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Reactions Of Platinum(Ii) Compounds With Selenium Containing Amino Acids, Stephanie Robey
Reactions Of Platinum(Ii) Compounds With Selenium Containing Amino Acids, Stephanie Robey
Masters Theses & Specialist Projects
Platinum(II) anticancer medications essentially react with DNA forming kinks in
the double helix of DNA and causing apoptosis. It has also been noted that these
anticancer medications react with methionine and cysteine in the body. With the new discoveries of selenium containing amino acids including selenomethionine and selenocysteine, new research is ongoing to see what types of products can be formed from these amino acids. Our research reacts [Pt(Met-S,N)Cl2] 2+ with selenomethionine to determine what types of products are produced. Monochelates including [Pt(SeMet-Se,N)Cl2] 2+ have formed two isomers, …
Effects Of Cisplatin Analog Size On The Reaction With Dna Bases, Swathi Nandala
Effects Of Cisplatin Analog Size On The Reaction With Dna Bases, Swathi Nandala
Masters Theses & Specialist Projects
Cancer is the second leading cause of death in the United States. Cisplatin is one of the well-known anti-cancer agents used to treat testicular and ovarian cancers. It mainly binds to the DNA bases, which leads to cell death. The cytotoxic activity of the cisplatin analogs is due to the interaction of platinum with nucleotides like adenine at N7 or N1 position and guanine at N7 position. Guanine is the primary target for cisplatin analogs whereas adenine is the secondary target. Cisplatin analogs, [Pt(Me5dien)(D2O)]2+[Me5dien = N,N,N’,N’,N’’-pentamethyl diethylene triamine] and …