Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Evolutionary Perspective Of Nicotine To Nornicotine Conversion, Its Regulation And Characterization Of Ein2 Mediated Ethylene Signaling In Tobacco, Manohar Chakrabarti
Evolutionary Perspective Of Nicotine To Nornicotine Conversion, Its Regulation And Characterization Of Ein2 Mediated Ethylene Signaling In Tobacco, Manohar Chakrabarti
University of Kentucky Doctoral Dissertations
Nicotine, nornicotine, anabasine and anatabine are four major alkaloids in tobacco, of which nicotine is predominant. In many tobacco cultivars and also in other Nicotiana species, nicotine is converted to nornicotine, which in turn gives rise to potent carcinogen NNN. Nicotine to nornicotine conversion via nicotine-N-demethylation is mediated by the CYP82E family of P450 enzymes. Tobacco (Nicotiana tabacum) converts in senescing leaves, while its diploid progenitors N.tomentosiformis and N.sylvestris convert in both green and senescing and only in senescing leaves, respectively. Previously it has been shown that N.tomentosiformis has different active conversion loci in green and senescing leaves. …