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Different Chemically Substituted Chitooligosaccharides Inhibit Beta-Secretase Activity, Rosna Binti Mat Taha
Different Chemically Substituted Chitooligosaccharides Inhibit Beta-Secretase Activity, Rosna Binti Mat Taha
Rosna Binti Mat Taha
Chitooligosaccharide or COS is a kind of oligosaccharide that is an integral part of the nervous system. COS is synthesized by chemical substitution and derived AE-COS, DEAE-COS and DMAE-COS that are being shown on IC(50) value. AE-COS and DMAE-COS exhibited four fold less inhibition than DEAE-COS. In addition, non-competitive inhibitor was identified via a Dixon plot and the Ki inhibition constant (100 mu g/mL). We declared, chemical substitution of COS is a water soluble human safe BACE-1 inhibitor.
Antioxidant And Antibacterial Activities Of Ethanolic Extracts Of Asparagus Officinalis Cv. Mary Washington: Comparison Of In Vivo And In Vitro Grown Plant Bioactivities, Rosna Binti Mat Taha
Antioxidant And Antibacterial Activities Of Ethanolic Extracts Of Asparagus Officinalis Cv. Mary Washington: Comparison Of In Vivo And In Vitro Grown Plant Bioactivities, Rosna Binti Mat Taha
Rosna Binti Mat Taha
The antioxidant and antibacterial activities of ethanolic extracts of in vivo grown Asparagus officinalis cv. Mary Washington were investigated using superoxide dismutase, erythrocyte haemolysis and 2,2diphenyl-1-picrylhydrazil free radical scavenging methods. The measured antioxidant and antimicrobial potential were then compared to the activities offered by the ethanolic extracts of in vitro grown A. officinalis as well as ethanolic extract of undifferentiated callus cells of A. officinalis produced on Murashige and Skoog medium containing 1.5 mg/l 6-benzylaminopurine combined with 0.5 mg/l naphthalene acetic acid. The highest antioxidant capacity was obtained from the in vivo grown plant extract followed by in vitro grown …