Digital Commons Network^™

Analyzing The Production And Use Of Fossil Fuels: A Case For Data Mining And Gis, Alejandro Conde

Geography and the Environment: Graduate Student Capstones

As technology progresses and data grows both larger and more complex, techniques are being developed to keep up with the exponential growth of information. The term “data mining” is a blanket term used to describe an approach to find anomalies and correlations in a large dataset. This approach involves leveraging data mining software to manipulate and prepare data, apply statistics to quantify trends and characteristics in the data from a high level, and potentially apply advanced techniques like machine learning to identify patterns that wouldn’t be apparent otherwise. In this case study, data mining aided a GIS in displaying substantial …

Point Of Use Technologies To Increase Access To Clean Water In Rural Communities, Elena Arroway

Undergraduate Theses, Capstones, and Recitals

Access to clean water is an issue that many communities around the world struggle with. While large-scale efforts such as piping infrastructure have been successful, these are less effective at reaching small, rural communities. To supplement these efforts, point of use (POU) methods for water treatment can be implemented. These include boiling, chemical treatment, filters, and several additional technologies. These have all shown effectiveness in a lab setting, but their implementation in the real world, specifically in rural communities, has not been nearly as effective. In this paper, several different POU methods are evaluated for their effectiveness on a small-scale, …

Lipophilic Probes For Cellular Ethylene Detection, Morgan R. Brown

Electronic Theses and Dissertations

The structure of ethylene is simple, yet its biological effects are significant. When considering its role in biology it is almost exclusively regarded as a plant hormone. Research on ethylene from plants was progressed by several advancements in analytical instrumentation, from its discovery to elucidation of its signaling pathway. There is currently limited understanding of ethylene’s role in mammals, but evidence suggests that it may be a biomarker for oxidative stress! Additional tools and technology are crucial to study this surprising and important signaling role in mammals. Our group has developed molecular ethylene probes as a strategy to detect ethylene …

On Loop Commutators, Quaternionic Automorphic Loops, And Related Topics, Mariah Kathleen Barnes

Electronic Theses and Dissertations

This dissertation deals with three topics inside loop and quasigroup theory. First, as a continuation of the project started by David Stanovský and Petr Vojtĕchovský, we study the commutator of congruences defined by Freese and McKenzie in order to create a more pleasing, equivalent definition of the commutator inside of loops. Moreover, we show that the commutator can be characterized by the generators of the inner mapping group of the loop. We then translate these results to characterize the commutator of two normal subloops of any loop.

Second, we study automorphic loops with the desire to find more examples of …

Bicycles And Transit: Weather Or Not: A Study On The Effect Of Weather And Air Quality On Bicycle-Transit, Bicycle, Rail Transit Counts In Denver, Christiana M. Fairfield

Electronic Theses and Dissertations

The movement of people and goods within metropolitan areas is critically important to the operational efficiency and functionality of cities. This study explores the influence of local weather conditions and the air quality index on bicycle-transit user in Denver, Colorado. Based on bicycle-transit having two key components, bicycle and transit, the effect of local weather conditions and the air quality index is also explored with bicycle use and rail-transit usage. Key findings include: (1) the most significant variable across all three modes is temperature, (2) for bicycle-transit and bicycle use, there is a steady increase in ridership as temperatures increase …

Esipt-Enabled Alkyne Migration Provides Rapid Access To Benzoxazinones, Andrés G. Muñoz

Electronic Theses and Dissertations

Benozoxazinones have long been of interest to agrochemical scientists and medicinal chemists because of their widespread biological activity. These scaffolds are also of interest to synthetic chemists, who recognize the utility of benzoxazinones for accessing functionalized heterocycles. The use of efavirenz, a benzoxazinone-based reverse transcriptase inhibitor used in the treatment of HIV-1, has brought increased attention to this privileged pharmacophore. While there exist numerous strategies for synthesizing benzoxazinones, methods that do not require the use of acutely toxic and environmentally hazardous reagents are lacking. Consequently, there is a need to develop new methods for constructing this valuable scaffold. Herein, we …

Dynamics And Turnover Of Lipid And Protein Domains In Cells And Supported Bilayers, Alan Weisgerber

Electronic Theses and Dissertations

Protein and lipid clustering is an important mechanism for cell processes such as exo- and endo-cytosis and creating functional signaling complexes. It has been seen that both lipids and proteins are involved with the formation of cluster domains on cell membranes, yet little is known about the interplay between the two. In this work I began with visualizing lipid sorting to artificially induced curvature in supported lipid bilayers, with lipid tails affecting the sorting differently to curvature. These results demonstrate that lipids sort to curvature on curved, supported lipid bilayers. The sorting depends on the number of lipids in the …

Directly Polymerizable Co Releasing Molecules, Jackson Snow

Electronic Theses and Dissertations

Despite the commonly held consensus that carbon monoxide (CO) is toxic, it has been shown to be an essential signaling molecule in the human neuronal system and has been noted to have anti-inflammatory properties, act as a vasodilator, have anti-proliferative impacts on tumors, and many other beneficial effects. The current limitation to using CO as a therapeutic molecule is delivering the proper dosages using CO releasing molecules (CORMs) without exhibiting toxicity. The first chapter of this thesis will review the biological significance of CO in biological systems, the limitations of existing CORMs, and the properties of diphenylcyclopropenone (DPCP) that make …

Soil Resilience And Arbuscular Mycorrhizal Fungi: How Fungi Can Inform Climate Change Mitigation And Adaptation In Maya Milpa Management, Courtney Mathers

