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Nitric Oxide Synthesis By Chicken Macrophages Results In Coordinated Changes Of Multiple Arginine Transporters, Michael Moulds
Nitric Oxide Synthesis By Chicken Macrophages Results In Coordinated Changes Of Multiple Arginine Transporters, Michael Moulds
Master's Theses
Arginine transport is primarily mediated by the cationic amino acid transporters (CATs) in mammalian cells, but in aves the y+, b0,+ and B0,+ transport systems have also been observed. Arginine is the limiting catabolic substrate required for the production of nitric oxide (NO), a highly reactive compound that acts as a signaling molecule or killing compound. NO is synthesized by inducible nitric oxide synthase (iNOS) by macrophages for pathogen clearance. In mammals, CAT-2B is responsible for ARG import in the macrophage for NO synthesis, but the chicken CAT-2B isoform does not transport ARG. Therefore the objective …