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Regulation Of Cytoplasmic Dynein By Lis1 And Adenomatous Polyposis Coli, Timothy Joshua Hines
Regulation Of Cytoplasmic Dynein By Lis1 And Adenomatous Polyposis Coli, Timothy Joshua Hines
Theses and Dissertations
Cytoplasmic dynein 1 (dynein) is a microtubule motor that plays a role in mitosis, cell migration, and minus-end directed microtubule-based transport. The lissencephaly protein, Lis1, and its binding partner, Ndel1, are critical regulators of cytoplasmic dynein (Niethammer et al., 2000). In humans, haploinsufficiency of Lis1 leads to lissencephaly, a devastating developmental neurological disorder characterized by severe brain malformation, leading to cognitive and motor defects, and progressively worsening seizures (Dobyns et al., 1993). While Lis1 is known to play a role in regulating dynein-dependent functions such as neuronal migration and mitotic spindle orientation during development, the protein is still highly expressed …