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The Interaction Between A Thiol Specific Probe (Opa) And The Single Channel Characteristics Of The Reconstituted Ca++ Release Protein From Skeletal Muscle Sarcoplasmic Reticulum, Alexander Braun
Dissertations and Theses
One advantage of higher life-forms over less developed organisms is their ability to respond to signals from their environment with motion. This requires highly specialized contractile cells and a whole locomotion apparatus. In vertebrates, the cells responsible for movement are the skeletal muscle cells. They receive signals from the autonomic nervous system in the form of an action potential, and they contract in an appropriate manner. Calcium is a vital intracellular passenger whose role in muscular function is to initiate contraction. It is released via specific channel proteins from an internal Ca++ store, the sarcoplasmic reticulum, and triggers muscular contraction, …
O-Phthalaldehyde Modification Of Sarcoplasmic Reticulum Calcium Release, Steffen Koehler
O-Phthalaldehyde Modification Of Sarcoplasmic Reticulum Calcium Release, Steffen Koehler
Dissertations and Theses
Muscle contraction is a phenomena which fascinated already the ancient Greeks. People have long sought to understand the mechanism of muscle contraction. Today we know that in order for muscle to contract, an action potential propagates from the nerve cell to the muscle cell. Upon arriving at the muscle cell, via a mechanism called Excitation- Contraction (E-C) coupling, Ca2 + is released from an intracellular membrane system, the sarcoplasmic reticulum (SR), into the intracellular fluid. The increase of intracellular Ca2 + initiates the interaction between the contractile units which results in force development and tension. The least well understood step …