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Exponentiated Kumaraswamy-Dagum Distribution With Applications To Income And Lifetime Data, Shujiao Huang, Broderick O. Oluyede

Department of Mathematical Sciences Faculty Publications

A new family of distributions called exponentiated Kumaraswamy-Dagum (EKD) distribution is proposed and studied. This family includes several well known sub-models, such as Dagum (D), Burr III (BIII), Fisk or Log-logistic (F or LLog), and new sub-models, namely, Kumaraswamy-Dagum (KD), Kumaraswamy-Burr III (KBIII), Kumaraswamy-Fisk or Kumaraswamy-Log-logistic (KF or KLLog), exponentiated Kumaraswamy-Burr III (EKBIII), and exponentiated Kumaraswamy-Fisk or exponentiated Kumaraswamy-Log-logistic (EKF or EKLLog) distributions. Statistical properties including series representation of the probability density function, hazard and reverse hazard functions, moments, mean and median deviations, reliability, Bonferroni and Lorenz curves, as well as entropy measures for this class of distributions and the …

Nicotine Exploits A Copi-Mediated Process For Chaperone-Mediated Up-Regulation Of Its Receptors, Brandon J. Henderson, Rahul Srinivasan, Weston A. Nichols, Crystal N. Dilworth, Diana F. Gutierrez, Elisha D. W. Mackey, Sheri Mckinney, Ryan M. Drenan, Christopher I. Richards, Henry A. Lester

Chemistry Faculty Publications

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this …

Frameworks With Crystallographic Symmetry, Ciprian Borcea, Ileana Streinu

Computer Science: Faculty Publications

Periodic frameworks with crystallographic symmetry are investigated from the perspective of a general deformation theory of periodic bar-and-joint structures in R^d. It is shown that natural parametrizations provide affine section descriptions for families of frameworks with a specified graph and symmetry. A simple geometric setting for diaplacive phase transitions is obtained. Upper bounds are derived for the number of realizations of minimally rigid periodic graphs.

Amino Acid Region 1000–1008 Of Factor V Is A Dynamic Regulator For The Emergence Of Procoagulant Activity, Joesph R. Wiencek, Mahesheema Na, Jamila Hirbawi, Michael Kalafatis

Chemistry Faculty Publications

Single chain factor V (fV) circulates as an Mr 330,000 quiescent pro-cofactor. Removal of the B domain and generation of factor Va (fVa) are vital for procoagulant activity. We investigated the role of the basic amino acid region 1000-1008 within the B domain of fV by constructing a recombinant mutant fV molecule with all activation cleavage sites (Arg(709)/Arg(1018)/Arg(1545)) mutated to glutamine (fV(Q3)), a mutant fV molecule with region 1000-1008 deleted (fV(ΔB9)), and a mutant fV molecule containing the same deletion with activation cleavage sites changed to glutamine (fV(ΔB9/Q3)). The recombinant molecules along with wild type fV (fV(WT)) were transiently expressed …

Primary Care-Based Educational Interventions To Decrease Risk Factors For Metabolic Syndrome For Adults With Major Psychotic And/Or Affective Disorders: A Systematic Review, Cynthia Nover, Sarah S. Jackson

Epidemiology Faculty Publications

Background

Individuals with major psychotic and/or affective disorders are at increased risk for developing metabolic syndrome due to lifestyle- and treatment-related factors. Numerous pharmacological and non-pharmacological interventions have been tested in inpatient and outpatient mental health settings to decrease these risk factors. This review focuses on primary care-based non-pharmacological (educational or behavioral) interventions to decrease metabolic syndrome risk factors in adults with major psychotic and/or affective disorders.

Methods

The authors conducted database searches of PsychINFO, MEDLINE and the Cochrane Database of Systematic Reviews, as well as manual searches and gray literature searches to identify included studies.

