Digital Commons Network^™

An Approach To Lunar Regolith Particle Detection And Classification Using Deep Learning, Hira Nadeem

Electronic Thesis and Dissertation Repository

Lunar regolith, unconsolidated rock on the lunar surface, is made up of various particles. Understanding the quantities and locations of these particles on the lunar surface is of particular interest to planetary scientists for mission planning and science objectives. There is a limited supply of lunar regolith samples available on Earth for planetary scientists to characterize. Lunar rover missions over the next decade are expected to provide high-resolution images of the lunar surface. Deep learning can be leveraged to analyze lunar regolith from image data. An object detection model using transfer learning was developed to identify and classify particles of …

Investigating Improvements To Mesh Indexing, Anurag Bhattacharjee

Electronic Thesis and Dissertation Repository

The MEDLINE database currently comprises an extensive collection of over 35 million citations, with more than 1 million records being added each year [28]. The abundance of information available in the database presents a significant challenge in identifying and locating relevant research articles on a given search topic. This has prompted the development of various techniques and approaches aimed at improving the efficiency and effectiveness of information retrieval from the MEDLINE database. A search engine devoted to the research publications on MEDLINE is called PubMed. MeSH, or Medical Subject Headings, is a restricted vocabulary used by PubMed to categorize each …

Denoising-Based Domain Adaptation Network For Eeg Source Imaging, Runze Li

Electronic Thesis and Dissertation Repository

Electrophysiological source imaging (ESI) is a widespread and no-invasive technique in neuroscientific research and clinical diagnostics. It provides a well-established and high temporal resolution of source activity and gives the brain signal by analyzing the corresponding EEG signal.

However, it is still a major challenge to deal with the domain shift problem between the datasets of different subjects or sessions in ESI problem. Furthermore, the variable noise included in the EEG signals inevitably influence the accuracy of localization of source activity.

In this paper, we propose a novel denoising autoencoder-based unsupervised domain adaptation (DAE-UDA) algorithm to tackle these problems. To …

Computational Methods For Predicting Protein-Protein Interactions And Binding Sites, Yiwei Li

Electronic Thesis and Dissertation Repository

Proteins are essential to organisms and participate in virtually every process within cells. Quite often, they keep the cells functioning by interacting with other proteins. This process is called protein-protein interaction (PPI). The bonding amino acid residues during the process of protein-protein interactions are called PPI binding sites. Identifying PPIs and PPI binding sites are fundamental problems in system biology.

Experimental methods for solving these two problems are slow and expensive. Therefore, great efforts are being made towards increasing the performance of computational methods.

We present DELPHI, a deep learning based program for PPI site prediction and SPRINT, an algorithmic …

Discrimination Of Leucine And Isoleucine In De Novo Peptide Sequencing Using Deep Neural Networks, Bingran Shen

Electronic Thesis and Dissertation Repository

De novo peptide sequencing from tandem MS data is a key technology in proteomics for understanding the structure of proteins, especially for first seen sequences. Although this technique has advanced rapidly in recent years and become more effective, one crucial problem remained unsolved. Due to the isomerism of leucine and isoleucine, they are practically indistinguishable in de novo sequencing using traditional tandem MS data. Some experimental attempts have been made to resolve this ambiguity such as EThCD fragmentation process. In this study, we took a data focused approach rather than only looking for characteristic satellite ions produced by the EThCD …

Incorporating Figure Captions And Descriptive Text Into Mesh Term Indexing: A Deep Learning Approach, Xindi Wang

Electronic Thesis and Dissertation Repository

The exponential increase of available documents online makes document classification an important application in natural language processing. The goal of text classification is to automatically assign categories to documents. Traditional text classifiers depend on features, such as, vocabulary and user-specified information which mainly relies on prior knowledge. In contrast, deep learning automatically learns effective features from data instead of adopting human-designed features. In this thesis, we specifically focus on biomedical document classification. Beyond text information from abstract and title, we also consider image and table captions, as well as paragraphs associated with images and tables, which we demonstrate to be …