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The Effect Of Substance P On Ovariectomy-Induced Memory Deficits In Rats, Jamie L. Haga
The Effect Of Substance P On Ovariectomy-Induced Memory Deficits In Rats, Jamie L. Haga
Theses, Dissertations and Capstones
The present experiment was designed to test whether pretreatment with substance P would affect ovariectomy-induced memory deficits in rats for retention in the Morris water maze. Adult female Sprague-Dawley rats were divided to two groups: (1) control (received saline) and (2) experimental group (received substance P). All rats underwent an ovariectomy, as this has been shown to significantly impair spatial reference learning and memory (Monteiro, Matté, Bavaresco, Netto, & Wyse, 2005). Approximately 8 months after surgery, all rats were trained in the Morris water maze in order to evaluate both reference and working memory. Results showed that substance P did …