Results

The authors were …

Efficient And Long-Time Accurate Second-Order Methods For The Stokes-Darcy System, Wenbin Chen, Max Gunzburger, Dong Sun, Xiaoming Wan

Mathematics and Statistics Faculty Research & Creative Works

We propose and study two second order in time implicit-explicit methods for the coupled Stokes-Darcy system that governs flows in karst aquifers and other subsurface flow systems. the first method is a combination of a second-order backward differentiation formula and the second order Gear's extrapolation approach. the second is a combination of the second-order Adams-Moulton and second-order Adams-Bashforth methods. Both algorithms only require the solution of decoupled Stokes and Darcy problems at each time-step. Hence, these schemes are very efficient and can be easily implemented using legacy codes. We establish the unconditional and uniform in time stability for both schemes. …

Understanding Human Learning Using A Multiagent Based Unified Learning Model Simulation, Vlad T. Chiriacescu

Department of Computer Science and Engineering: Dissertations, Theses, and Student Research

Within cognitive science, computational modeling based on cognitive architectures has been an important approach to addressing questions of human cognition and learning. Modeling issues such as limited expressivity in representing knowledge and lack of appropriate selection of model structure represent a challenge for existing architectures. Furthermore, latest research shows that the concepts of long-term memory, motivation and working memory are critical cognitive aspects but a unifying cognitive paradigm integrating those concepts hasn’t been previously achieved.

Derived from a synthesis of neuroscience, cognitive science, psychology, and education, the Unified Learning Model (ULM) provides this integration by merging a statistical learning mechanism …

Multi-State Models For Natural History Of Disease, Amy Laird, Rebecca A. Hubbard, Lurdes Y. T. Inoue

UW Biostatistics Working Paper Series

Longitudinal studies are a useful tool for investigating the course of chronic diseases. Many chronic diseases can be characterized by a set of health states. We can improve our understanding of the natural history of the disease by modeling the sequence of visited health states and the duration in each state. However, in most applications, subjects are observed only intermittently. This observation scheme creates a major modeling challenge: the transition times are not known exactly, and in some cases the path through the health states is not known.

In this manuscript we review existing approaches for modeling multi-state longitudinal data. …

Students' Perceived Utility Of Precision Taught Calculus, Rebecca-Anne Dibbs, David Glassmeyer, Wafa Yacoub

Faculty Articles

The last decade of calculus research has showed students learn best when lecture is supplemented with thoughtful use of technology and group work; however, educators are given little direction of how they are to balance the already full first semester calculus class. Precision teaching is an instructional model that employs formative assessment to provide information on what topics are understood by students as well as indicate troublesome concepts. With this information, the instructor can adjust class time accordingly by incorporating supplemental activities most beneficial to students. The purpose of this interview study was to explore the perceived utility of precision …

A Search For Enhanced Very High Energy Gamma-Ray Emission From The 2013 March Crab Nebula Flare, P. T. Reynolds, Et Al

Physical Sciences Publications

In 2013 March, a flaring episode from the Crab Nebula lasting ~2 weeks was detected by Fermi-LAT (Large Area Telescope on board the Fermi Gamma-ray Space Telescope). The Very Energetic Radiation Imaging Telescope Array System (VERITAS) provides simultaneous observations throughout this period. During the flare, Fermi-LAT detected a 20 fold increase in flux above the average synchrotron flux >100 MeV seen from the Crab Nebula. Simultaneous measurements with VERITAS are consistent with the non-variable long-term average Crab Nebula flux at TeV energies. Assuming a linear correlation between the very high energy flux change >1 TeV and the flux …

Long Term Observations Of B2 1215+30 With Veritas, E. Aliu, S. Archambault, T. Arlen, T. Aune, M. Beilicke, W. Benbow, R. Bird, A. Bouvier, J. H. Buckley, V. Bugaev, A. Cesarini, L. Ciupik, M. P. Connolly, W. Cui, J. Dumm, M. Errando, A. Falcone, S. Federici, Q. Feng, J. P. Finley, P. Fortin, L. Fortson, A. Furniss, N. Galante, L. Gerard, G. H. Gillanders, S. Griffin, J. Grube, G. Gyuk, D. Hanna, J. Holder, G. Hughes, T. B. Humensky, P. Kaaret, M. Kertzman, Y. Khassen, D. Kieda, H. Krawczynski, F. Krennrich, M. J. Lang, A. S. Madhavan, G. Maier, P. Majumdar, S. Mcarthur, A. Mccann, P. Moriarty, R. Mukherjee, D. Nieto, A. O’Faolain De Bhroithe, P. T. Reynolds, Et Al

Physical Sciences Publications

We report on VERITAS observations of the BL Lac object B2 1215+30 between 2008 and 2012. During this period, the source was detected at very high energies (VHEs; E > 100 GeV) by VERITAS with a significance of 8.9σ and showed clear variability on timescales larger than months. In 2011, the source was found to be in a relatively bright state and a power-law fit to the differential photon spectrum yields a spectral index of 3.6 ± 0.4stat ± 0.3syst with an integral flux above 200 GeV of (8.0 ± 0.9stat ± 3.2syst) × 10−12 cm−2 s−1. No short term variability …

