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Alterations In Neurogenesis Following The Transition From Virgin To Maternal/Lactating Female, Elizabeth Amory

Master's Theses

The hippocampus displays hormone induced plasticity during estrus. Pregnancy, which exposes a female to a significantly longer duration of elevated estrogen and progesterone, results in even greater changes in neurons in the CA1 region of the hippocampus, with late-pregnant and lactating females displaying a significantly higher concentration of apical dendritic spines. Hippocampal astrocytes were increased in number and showed more and thicker processes in late-pregnant and lactating females. Such anatomical changes may also enhance spatial learning and memory. Changes in reproductive capacity may influence the rate at which new neurons are born, so called neurogenesis. In two experiments, neurogenesis in …