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Mutant P53 Regulation Of Cxc-Chemokine Expression In Head And Neck Squamous Cell Carcinoma, Brittany Field
Mutant P53 Regulation Of Cxc-Chemokine Expression In Head And Neck Squamous Cell Carcinoma, Brittany Field
Theses and Dissertations
Head and neck squamous cell carcinoma (HNSCC) is the 6th most common type of cancer in the western hemisphere with a five-year survival rate of only 50% for patients with a localized tumor, which decreases significantly to as low as 5% for those patients with tumors that have metastasized to distant sites of the body. It has been found that both mutant p53 and epidermal growth factor receptor (EGFR) signaling pathways function to increase the expression of CXCL5, which has been identified as a key mediator in the process of tumor metastasis. Previous data from our lab suggested that the …