Molecular Hydrogen Regulated Star Formation In Cosmological Smoothed Particle Hydrodynamics Simulations, Robert Thompson, Kentaro Nagamine, Jason Jaacks, Jun-Hwan Choi

Physics and Astronomy Faculty Publications

Some observations have shown that star formation (SF) correlates tightly with the presence of molecular hydrogen (H₂); therefore, it is important to investigate its implication on galaxy formation in a cosmological context. In the present work, we implement a sub-grid model (hereafter H₂-SF model) that tracks the H₂ mass fraction within our cosmological smoothed particle hydrodynamics code GADGET-3 by using an equilibrium analytic model of Krumholz et al. This model allows us to regulate the SF in our simulation by the local abundance of H₂ rather than the total cold gas density, which naturally …

Data Management In Cloud Environments: Nosql And Newsql Data Stores, Katarina Grolinger, Wilson A. Higashino, Abhinav Tiwari, Miriam Am Capretz

Electrical and Computer Engineering Publications

: Advances in Web technology and the proliferation of mobile devices and sensors connected to the Internet have resulted in immense processing and storage requirements. Cloud computing has emerged as a paradigm that promises to meet these requirements. This work focuses on the storage aspect of cloud computing, specifically on data management in cloud environments. Traditional relational databases were designed in a different hardware and software era and are facing challenges in meeting the performance and scale requirements of Big Data. NoSQL and NewSQL data stores present themselves as alternatives that can handle huge volume of data. Because of the …

Automated Annotation Of Functional Imaging Experiments Via Multi-Label Classification, Matthew D. Turner, Chayan Chakrabarti, Thomas B. Jones, Jiawei F. Xu, Peter T. Fox, George F. Luger, Angela Laird, Jessica A. Turner

Department of Physics

Identifying the experimental methods in human neuroimaging papers is important for grouping meaningfully similar experiments for meta-analyses. Currently, this can only be done by human readers. We present the performance of common machine learning (text mining) methods applied to the problem of automatically classifying or labeling this literature. Labeling terms are from the Cognitive Paradigm Ontology (CogPO), the text corpora are abstracts of published functional neuroimaging papers, and the methods use the performance of a human expert as training data. We aim to replicate the expert's annotation of multiple labels per abstract identifying the experimental stimuli, cognitive paradigms, response types, …

Weak Interaction Studies Ith 6He, A. Knecht, Z. T. Alexander, Y. Bagdasarova, T. M. Cope, B. G. Delbridge, X. Fléchard, A. García, R. Hong, E. Liénard, P. Mueller, O. Naviliat-Cuncic, A. S.C. Palmer, R. G.H. Robertson, D. W. Storm, H. E. Swanson, S. Utsuno, F. Wauters, William Williams, C. Wrede, D. W. Zumwalt

Physics: Faculty Publications

The 6He nucleus is an ideal candidate to study the weak interaction. To this end we have built a high-intensity source of 6He delivering ∼1010 atoms/s to experiments. Taking full advantage of that available intensity we have performed a high-precision measurement of the 6He half-life that directly probes the axial part of the nuclear Hamiltonian. Currently, we are preparing a measurement of the beta-neutrino angular correlation in 6He beta decay that will allow to search for new physics beyond the Standard Model in the form of tensor currents. © 2013 AIP Publishing LLC.

Common Fundamental Domains For Lattices Of The Same Volume, Ashley Erwin

Honors Program Theses and Projects

No abstract provided.

Atomic Data For S Ii—Toward Better Diagnostics Of Chemical Evolution In High-Redshift Galaxies, Romas Kisielius, Varsha P. Kulkarni, Gary J. Ferland, Pavel Bogdanovich, Matt L. Lykins

Physics and Astronomy Faculty Publications

Absorption-line spectroscopy is a powerful tool used to estimate element abundances in both the nearby and distant universe. The accuracy of the abundances thus derived is naturally limited by the accuracy of the atomic data assumed for the spectral lines. We have recently started a project to perform new extensive atomic data calculations used for optical/UV spectral lines in the plasma modeling code Cloudy using state of the art quantal calculations. Here, we demonstrate our approach by focussing on S II, an ion used to estimate metallicities for Milky Way interstellar clouds as well as distant damped Lyman-alpha (DLA) and …

Simulating Bipartite Networks To Reflect Uncertainty In Local Network Properties, Ravi Goyal, Joseph Blitzstein, Victor De Gruttola

Harvard University Biostatistics Working Paper Series

No abstract provided.