Electronic Theses and Dissertations

In Mexico’s state of Yucatán, climate change impacts like prolonged and less predictable dry season length are manifesting as threats to agricultural production and food security. Nearly two thirds of Yucatán’s population is indigenous, many of whom live in rural communities that rely on rainfed subsistence agriculture (INEGI 2015). Ensuring sufficient food production in the face of climate change relies on the quality of agricultural soils. With both mismanagement of agricultural soils and climate change posing as threats to food production in Mexico, soil management practices that increase a soil quality should be identified and promoted. The primary objective of …

Investigating Spatiotemporal Kinetics, Dynamics, And Mechanism Of Exosome Release, Anarkali Mahmood

Electronic Theses and Dissertations

Exosomes are small lipid-based vesicles that can carry biomolecules from one cell to another. While exosomes are crucial to maintain homeostasis in healthy cells, they are exploited by unhealthy cells to aid disease progression. Exosomes likely facilitate disease progression via the transfer of disease-causing biomolecules from unhealthy to healthy cells. Exosomes are generated in Multivesicular endosomes (MVEs) and are then secreted into the extracellular space to travel to other cells. Despite being a crucial step, very little is known about exosomes release mechanism and dynamics. To further our understanding of exosomes, specifically their secretion, my work has focused on investigating …

Electron Spin Relaxation Of Nitroxide Spin Labels And Relaxation Processes, Thacien Ngendahimana

Electronic Theses and Dissertations

MTSL is the nitroxide spin label that is most commonly used in site-directed spin labeling. However, due to rotation of its gem-dimethyl groups that average anisotropic interactions, T_m becomes short above about 70 K and this makes DEER experiments difficult at these temperatures. Strategies for decreasing spin echo dephasing and electron spin lattice relaxation rates are important for design of nitroxide spin labels and molecular qubits.

In searching for labels with longer T_m, new nitroxide spin labels devoid of gemdimethyl groups or with more rigid structures were synthesized at the University of Nebraska and pulsed EPR measurements …

Measurements Of Atmospheric Radicals, Heather L. Runberg

Electronic Theses and Dissertations

Atmospheric particulate matter (PM) is a global health concern. PM_2.5 is formed primarily through combustion processes such as automobile use and industrial activity. Natural sources of PM_2.5 result from events like volcanos and wildfires. Upon inhalation, PM_2.5 is small enough to travel deep into the lungs where it can form reactive oxygen species (ROS), such as hydroxyl radical (OH), causing oxidative damage to pulmonary tissues. PM_2.5 has been linked to cardiopulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), and high blood pressure.

PM_2.5 is small enough to remain aloft and travel many hundreds …

Local-Global Results On Discrete Structures, Alexander Lewis Stevens

Electronic Theses and Dissertations

Local-global arguments, or those which glean global insights from local information, are central ideas in many areas of mathematics and computer science. For instance, in computer science a greedy algorithm makes locally optimal choices that are guaranteed to be consistent with a globally optimal solution. On the mathematical end, global information on Riemannian manifolds is often implied by (local) curvature lower bounds. Discrete notions of graph curvature have recently emerged, allowing ideas pioneered in Riemannian geometry to be extended to the discrete setting. Bakry- Émery curvature has been one such successful notion of curvature. In this thesis we use combinatorial …

Inhibitors Of Alpha-Synuclein Aggregation, Jemil Ahmed

Electronic Theses and Dissertations

Alpha-Synuclein (αS) – a neuronal, disordered, presynaptic protein – aggregates into amyloid fibrils and accumulates in the substantia nigra pars compacta of Parkinson's Disease (PD) patients. The aggregation and accumulation of αS amyloid fibrils leads to death of dopaminergic neurons; a hallmark of PD. Although it’s not clear why αS aggregates, prior studies have found that intrastriatal injection of fibril alone is sufficient to cause PD pathology in mouse and non-human primates models. These observations implicate αS as a therapeutic target against PD.

Unfortunately, there are three caveats when attempting to target αS. First, αS is a neuronal protein expressed …

Topics In Moufang Loops, Riley Britten

Electronic Theses and Dissertations

We will begin by discussing power graphs of Moufang loops. We are able to show that as in groups the directed power graph of a Moufang loop is uniquely determined by the undirected power graph. In the process of proving this result we define the generalized octonion loops, a variety of Moufang loops which behave analogously to the generalized quaternion groups. We proceed to investigate para-F quasigroups, a variety of quasigroups which we show are antilinear over Moufang loops. We briefly depart from the context of Moufang loops to discuss solvability in general loops. We then prove some results on …

Banach Spaces On Topological Ramsey Structures, Cheng-Chih Ko

Electronic Theses and Dissertations

A Banach space T₁(d, θ) with a Tsirelson-type norm is constructed on the top of the topological Ramsey space T₁ defined by Dobrinen and Todorcevic [6]. Finite approximations of the isomorphic subtrees are utilised in constructing the norm. The subspace on each “branch” of the tree is shown to resemble the structure of an ℓ_∞ⁿ⁺¹ -space where the dimension corresponds to the number of terminal nodes on that branch. The Banach space T₁(d, θ) is isomorphic to (∑_n∊ℕ⊕ℓ_∞ⁿ⁺¹)_p , where d ∈ ℕ with d ≥ 2, …

Pathways Forward For Onshore Wind Energy In The State Of Maryland: A Gis Multi-Criteria Analysis, George Pisano

Geography and the Environment: Graduate Student Capstones

This study examines pathways forward for onshore wind energy in the State of Maryland. To meet its decarbonization goals, Maryland needs to quickly transition its electric grid away from fossil fuels. The state is currently in the process of developing offshore wind farms that have the potential to represent a significant source of renewable energy. However little progress has been made in expanding Maryland’s onshore wind energy production capacity. Using a multi-criteria GIS analysis, this study found that there is a limited but not inconsiderable area in the state that could be suitable for wind farms of varying scales that …