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Articles 1 - 13 of 13
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Phytochemical And Pharmacological Aspects Of Australian Bloodroots (Haemodora Spp.), Lei Liu, Myrna Deseo, D Thompson, Hans Wohlmuth, David Leach
Phytochemical And Pharmacological Aspects Of Australian Bloodroots (Haemodora Spp.), Lei Liu, Myrna Deseo, D Thompson, Hans Wohlmuth, David Leach
Dr Hans Wohlmuth
No abstract provided.
First Report Of Fingerprinting Dried Herbal Products Using A Subtractive Diversity Array, Linhai Niu, Nitin Mantri, Hans Wohlmuth, Chunguang Li, Charlie Xue, Edwin Pang
First Report Of Fingerprinting Dried Herbal Products Using A Subtractive Diversity Array, Linhai Niu, Nitin Mantri, Hans Wohlmuth, Chunguang Li, Charlie Xue, Edwin Pang
Dr Hans Wohlmuth
Introduction Sequence-independent microarrays have never been used to identify and authenticate dried herbal plants. Methods: We report successful fingerprinting of seven species: Leonurus sibiricus, Astragalus membranaceus, Coix lachryma-jobi, Magnolia biondii, Abutilon theophrasti, Physalis alkekengi, and Salvia miltiorrhiza from dried tissues using a sequence-independent microarray, “Subtracted Diversity Array”. Results: Herbal plants could be identified from tissues as they were sold at the clinic. Hierarchical cluster of these species generated using SPSS v.15.0 confirmed to their predicted taxonomical relationships as specified in the Angiosperm Phylogeny Group II classification system. A polymorphism rate of 40.7% was achieved from the 376 spots used for …
Parvifloranines A And B, Two 11-Carbon Alkaloids From Geijera Parviflora, Qingyao Shou, Linda Banbury, Joshua Smith, Xiaoxiang He, Ashley Dowell, Hans Griesser, Michael Heinrich, Hans Wohlmuth
Parvifloranines A And B, Two 11-Carbon Alkaloids From Geijera Parviflora, Qingyao Shou, Linda Banbury, Joshua Smith, Xiaoxiang He, Ashley Dowell, Hans Griesser, Michael Heinrich, Hans Wohlmuth
Dr Hans Wohlmuth
Two novel alkaloids (parvifloranines A and B), possessing an unusual 11-carbon skeleton linked with amino acids, were isolated from Geijera parviflora, an endemic Australian Rutaceae. Their structures were elucidated by extensive spectroscopic measurements including 2D NMR analyses. Parvifloranine A was found to be a mixture of two enantiomers, (S)-1 and (R)-1, in a ratio of 1:4, based on their separation using a chiral column. Parvifloranine B is also believed to be a mixture of enantiomers. Proposed biosynthetic pathways are discussed. Parvifloranine A inhibited the synthesis of nitric oxide in LPS-stimulated RAW 264.7 macrophages with an IC50 value of 23.4 μM.
A Gdna Microarray For Genotyping Salvia Species, Alexandra Olarte, Nitin Mantri, Gregory Nugent, Hans Wohlmuth, Chun Li, Charlie Xue, Edwin Pang
A Gdna Microarray For Genotyping Salvia Species, Alexandra Olarte, Nitin Mantri, Gregory Nugent, Hans Wohlmuth, Chun Li, Charlie Xue, Edwin Pang
Dr Hans Wohlmuth
Salvia is an important genus from the Lamiaceae with approximately 1,000 species. This genus is distributed globally and cultivated for ornamental, culinary, and medicinal uses. We report the construction of the first fingerprinting array for Salvia species enriched with polymorphic and divergent DNA sequences and demonstrate the potential of this array for fingerprinting several economically important members of this genus. In order to generate the Salvia subtracted diversity array (SDA) a suppression subtractive hybridization (SSH) was performed between a pool of Salvia species and a pool of angiosperms and non-angiosperms to selectively isolate Salvia-specific sequences. A total of 285-subtracted genomic …