Variational Methods And Critical Point Theory 2013, Victoria Otero-Espinar, Juan J. Nieto, Donal O'Regan, Kanishka Perera

Mathematics and System Engineering Faculty Publications

[No abstract provided]

Fluorination Of Aromatic Ring Systems, Stephen G. Dimagno

Chemistry Department: Faculty Publications

This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of ¹⁸F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.

Uncovering The Deeply Embedded Active Galactic Nucleus Activity In The Nuclear Regions Of The Interacting Galaxy Arp 299, A Alonso-Herrero, Eric S. Perlman

Aerospace, Physics, and Space Science Faculty Publications

We present mid-infrared (MIR) 8-13 μm spectroscopy of the nuclear regions of the interacting galaxy Arp 299 (IC 694+NGC 3690) obtained with CanariCam (CC) on the 10.4 m Gran Telescopio Canarias (GTC). The high angular resolution (∼0.″3-0.″6) of the data allows us to probe nuclear physical scales between 60 and 120 pc, which is a factor of 10 improvement over previous MIR spectroscopic observations of this system. The GTC/CC spectroscopy displays evidence of deeply embedded active galactic nucleus (AGN) activity in both nuclei. The GTC/CC nuclear spectrum of NGC 3690/Arp 299-B1 can be explained as emission from AGN-heated dust in …

Comparative Water Quality Of Cozine, Gooseneck And Mill Creeks, Shelby Hollenbeck, Emily Isaac, Suzannah Klaniecki, Zach Lea, Meghan Lockwood, Xavier Reed

Papers from ENVS 385 (Research Methods in Environmental Science)

The environmental research methods class of fall 2013 analyzed the water quality of three creeks in the Yamhill (Oregon) Watershed: Cozine, Gooseneck, and Mill Creeks. Our research builds on data collected by previous years' classes (Colahan et al. 2011; Weinbender and Crane 2011; Bailey et al. 2012). The goals of the project were to gain a better understanding of water quality at each site, see how the sites differ, determine causes for any differences, and examine changes in water quality over time. Because Cozine is surrounded by an urban environment, whereas both Gooseneck and Mill are in a rural setting, …

Rigidity And Flexibility Of Protein-Nucleic Acid Complexes, Emily Flynn, Filip Jagodzinski, Sharon Pamela Santana, Ileana Streinu

Computer Science: Faculty Publications

The study of protein-nucleic acid complexes is relevant for the understanding of many biological processes, including transcription, translation, replication, and recombination. The individual molecules in such complexes must be rigid enough to allow geometric matching of complementary shapes, yet sufficiently flexible to perform their functions. © 2013 IEEE.

Mathematical Model Of Dynamic Protein Interactions Regulating P53 Protein Stability For Tumor Suppression, Hua Wang, Guang Peng

Department of Mathematical Sciences Faculty Publications

In the field of cancer biology, numerous genes or proteins form extremely complex regulatory network, which determines cancer cell fate and cancer cell survival. p53 is a major tumor suppressor that is lost in more than 50% of human cancers. It has been well known that a variety of proteins regulate its protein stability, which is essential for its tumor suppressive function. It remains elusive how we could understand and target p53 stabilization process through network analysis. In this paper we discuss the use of random walk and stationary distribution to measure the compound effect of a network of genes …

Designing Optimal Innovation Portfolio, Arcot Desai Narasimhalu

Research Collection School Of Computing and Information Systems

There have been many approaches towards investing in innovation projects. There has been very little discussion about the need to align such investments with the mission, vision, goals, leadership style, value discipline and risk appetite of an organization. This paper reviews existing approaches to innovation related investments and suggests the setting up of a proper innovation portfolio management process along with three dashboards that will help make innovation related investment decisions in an informed manner. The resulting innovation portfolio will be optimal in its alignment with an organizations mission and vision. We expect this method to be used by all …

Application Of Receiver Operating Characteristic (Roc) Curves For Explosives Detection Using Different Sampling And Detection Techniques, Mimy Young, Wen Fan, Anna Raeva, Jose Almirall

