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Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced By Neonatal Quinpirole Treatment., Stephanie K. Thacker
Chronic Olanzapine Treatment Eliminates Cognitive Deficits Produced By Neonatal Quinpirole Treatment., Stephanie K. Thacker
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This study evaluated the effects of chronic olanzapine treatment on cognitive performance and neurochemical function in a rodent model of schizophrenia. Animals were neonatally treated with quinpirole, a dopamine D2 receptor agonist, or saline. Quinpirole treatment produces an increase of dopamine D2 receptor sensitivity that extends into adulthood, known as D2 receptor priming, similar to a phenomenon that occurs in schizophrenia. These same rats were treated in adulthood for 28 days with olanzapine, an atypical antipsychotic, or saline. Dopamine D2- primed rats demonstrated significant deficits on a cognitive task that were alleviated by olanzapine treatment. …