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Divergent Roles Of Pi3k And Akt In Rapamycin-Induced Cardioprotection Against Ischemia-Reperfusion Injury, Shivani Kirit Desai
Divergent Roles Of Pi3k And Akt In Rapamycin-Induced Cardioprotection Against Ischemia-Reperfusion Injury, Shivani Kirit Desai
Theses and Dissertations
Coronary heart disease (CHD) is one of the leading causes of death every year with nearly three-fourths of all deaths caused by the disease. The challenge scientists are facing today is discovering new drugs to protect the heart against cellular damage caused by ischemia-reperfusion injury (I-R injury). Rapamycin is one such drug that has been shown to protect the heart against ischemia-induced cellular injury. Rapamycin(sirolimus) inhibits protein synthesis through inhibition of the mammalian target ofrapamycin (mTOR). This property of rapamycin has led to its current clinical applications in drug-eluting stents and in immunosuppresive treatment to organ transplant patients. The mechanism …