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Articles 1 - 8 of 8
Full-Text Articles in Entire DC Network
The Relationship Between P300 Evoked Potentials And Prefrontal Cortex Oxygen Use: A Combined Eeg And Nirs Study, Will S. Rizer
The Relationship Between P300 Evoked Potentials And Prefrontal Cortex Oxygen Use: A Combined Eeg And Nirs Study, Will S. Rizer
All NMU Master's Theses
The P300 subcomponent, P3b, is an event related potential detected at the scalp surface when a working memory comparison results in differences between the contents of working memory and incoming stimulus information. Previous research has indicated that as infrequent targets become more difficult to detect (morphologically similar to a frequent non-target stimulus) the P300 becomes attenuated. fMRI research has also indicated increased prefrontal cortex (PFC) activity during P300 generation. To examine the relationship between P3b amplitude and PFC activity participants performed an easy and difficult target detection task in both EEG and NIRS called the oddball. The EEG and behavioral …
The Neck As A Potential Site For Vestibular Tactile Sensory Substitution, Kelly A. Morrow
The Neck As A Potential Site For Vestibular Tactile Sensory Substitution, Kelly A. Morrow
All NMU Master's Theses
In order to determine if the neck could be used a site for vestibular-to-tactile sensory substitution, two experiments were performed to take an in-depth look of the tactile sensitivity of the neck and how it responds to vibrotactile stimuli. Experiment 1 explored how participants respond to a vibrotactile neck device, the Arraysense, and how well this device conveys information about a single contact point on the participant’s skin. Results showed that determining the exact point of stimulation is difficult for participants, but they can identify the area of stimulation with ease. Additionally, our results showed that the front of the …
Personality And Longevity In The Profession Of Athletic Training, Tyler Harris
Personality And Longevity In The Profession Of Athletic Training, Tyler Harris
All NMU Master's Theses
A survey was sent to 10,000 certified athletic trainers in various settings to examine personality characteristics and their relationship with satisfaction, intent to leave, and years practiced in the profession. The Employee Personality Inventory, included in the survey, separated respondents into five personality categories: communicators, directors, organizers, soothers and thinkers. Of the 1102 analyzed respondents, 216 were communicators, 51 were directors, 427 were organizers, 331 were soothers, and 77 were thinkers. The distribution of athletic training setting were as follows: academic instruction, 67; administration, 16; clinical medical, 53; clinical rehabilitation, 52; collegiate athletics, 331; high school athletics, 378; other, 65; …
Effects Of Optogenetic Activation And Pharmacological Modulation Of Dopamine Neurons, Remington J. Rice
Effects Of Optogenetic Activation And Pharmacological Modulation Of Dopamine Neurons, Remington J. Rice
All NMU Master's Theses
This study explored the use of optogenetic tools to better understand treatments used for schizophrenia. The “positive” symptoms (e.g., hallucinations, paranoia, etc.) of schizophrenia may come from overexpression of dopamine in mesolimbic dopamine neurons. Positive symptoms can be produced in healthy volunteers treated with amphetamine, a psychostimulant drug and dopamine releaser. Conversely, antipsychotic drugs may reduce positive symptoms by blocking dopamine receptors. This study used optogenetics to explore how drugs that alter neurotransmission, might alter behaviors occurring from activation of mesolimbic dopamine (DA) neurons in the ventral tegmental area (VTA). Light-induced activation of DA neurons in the VTA in male …
The History Of The Disease Concept Of Substance Dependency, Brooke A. Lewis
The History Of The Disease Concept Of Substance Dependency, Brooke A. Lewis
All NMU Master's Theses
The nomenclature used to signify substance dependence has evolved throughout history. Previously, substance dependence was referred to as specific forms of mania, as addiction, and as a habit. The origins of the disease concept of substance dependence have been disputed. Benjamin Rush (1746-1813) and Thomas Trotter (1760-1832) have been credited as being the founders of the movement to acknowledge substance dependence as a disease. Through efforts of scientists of the 19th and 20th centuries, the concept of substance dependence as a disease has become widely accepted by professionals, the medical community, and the government. Significant contributors to this concept include …
Assessment Of Neurotensin Receptor Agonist Effects On Fear-Potentiated Startle, Mark Aaron Vanden Avond
Assessment Of Neurotensin Receptor Agonist Effects On Fear-Potentiated Startle, Mark Aaron Vanden Avond
All NMU Master's Theses
Systemic administration of the NTS1 receptor agonist PD149163 has exhibited anxiolytic effects in male rats. The present study sought to further evaluate the potential anxiolytic effects of PD149163 by assessing this compound in both male and female C57BL/J6 mice using the fear-potentiated startle (FPS) paradigm. Startle chambers were equipped with a shock-grid floor, fluorescent light, and an acoustic startle speaker. Conditioning took place between the light and floor shock, and test sessions measured startle to a 90 dB noise burst while the light was on (FPS) or off. Startle magnitude did not differ between the male and female mice. …
The Universal Language, Amelia Richards
Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura Wise, Alan L. Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter
Discriminative Stimulus Properties Of 1.25 Mg/Kg Clozapine In Rats: Mediation By Serotonin 5-Ht2 And Dopamine D4 Receptors, Adam J. Prus, Laura Wise, Alan L. Pehrson, Scott D. Philibin, Benny Bang-Andersen, Jørn Arnt, Joseph H. Porter
Journal Articles
The atypical antipsychotic drug clozapine remains one of most effective treatments for schizophrenia, given a lack of extrapyramidal side effects, improvements in negative symptoms, cognitive impairment, and in symptoms in treatment-resistant schizophrenia. The adverse effects of clozapine, including agranulocytosis, make finding a safe clozapine-like a drug a goal for drug developers. The drug dis- crimination paradigm is a model of interoceptive stimulus that has been used in an effort to screen experimental drugs for clozapine-like atypical antipsychotic effects. The present study was conducted to elucidate the receptor-mediated stimulus properties that form this clozapine discriminative cue by testing selective receptor ligands …