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Regulation Of D-Galacturonate Metabolism In Caulobacter Crescentus By Humr, A Laci-Family Transcriptional Repressor, Craig Stephens, Aaesha I. Sheikh, Deborah Caswell, Cynthia Dick, Spencer Gang, Justin Jarrell, Ankita Kohli, Amanda Lieu, Jared Lumpe, Meghan Garrett, Jennifer Parker
Regulation Of D-Galacturonate Metabolism In Caulobacter Crescentus By Humr, A Laci-Family Transcriptional Repressor, Craig Stephens, Aaesha I. Sheikh, Deborah Caswell, Cynthia Dick, Spencer Gang, Justin Jarrell, Ankita Kohli, Amanda Lieu, Jared Lumpe, Meghan Garrett, Jennifer Parker
Biology
The oligotrophic freshwater bacterium Caulobacter crescentus encodes a cluster of genes (CC_1487 to CC_1495) shown here to be necessary for metabolism of D-galacturonate, the primary constituent of pectin, a major plant polymer. Sequence analysis suggests that these genes encode a version of the bacterial hexuronate isomerase pathway. A conserved 14 bp sequence motif is associated with promoter regions of three operons within this cluster, and is conserved in homologous gene clusters in related alpha-Proteobacteria. Embedded in the hexuronate gene cluster is a gene (CC_1489) encoding a member of the LacI family of bacterial transcription factors. This gene product, designated here …