Phenological Changes To The Chemical Composition And Biologicalactivity Of The Essential Oil From Moroccan Endemic Thyme (Thymusmaroccanus Ball), Chaima Jamali, Ayoub Kasrati, Khalid Bekkouche, Lahcen Hassani, Hans Wohlmuth, David Leach, Abdelaziz Abbad
Phenological Changes To The Chemical Composition And Biologicalactivity Of The Essential Oil From Moroccan Endemic Thyme (Thymusmaroccanus Ball), Chaima Jamali, Ayoub Kasrati, Khalid Bekkouche, Lahcen Hassani, Hans Wohlmuth, David Leach, Abdelaziz Abbad
Dr Hans Wohlmuth
The chemical composition, antioxidant and antimicrobial activities of essential oils isolated by hydrodistillation from the aerial parts of wild endemic Moroccan Thymus maroccanus at different developmental stages (vegetative, flowering and post-flowering) were evaluated. The yield of essential oils (v/w%) based on dry weight at different stages were: vegetative (2.14%), flowering (leaves: 1.80%; flowers: 3.46%), and post-flowering (leaves: 0.98%; post-flowers: 2.46%). Analysis of the essential oils by GC/MS revealed the presence of 28 components represented mainly by monoterpenes, both oxygenated (59.4–79.4%) and hydrocarbons (14.3–34.2%). The ranges of major constituents were as follow: carvacrol (14.1–77.6%), p-cymene (3.5–7.9%), γ-terpinene (3.8–6.6%) and α-pinene (1.2–7.8%). …
Chemical Composition, Antioxidant And Antimicrobial Activities Of Essential Oil Obtained From Wild And Cultivated Moroccan Thymus Species, Laila El Bouzidi, Chaima Jamali, Khalid Bekkouche, Lahcen Hassanil, Hans Wohlmuth, David Leach, Abdelaziz Abbad
Chemical Composition, Antioxidant And Antimicrobial Activities Of Essential Oil Obtained From Wild And Cultivated Moroccan Thymus Species, Laila El Bouzidi, Chaima Jamali, Khalid Bekkouche, Lahcen Hassanil, Hans Wohlmuth, David Leach, Abdelaziz Abbad
Dr Hans Wohlmuth
Thymus broussonetii, Thymus maroccanus and Thymus satureioides, are endemic Moroccan species that are intensively utilized because of their wide ranging medicinal and culinary properties. In an effort to preserve these over-exploited species, the effect of cultivation on the essential oil chemical composition, antioxidant and antimicrobial activities were investigated. The hydrodistilled oils obtained from wild and cultivated thyme species were analyzed by GC–MS. In total, 41 components were identified representing more than 98% of the oils, with carvacrol (26.0–71.6%), borneol (5.0–20.1%), γ-terpinene (4.0–8.9%) and p-cymene (5.2–10.3%) as the main constituents. Similar oil profiles were obtained from wild and cultivated T. maroccanus, …
Dioscorea Villosa (Wild Yam) Induces Chronic Kidney Injury Via Pro-Fibrotic Pathways, Ken Wojcikowski, Hans Wohlmuth, David Johnson, Glenda Gobe
Dioscorea Villosa (Wild Yam) Induces Chronic Kidney Injury Via Pro-Fibrotic Pathways, Ken Wojcikowski, Hans Wohlmuth, David Johnson, Glenda Gobe
Dr Hans Wohlmuth
Dioscorea villosa (wild yam) rhizome extract is a medicinal herb that is commonly used to treat symptoms of menopause and rheumatoid arthritis. We had evidence from previous in vitro experiments that this extract is toxic and pro-fibrotic in renal cells and aimed to test whether this occurs in vivo. Sprague-Dawley rats received 0.79 g/kg/d D. villosa extract in their food or no treatment over 7, 14 and 28d (n = 4 per group). Kidney and liver tissues were collected for protein extraction and Western immunoblots or fixed for special histologic stains, immunohistochemistry (IHC) and microscopy. Collagen deposition was assessed using …
A Simple Hplc Method For Detecting Adulteration Of Ginkgo Extracts With Flavonol Glycosides, Hans Wohlmuth, Kate Savage, Ashley Dowell, Peter Mouatt
A Simple Hplc Method For Detecting Adulteration Of Ginkgo Extracts With Flavonol Glycosides, Hans Wohlmuth, Kate Savage, Ashley Dowell, Peter Mouatt
Dr Hans Wohlmuth
No abstract provided.
