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Deterministic Model Of The Voltage Dependent Anion Channel (Vdac) Kinetics, Viren Shah
Deterministic Model Of The Voltage Dependent Anion Channel (Vdac) Kinetics, Viren Shah
Theses and Dissertations
The voltage-dependent anion channel (VDAC) is a voltage gated channel residing on the outer mitochondrial membrane (OMM) that facilitates the flow of metabolites between the cytosol and mitochondria. The channel is regulated through conformational changes driven by electrostatic effects along with numerous regulatory mechanisms. The aim of this study is to mechanistically model kinetics of substrate flow through VDAC and incorporate them into existing mechanistic computational models of mitochondrial function. The resulting model is used in two ways: 1) to establish mitochondrial bioenergetics (conductance, permeability, and current/flux) under physiological conditions, and 2) to conduct perturbations simulating the effect of altered …
Quantitative Optical Imaging Of Metabolic And Structural Biomarkers In Rodent Injury Models, Shima Mehrvar
Quantitative Optical Imaging Of Metabolic And Structural Biomarkers In Rodent Injury Models, Shima Mehrvar
Theses and Dissertations
The assessment of organ metabolic function using optical imaging techniques is an overgrowing field of disease diagnosis. The broad research objective of my PhD thesis is to detect quantitative biomarkers by developing and applying optical imaging and image processing tools to animal models of human diseases. To achieve this goal, I have designed and implemented an optical imaging instrument called in vivo fluorescence imager to study wound healing progress. I have also developed a 3-dimensional (3D) vascular segmentation technique that uses intrinsic fluorescence images of whole organs.
Intrinsic fluorophores (autofluorescence signals) provide information about the status of cellular bioenergetics in …