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The Effects Of Adenosine Antagonists On Vigilant Attention In Sleep Restricted Rats, Morgan Crewe
The Effects Of Adenosine Antagonists On Vigilant Attention In Sleep Restricted Rats, Morgan Crewe
Masters Theses, 2010-2019
The relation between chronic sleep restriction and performance on the Psychomotor Vigilance Task (PVT) have been well documented in the human literature, with chronic sleep restriction as little as 7 hours per night resulting in significant impairment in sustained attention performance measured via the PVT. Recently, an analogous version of the human PVT has been developed for use with rodent models (rPVT). Recent studies have measured the effects of sleep restriction on rPVT performance, citing similar results found in the human literature. However, few studies to date have directly examined the role of adenosine accumulation during sleep deprivation in producing …
The Effects Of Chronic Partial Sleep Deprivation And Chronic Voluntary Alcohol Consumption On Δfos B Accumulation, Kristian Ponder
The Effects Of Chronic Partial Sleep Deprivation And Chronic Voluntary Alcohol Consumption On Δfos B Accumulation, Kristian Ponder
Masters Theses, 2010-2019
The present study explores the relation between sleep restriction and alcohol use and the neural substrates that result from chronic behaviors. Accumulation of the transcription factors ΔFosB is suggested as a possible outcome of chronic behaviors, such as addiction. Sleep is discussed as possible mediating factor in the relationship between ΔFosB and chronic alcohol consumption. There were four experimental groups in this study: Control (C), Sleep Deprivation only (SD), Alcohol Exposure only (AO), and both sleep deprivation and alcohol exposure (B). Levels of ΔFosB accumulation in the Nucleus Accumbens (NAc) revealed a significant main effect of sleep deprivation, but no …
Effects Of Chronic Marijuana Use On Circadian Rhythms, Sleep, And Cognitive Performance, Lauren Nicole Whitehurst
Effects Of Chronic Marijuana Use On Circadian Rhythms, Sleep, And Cognitive Performance, Lauren Nicole Whitehurst
Masters Theses, 2010-2019
Marijuana use has been linked to various circadian related activities like sleep and cognitive performance (Bolla et al., 2002; 2008; Budney et al., 2002; Cohen-Zion et al., 2010; Iverson et al., 2005; Meier et al., 2012; NIDA, 2012; Pope & Yugulen-Todd, 1996; WHO, 2013). Animal literature suggests a connection between marijuana use and altered circadian rhythms; however, the effect has not yet been studied in humans (Acuna-Goycolea et al., 2010; Sanford et al., 2008). The present study seeks to examine the effect of chronic marijuana use on circadian function in humans and extend the knowledge surrounding marijuana’s effect on neurocognition …