Review Of Local And Traditional Plant Use By Australian Migrant Communities, Anna Du Chesne, Sue Evans, Adele Wessell, Hans Wohlmuth, Michael Heinrich
Review Of Local And Traditional Plant Use By Australian Migrant Communities, Anna Du Chesne, Sue Evans, Adele Wessell, Hans Wohlmuth, Michael Heinrich
Dr Hans Wohlmuth
No abstract provided.
Factors Affecting Pharmacists' Recommendations Of Cms: A Qualitative Pilot Study Of Australian Pharmacists, Sarah Culverhouse, Hans Wohlmuth
Factors Affecting Pharmacists' Recommendations Of Cms: A Qualitative Pilot Study Of Australian Pharmacists, Sarah Culverhouse, Hans Wohlmuth
Dr Hans Wohlmuth
No abstract provided.
A Review Of The Status Of Western Herbal Medicine In Australia, Hans Wohlmuth, Christopher Oliver, Pradeep Nathan
A Review Of The Status Of Western Herbal Medicine In Australia, Hans Wohlmuth, Christopher Oliver, Pradeep Nathan
Dr Hans Wohlmuth
Western herbal medicine is the most widely used form of herbal medicine in Australia although Ayurvedic and Chinese herbal medicines are becoming better known. The agricultural production and manufacture of locally grown herbs is, with some exceptions, relatively underdeveloped, as is the research and development of indigenous flora. However, the use of herbal medicine is increasingly becoming mainstream with retail sales of herbal products in Australia estimated to be A$200 million. Concurrent with the increase in popularity of herbal medicine with health consumers have come advances in herbal medicine education and regulation. Although small by European standards, research into herbal …
Essential Oil Composition And Antimicrobial Activity Of Wild And Cultivated Mint Timija (Mentha Suaveolens Subsp. Timija (Briq.) Harley), An Endemic And Threatened Medicinal Species In Morocco, A Kasrati, C Jamali, K Bekkouche, H Lahcen, M Markouk, Hans Wohlmuth, David Leach, A Abbad
Essential Oil Composition And Antimicrobial Activity Of Wild And Cultivated Mint Timija (Mentha Suaveolens Subsp. Timija (Briq.) Harley), An Endemic And Threatened Medicinal Species In Morocco, A Kasrati, C Jamali, K Bekkouche, H Lahcen, M Markouk, Hans Wohlmuth, David Leach, A Abbad
Dr Hans Wohlmuth
The hydro-distilled essential oils obtained from aerial parts of the wild (w) and cultivated (c) mint timija (Mentha suaveolens subsp. timija), an endemic medicinal species of Morocco, have been analyzed by GC–MS and screened for antimicrobial activity. In total, 35 compounds representing more than 98% of the oils were identified. Menthone (39.4(w)–10.8(c)%), pulegone (62.3(c)–34.3(w)%) and isomenthone (9.3(c)–7.8(w)%) were found as the main components for the two oils. The volatiles of the wild and cultivated material differed significantly in both the percentage of the main components and antimicrobial effect. Pulegone was more dominant in cultivated mint timija (62.3%) than in wild …
Pilidiostigmin, A Novel Bioactive Dimeric Acylphloroglucinol Derivative Isolated From Pilidiostigma Glabrum, Qingyao Shou, Hans Sun, Linda Banbury, Eleanore Lambley, Dane Renshaw, Christian Griesinger, Hans Griesser, Hans Wohlmuth
Pilidiostigmin, A Novel Bioactive Dimeric Acylphloroglucinol Derivative Isolated From Pilidiostigma Glabrum, Qingyao Shou, Hans Sun, Linda Banbury, Eleanore Lambley, Dane Renshaw, Christian Griesinger, Hans Griesser, Hans Wohlmuth
Dr Hans Wohlmuth
Pilidiostigmin, a novel dimeric acylphloroglucinol derivative, was isolated from the leaves of the Australian plant species Pilidiostigma glabrum (Myrtaceae). Pilidiostigmin exists in the plant in the form of a sodium salt, which is rare in natural products. The elucidation of the structure and relative configuration was achieved by spectroscopic measurements with special emphasis on 1D and 2D NMR techniques. Pilidiostigmin was found to display biological activity; it significantly and dose-dependently inhibited the synthesis of nitric oxide in LPS-stimulated RAW 264.7 macrophages at low micromolar concentrations.