISULPRIDE IN C57BL/6 MICE Antipsychotic medications are used to treat schizophrenia. The present study used the drug discrimination paradigm to measure the subjective effects of the atypical antipsychotic amisulpride and to examine the underlying neuropharmacological mechanisms responsible for the discriminative stimulus property of the drug. Male C57BL/6 mice were trained to discriminate 10 mg/kg (-)S amisulpride from vehicle in a two-lever drug discrimination task. A dose effect curve for (-)S amisulpride yielded an ED50 = 1.77 mg/kg 95% CI [1.28, 2.45 mg/kg]. Substitution testing was conducted for the isomer (+)R …