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Capacity Constraints For Implementing Environmental Conventions In Jordan, Raed Al-Tabini, M. Shatanawi, R.J. Al-Tabini
Capacity Constraints For Implementing Environmental Conventions In Jordan, Raed Al-Tabini, M. Shatanawi, R.J. Al-Tabini
Raed Al-Tabini
No abstract provided.
Estimating Hydrodynamic Quantities In The Presence Of Microscopic Fluctuations, Alejandro Garcia
Estimating Hydrodynamic Quantities In The Presence Of Microscopic Fluctuations, Alejandro Garcia
Alejandro Garcia
This paper discusses the evaluation of hydrodynamic variables in the presence of spontaneous fluctuations, such as in molecular simulations of fluid flows. The principal point is that hydrodynamic variables such as fluid velocity and temperature must be defined in terms of mechanical variables such as momentum and energy density). Because these relations are nonlinear and because fluctuations of mechanical variables are correlated, care must be taken to avoid introducing a bias when evaluating means, variances, and correlations of hydrodynamic variables. The unbiased estimates are formulated; some alternative, incorrect approaches are presented as cautionary warnings. The expressions are verified by numerical …
Hydrodynamic Description Of The Adiabatic Piston, Alejandro Garcia, Malek M. Mansour
Hydrodynamic Description Of The Adiabatic Piston, Alejandro Garcia, Malek M. Mansour
Alejandro Garcia
A closed macroscopic equation for the motion of the two-dimensional adiabatic piston is derived from standard hydrodynamics. It predicts a damped oscillatory motion of the piston towards a final rest position, which depends on the initial state. In the limit of large piston mass, the solution of this equation is in quantitative agreement with the results obtained from both hard disk molecular dynamics and hydrodynamics. The explicit forms of the basic characteristics of the piston’s dynamics, such as the period of oscillations and the relaxation time, are derived. The limitations of the theory’s validity, in terms of the main system …
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Farnesylated Lamins, Progeroid Syndromes And Farnesyl Transferase Inhibitors, Michael Sinensky, A. E. Rusinol
Michael Sinensky
Three mammalian nuclear lamin proteins, lamin B1, lamin B2 and the lamin A precursor, prelamin A, undergo canonical farnesylation and processing at CAAX motifs. In the case of prelamin A, there is an additional farnesylation-dependent endoproteolysis, which is defective in two congenital diseases: Hutchinson-Gilford progeria (HGPS) and restrictive dermopathy (RD). These two diseases arise respectively from defects in the prelamin A substrate and the enzyme (ZmpSte24) that processes it. Recent work has shed light on the roles of the lamin proteins and the enzymes involved in their farnesylation-dependent maturation. Other experimental work, including mouse model studies, have examined the possibility …
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Dna Damage Responses In Progeroid Syndromes Arise From Defective Maturation Of Prelamin A, Michael Sinensky, Y. Liu, A. Rusinol, Y. Wang, Y. Zou
Michael Sinensky
The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A because of defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms that can be viewed as accelerated aging. The mechanism by which accumulation of farnesylated prelamin A leads to these accelerated aging phenotypes is not understood. Here we present evidence that in HGPS and RD fibroblasts, DNA damage checkpoints are persistently activated because of the compromise in genomic integrity. Inactivation of checkpoint kinases Ataxia-telangiectasia-mutated (ATM) and ATR (ATM- and Rad3-related) in these patient cells can partially overcome their …
High-Resolution Raman Spectra With Femtosecond Pulses: An Example Of Combined Time- And Frequency-Domain Spectroscopy, Sukhendu Nath, Diana Urbanek, Sean Kern, Mark Berg
High-Resolution Raman Spectra With Femtosecond Pulses: An Example Of Combined Time- And Frequency-Domain Spectroscopy, Sukhendu Nath, Diana Urbanek, Sean Kern, Mark Berg
Sean J. Kern
Frequency-domain spectroscopy requires long pulses, whereas time-domain spectroscopy requires short pulses. This Letter demonstrates both theoretically and experimentally that simultaneous detection in frequency and time generates well-resolved spectra using intermediate-length pulses. In the case of coherent Raman spectroscopy, typical femtosecond pulses lie between the time and frequency domains. To demonstrate this method, a high-resolution Raman spectrum of nitrobenzene is obtained from 60 fs pulses. Phase control, pulse shaping, or pulses of widely differing duration are not required.