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In Ovo Serial Skeletal Muscle Diffusion Tractography Of The Developing Chick Embryo Using Dti: Feasibility And Correlation With Histology, Zien Zhou, Zachary Delproposto, Lianming Wu, Jianrong Xu, Jia Hua, Yan Zhou, Yongquan Ye, Zishu Zhang, Jiani Hu, E Mark Haacke
In Ovo Serial Skeletal Muscle Diffusion Tractography Of The Developing Chick Embryo Using Dti: Feasibility And Correlation With Histology, Zien Zhou, Zachary Delproposto, Lianming Wu, Jianrong Xu, Jia Hua, Yan Zhou, Yongquan Ye, Zishu Zhang, Jiani Hu, E Mark Haacke
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Magnetic resonance imaging is a noninvasive method of evaluating embryonic development. Diffusion tensor imaging (DTI), based on the directional diffusivity of water molecules, is an established method of evaluating tissue structure. Yet embryonic motion degrades the in vivo acquisition of long-duration DTI. We used a dual-cooling technique to avoid motion artifact and aimed to investigate whether DTI can be used to monitor chick embryonic skeletal muscle development in ovo, and to investigate the correlation between quantitative DTI parameters fractional anisotropy (FA) and fiber length and quantitative histologic parameters fiber area percentage (FiberArea%) and limb length.
Results
From 84 …
Homoplastic Microinversions And The Avian Tree Of Life, Edward L. Braun, Rebecca T. Kimball, Kin-Lan Han, Naomi R. Iuhasz-Velez, Amber J. Bonilla, Jena L. Chojnowski, Jordan V. Smith, Rauri Ck Bowie, Michael J. Braun, Shannon J. Hackett, John Harshman, Christopher J. Huddleston, Ben D. Marks, Kathleen J. Miglia, William S. Moore, Sushma Reddy, Frederick H. Sheldon, Christopher C. Witt, Tamaki Yuri
Homoplastic Microinversions And The Avian Tree Of Life, Edward L. Braun, Rebecca T. Kimball, Kin-Lan Han, Naomi R. Iuhasz-Velez, Amber J. Bonilla, Jena L. Chojnowski, Jordan V. Smith, Rauri Ck Bowie, Michael J. Braun, Shannon J. Hackett, John Harshman, Christopher J. Huddleston, Ben D. Marks, Kathleen J. Miglia, William S. Moore, Sushma Reddy, Frederick H. Sheldon, Christopher C. Witt, Tamaki Yuri
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Microinversions are cytologically undetectable inversions of DNA sequences that accumulate slowly in genomes. Like many other rare genomic changes (RGCs), microinversions are thought to be virtually homoplasy-free evolutionary characters, suggesting that they may be very useful for difficult phylogenetic problems such as the avian tree of life. However, few detailed surveys of these genomic rearrangements have been conducted, making it difficult to assess this hypothesis or understand the impact of microinversions upon genome evolution.
Results
We surveyed non-coding sequence data from a recent avian phylogenetic study and found substantially more microinversions than expected based upon prior information about …
Sexual Differentiation Of The Zebra Finch Song System: Potential Roles For Sex Chromosome Genes, Michelle L. Tomaszycki, Camilla Peabody, Kirstin Replogle, David F. Clayton, Robert J. Tempelman, Juli Wade
Sexual Differentiation Of The Zebra Finch Song System: Potential Roles For Sex Chromosome Genes, Michelle L. Tomaszycki, Camilla Peabody, Kirstin Replogle, David F. Clayton, Robert J. Tempelman, Juli Wade
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Recent evidence suggests that some sex differences in brain and behavior might result from direct genetic effects, and not solely the result of the organizational effects of steroid hormones. The present study examined the potential role for sex-biased gene expression during development of sexually dimorphic singing behavior and associated song nuclei in juvenile zebra finches.
Results
A microarray screen revealed more than 2400 putative genes (with a false discovery rate less than 0.05) exhibiting sex differences in the telencephalon of developing zebra finches. Increased expression in males was confirmed in 12 of 20 by qPCR using cDNA from …