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Fumonisins And Alternaria Alternata Lycopersici Toxins: Sphinganine Analog Mycotoxins Induce Apoptosis In Monkey Kidney Cells, Hong Wang, Clinton Jones, Janice Caiacci-Zanella, Todd Holt, David G. Gilchrist, Martin B. Dickman
Fumonisins And Alternaria Alternata Lycopersici Toxins: Sphinganine Analog Mycotoxins Induce Apoptosis In Monkey Kidney Cells, Hong Wang, Clinton Jones, Janice Caiacci-Zanella, Todd Holt, David G. Gilchrist, Martin B. Dickman
Department of Plant Pathology: Faculty Publications
Fusarium moniliforme toxins (fumonisins) and Alternaria alternata lycopersici (AAL) toxins are members of a new class of sphinganine analog mycotoxins that occur widely in the food chain. These mycotoxins represent a serious threat to human and animal health, inducing both cell death and neoplastic events in mammals. The mechanisms by which this family of chemical congeners induce changes in cell homeostasis were investigated in African green monkey kidney cells (CV-1) by assessing the appearance of apoptosis, cell cycle regulation, and putative components of signal transduction pathways involved in apoptosis. Structurally, these mycotoxins resemble the sphingoid bases, sphingosine and sphinganine, that …