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Physiology

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Virginia Commonwealth University

Theses and Dissertations

1987

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Effects Of Hematocrit Variations On Microcirculatory Hemodynamics And Oxygen Transport In Hamster Striated Muscle, Lih Kuo Jan 1987

Effects Of Hematocrit Variations On Microcirculatory Hemodynamics And Oxygen Transport In Hamster Striated Muscle, Lih Kuo

Theses and Dissertations

Experiments were performed to investigate the influence of isovolemic hemodilution and hemoconcentration on microcirculatory hemodynamics and oxygen transport in the hamster cheek pouch retractor muscle. Measurements of red blood cell velocity, microvessel hematocrit, vessel diameter, segment length (L), hemoglobin oxygen saturation (SO2) and longitudinal SO2 gradient (ΔSO2/L) were made in four arteriolar branching orders before and after isovolemic exchange with plasma (hemodilution) or packed red blood cells (hemoconcentration).

In the study of hemodilution, systemic hematocrit was reduced from 52 to 33% in 23 hamsters. This degree of hemodilution resulted in an average decrease in microcirculatory …