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Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr.
Alterations To Taste Preference In Mc4r Haploinsufficiency Manifest Prior To Dietary Induced Obesity And Are Accompanied By Dendritic Spine Alterations To Medium Spiny Neurons Of The Nucleus Accumbens In Adulthood, Robert Francis Roscoe Jr.
Theses and Dissertations
Obesity has reached epidemic proportions in the United States and has become an increasing public health concern for developed nations. Haploinsufficiency of melanocortin receptor 4 has been identified as the single most common monogenetic cause of obesity in humans. Using the MC4R +/- haploinsufficient rat, we sought to determine potential alterations in body weight and morphology, locomotor activity, sucrose concentration preference, and progressive-ratio operant testing in a dietary-induced obesity environment. Rats were placed on four separate diets corresponding to 1.7% saturated fat with 12.2% total kcal/fat, 6% saturated fat with a 40% total kcal/fat, 12% saturated fat with a 40% …
Does Growth In Childhood Adhd And Depression Symptoms Predict Binge-Eating During Adolescence, Kathryn Van Eck
Does Growth In Childhood Adhd And Depression Symptoms Predict Binge-Eating During Adolescence, Kathryn Van Eck
Theses and Dissertations
Binge-eating disorder (BED) refers to experiencing a loss of control while eating high quantities of food in a short period of time. A serious public health concern, BED is highly comorbid with other psychological disorders and increases risk for obesity and other health concerns, such as metabolic disorder and diabetes. Little is known about what mental health symptoms contribute to the development of BED for children and adolescents. Research with adults indicates that two strong predictors of binge-eating behavior include impulsivity and depression, and these symptom areas may contribute to BED for youth, as well. In the current study, I …