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Functional Characterization Of Mitogen-Dependent And Self-Perpetuating Nb2 Lymphoma Cell Lines, Charlotte Cockrell
Functional Characterization Of Mitogen-Dependent And Self-Perpetuating Nb2 Lymphoma Cell Lines, Charlotte Cockrell
Theses and Dissertations
This investigation involved the functional characterization of four Nb2 sub lines (Nb2-U- 17, Nb2-l l , SFJCD l , and D5) for their mitogenic and apoptotic responses to DEX ± PRL treatment. Many protein factors have been implicated to be crucial in controlling the apoptotic and mitogenic pathways. In conjunction with functional studies, an immunocytochemical investigation of four protein signals (NFKB, IKBa, STAT 5b, and the GR) was undertaken in an attempt to establish a relationship between the functional responsiveness of a given cell line and the concentration of a particular protein marker. Comparison of the functional data obtained for …