Open Access. Powered by Scholars. Published by Universities.®
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Entire DC Network
Extracellular Vimentin Is Sufficient To Promote Cell Attachment, Spreading, And Motility By A Mechanism Involving N-Acetyl Glucosamine-Containing Structures, Robert Bucki, Daniel V. Iwamoto, Xuechen Shi, Katherine E. Kerr, Fitzroy J. Byfield, Lukasz Suprewicz, Karol Sklodowski, Julian Sutaria, Pawel Misiak, Agnieszka Z. Wilczewska, Sekar Ramachandran, Aaron Wolfe, Minh H. Thanh, Eli Whalen, Alison E. Patteson, Paul A. Janmey
Extracellular Vimentin Is Sufficient To Promote Cell Attachment, Spreading, And Motility By A Mechanism Involving N-Acetyl Glucosamine-Containing Structures, Robert Bucki, Daniel V. Iwamoto, Xuechen Shi, Katherine E. Kerr, Fitzroy J. Byfield, Lukasz Suprewicz, Karol Sklodowski, Julian Sutaria, Pawel Misiak, Agnieszka Z. Wilczewska, Sekar Ramachandran, Aaron Wolfe, Minh H. Thanh, Eli Whalen, Alison E. Patteson, Paul A. Janmey
Physics - All Scholarship
Vimentin intermediate !laments form part of the cytoskeleton
of mesenchymal cells, but under pathological conditions often
associatedwith in"ammation, vimentin !laments depolymerize as
the result of phosphorylation or citrullination, and vimentin
oligomers are secreted or released into the extracellular environment.
In the extracellular space, vimentin can bind surfaces of cells
and the extracellular matrix, and the interaction between extracellular
vimentin and cells can trigger changes in cellular functions,
such as activation of !broblasts to a !brotic phenotype. The
mechanism by which extracellular vimentin binds external cell
membranes and whether vimentin alone can act as an adhesive
anchor for cells is largely …
Vimentin Tunes Cell Migration On Collagen By Controlling Β1 Integrin Activation And Clustering, Zofia Ostrowska-Podhorodecka, Isabel Ding, Wilson Lee, Jelena Tanic, Sevil Abbasi, Pamma D. Arora, Richard S. Liu, Alison E. Patteson, Paul A. Janmey, Christopher A. Mcculloch
Vimentin Tunes Cell Migration On Collagen By Controlling Β1 Integrin Activation And Clustering, Zofia Ostrowska-Podhorodecka, Isabel Ding, Wilson Lee, Jelena Tanic, Sevil Abbasi, Pamma D. Arora, Richard S. Liu, Alison E. Patteson, Paul A. Janmey, Christopher A. Mcculloch
Physics - All Scholarship
Vimentin is a structural protein that is required for mesenchymal cell migration and directly interacts with actin, β1 integrin and paxillin. We examined how these interactions enable vimentin to regulate cell migration on collagen. In fibroblasts, depletion of vimentin increased talin-dependent activation of β1 integrin by more than 2-fold. Loss of vimentin was associated with reduction of β1 integrin clustering by 50% and inhibition of paxillin recruitment to focal adhesions by more than 60%, which was restored by vimentin expression. This reduction of paxillin was associated with 65% lower Cdc42 activation, a 60% reduction of cell extension formation and a …
Rigidity And Fluidity In Living And Nonliving Matter, Jorge Hernan Lopez
Rigidity And Fluidity In Living And Nonliving Matter, Jorge Hernan Lopez
Dissertations - ALL
Many of the standard equilibrium statistical mechanics techniques do not readily apply to non-equilibrium phase transitions such as the fluid-to-disordered solid transition found in repulsive particulate systems. Examples of repulsive particulate systems are sand grains and colloids. The first part of this thesis contributes to methods beyond equilibrium statistical mechanics to ultimately understand the nature of the fluid-to-disordered solid transition, or jamming, from a microscopic basis.
In Chapter 2 we revisit the concept of minimal rigidity as applied to frictionless, repulsive soft sphere packings in two dimensions with the
introduction of the jamming graph. Minimal rigidity is a purely combinatorial …