Department of Chemistry and Biochemistry

Reported for the first time are receiver operating characteristic (ROC) curves constructed to describe the performance of a sorbent-coated disk, planar solid phase microextraction (PSPME) unit for non-contact sampling of a variety of volatiles. The PSPME is coupled to ion mobility spectrometers (IMSs) for the detection of volatile chemical markers associated with the presence of smokeless powders, model systems of explosives containing diphenylamine (DPA), 2,4-dinitrotoluene (2,4-DNT) and nitroglycerin (NG) as the target analytes. The performance of the PSPME-IMS was compared with the widely accepted solid-phase microextraction (SPME), coupled to a GC-MS. A set of optimized sampling conditions for different volume …

The Progenitors Of The Compact Early-Type Galaxies At High Redshift, Christina C. Williams, Mauro Giavalisco, Paolo Cassata, Elena Tundo, Tommy Wiklind, Yicheng Guo, Bomee Lee, Guillermo Barro, Stijn Wuyts, Eric F. Bell, Christopher J. Conselice, Avishai Dekel, Sandra M. Faber, Henry C. Ferguson, Norman A. Grogin, Nimish Hathi, Kuang-Han Huang, Dalibor D. Kocevski, Anton M. Koekemoer, David C. Koo, Swara Ravindranath, Sarah Salimbeni

Physics and Astronomy Faculty Publications

We use GOODS and CANDELS images to identify progenitors of massive (M > 10¹⁰ M _☉) compact early-type galaxies (ETGs) at z ~ 1.6. Because merging and accretion increase the size of the stellar component of galaxies, if the progenitors are among known star-forming galaxies, these must be compact themselves. We select candidate progenitors among compact Lyman-break galaxies at z ~ 3 on the basis of their mass, star-formation rate (SFR), and central stellar density, and we find that these account for a large fraction of, and possibly all, compact ETGs at z ~ 1.6. We find that …

Using Intelligent Prefetching To Reduce The Energy Consumption Of A Large-Scale Storage System, Brian Romoser, Ziliang Zong, Ribel Fares, Joal Wood, Rong Ge

Mathematics, Statistics and Computer Science Faculty Research and Publications

Many high performance large-scale storage systems will experience significant workload increases as their user base and content availability grow over time. The U.S. Geological Survey (USGS) Earth Resources Observation and Science (EROS) center hosts one such system that has recently undergone a period of rapid growth as its user population grew nearly 400% in just about three years. When administrators of these massive storage systems face the challenge of meeting the demands of an ever increasing number of requests, the easiest solution is to integrate more advanced hardware to existing systems. However, additional investment in hardware may significantly increase the …

The Unexpectedly Bright Comet C/2012 F6 (Lemmon) Unveiled At Near-Infrared Wavelengths, Lucas Paganini, Michael Disanti, Michael Mumma, Geronimo Villanueva, Boncho Bonev, Jacqueline Keane, Erika Gibb, Hermann Boehnhardt, Karen Meech

Physics Faculty Works

We acquired near-infrared spectra of the Oort cloud comet C/2012 F6 (Lemmon) at three different heliocentric distances (R h) during the comet's 2013 perihelion passage, providing a comprehensive measure of the outgassing behavior of parent volatiles and cosmogonic indicators. Our observations were performed pre-perihelion at R h = 1.2 AU with CRIRES (on 2013 February 2 and 4), and post-perihelion at R h = 0.75 AU with CSHELL (on March 31 and April 1) and R h = 1.74 AU with NIRSPEC (on June 20). We detected 10 volatile species (H2O, OH* prompt emission, C2H6, CH3OH, H2CO, HCN, CO, CH4, …

The Crustal Thickness Of West Antarctica, Julien A. Chaput, Richard C. Aster, Audrey D. Huerta, X. Sun, Andrew Lloyd, Douglas A. Wiens, Andrew Nyblade, Sridhar Anandakrishnan, J. Paul Winberry, Terry Wilson

Geological Sciences Faculty Scholarship

P-to-S receiver functions (PRFs) from the Polar Earth Observing Network (POLENET) GPS and seismic leg of POLENET spanning West Antarctica and the Transantarctic Mountains deployment of seismographic stations provide new estimates of crustal thickness across West Antarctica, including the West Antarctic Rift System (WARS), Marie Byrd Land (MBL) dome, and the Transantarctic Mountains (TAM) margin. We show that complications arising from ice sheet multiples can be effectively managed and further information concerning low-velocity subglacial sediment thickness may be determined, via top-down utilization of synthetic receiver function models. We combine shallow structure constraints with the response of deeper layers using a …