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Understanding The Role Of Electrostatics On Protein-Protein Binding, Rooplekha C Mitra
Understanding The Role Of Electrostatics On Protein-Protein Binding, Rooplekha C Mitra
All Theses
Ionized groups carry net charge and thus play a major role in the electrostatic interactions between the ligand and receptor. So understanding the role of electrostatics on protein-protein interactions is crucial for understanding the contribution of ionizable groups to the binding. However, their ionization states depend on many factors including pH of water phase. The complexity comes from the fact that the pKa's of ionizable groups may be quite different from their standard values and even may change due to protein-protein binding. The main difficulty in modeling plausible ionization changes induced by the complex formation arises from the differences in …
Understanding The Biological And Environmental Implications Of Nanomaterials, Sijie Lin
Understanding The Biological And Environmental Implications Of Nanomaterials, Sijie Lin
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The last two decades have witnessed the discovery, development, and large-scale manufacturing of novel nanomaterials. While nanomaterials bring in exciting and extraordinary properties in all areas of materials, electronics, mechanics, and medicine, they also could generate potential adverse effects in biological systems and in the environment. The currently limited application of nanomaterials in biological and ecological systems results from the insufficient and often controversial data on describing the complex behaviors of nanomaterials in living systems. The purpose of this dissertation intends to fill such a knowledge void with methodologies from the disciplines of biophysics, biology, and materials science and engineering. …
A Solution-Based Approach To The Fabrication Of Novel Chalcogenide Glass Materials And Structures, Nathan Carlie
A Solution-Based Approach To The Fabrication Of Novel Chalcogenide Glass Materials And Structures, Nathan Carlie
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Chalcogenide glasses (ChGs) are well known for their large optical nonlinearities and high infrared transparency, and are candidate materials for next-generation thin film-based planar infrared (IR) optical applications. They are also known, however, to possess low thermal and mechanical stability as compared to oxide glasses. Traditional physical vapor deposition (PVD) methods used for the deposition of these materials as thin films often suffer from low deposition rates, deviation from stoichiometry, and cannot coat over complex surfaces. In order to retain the attractive optical properties of ChGs while enabling new fabrication routes and hybrid and composite material systems, we have developed …