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Characterization Of A Novel Negative Regulator Of Toxoflavin Production, Ntpr, In The Plant Pathogen Burkholderia Glumae That Causes Bacterial Panicle Blight Of Rice, Rebecca Ann Melanson
Characterization Of A Novel Negative Regulator Of Toxoflavin Production, Ntpr, In The Plant Pathogen Burkholderia Glumae That Causes Bacterial Panicle Blight Of Rice, Rebecca Ann Melanson
LSU Doctoral Dissertations
Burkholderia glumae is the major causal agent of bacterial panicle blight of rice, a disease that can cause significant yield losses. This bacterial pathogen produces a number of virulence factors that contribute to disease development. The phytotoxin, toxoflavin is required for full virulence and is the most important virulence factor in B. glumae. The known regulatory cascade of toxoflavin production involves the TofI-TofR quorum-sensing system, the transcriptional activators ToxJ and ToxR, and the toxoflavin biosynthesis and transport genes. Transposon mutagenesis of toxoflavin-producing B. glumae strains generated a number of mutants with increased toxoflavin production. Several of these mutants contained …