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Plasma Agriculture: Characterization Of Dbd Plasma Jet And Analysis Of Effects When Treated On Sweet Basil (Ocimum Basilicum), William Davis

Seton Hall University Dissertations and Theses (ETDs)

Plasma agriculture is an increasingly diverse field, where effects of nonthermal or cold plasma are measured by their influence on plant physiology and growth rate. Effects range from sterilization, germination, increased growth rate, cell metabolism, and so forth. This study aims to investigate the understanding of the generation of specific reactive oxygen and nitrogen species (RONS) from a nonthermal atmospheric DBD helium-based plasma jet and identify quantifiable effects that can directly translate to different applications related to plasma agriculture. Basil plants were separated into treated and control groups and grown hydroponically. The treated plants received a 30 second exposure treatment …

Theranostic Applications Of Sirna Bioconjugates In Cancer Detection And Treatment, Sunil S. Shah

Seton Hall University Dissertations and Theses (ETDs)

Abstract

The emerging field of RNA nanotechnology has led to rapid advances in the applications of RNA in chemical biology, medicinal chemistry, and biotechnology. At the forefront of its utility is the ability to self-assemble multiple siRNAs into nanostructure formulations capable of targeting selected oncogenes and potentiating the gene therapy of malignant tumors. Self-assembled siRNA integrates multiple siRNAs within a single molecular platform for silencing multiple oncogenic mRNA targets with high precision and efficacy to potentially induce cancer cell apoptosis through the RNA interference (RNAi) pathway. Furthermore, the conjugation of siRNA self-assemblies with bio-active probes results in multi-functional theranostic (therapy+diagnostic) …

Investigations Into Effects Of Modified Prolines On Cis-Trans Isomers And Polypeptide Secondary Structure & Prediction Of Spectroscopic Properties Of Phthalonitriles For Characterization, Jeffrey Raab

Seton Hall University Dissertations and Theses (ETDs)

Proline is a unique amino acid because it is the only amino acid whose side chain wraps around and bonds back to the peptide backbone. This ring shape helps proteins form conformations which would otherwise not be possible such as hairpin turns. The cis/trans isomerization of the peptide bond between the preceding amino acid (X_aa) and Proline is important in determining how the secondary structure folds. Thus, being able to control the cis/trans isomerization is important when a specific conformation is desired; Proline can be modified to get make the equilibrium shift whichever way is needed. The modifications …