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An Efficient And Chemoselective Method To Generate Arynes, Bryan Metze, Riley A. Roberts, Aleksandra Nilova, David R. Stuart
An Efficient And Chemoselective Method To Generate Arynes, Bryan Metze, Riley A. Roberts, Aleksandra Nilova, David R. Stuart
Chemistry Faculty Publications and Presentations
Arynes hold immense potential as reactive intermediates in organic synthesis as they engage in a diverse range of mechanistically distinct chemical reactions. However, the poor functional group compatibility of generating arynes or their precursors has stymied their widespread use. Here, we show that generating arynes by deprotonation of an arene and elimination of an “onium” leaving group is mild, efficient and broad in scope. This is achieved by using aryl(TMP)iodonium salts (TMP = 2,4,6-trimethoxyphenyl) as the aryne precursor and potassium phosphate as the base, and a range of arynophiles are compatible. Additionally, we have performed the first quantitative analysis of …
Versatile Bismuth Salts-Induced Reactions From Our Laboratory: A Perspective, Debasish Bandyopadhyay, Bimal Krishna Banik
Versatile Bismuth Salts-Induced Reactions From Our Laboratory: A Perspective, Debasish Bandyopadhyay, Bimal Krishna Banik
Chemistry Faculty Publications and Presentations
Bismuth salts-mediated reactions are developed for the synthesis of diverse organic molecules of medicinal significance. Reactions conducted with bismuth salts are environmentally friendly and these may proceed due to the release of acids in the media. Bismuth salt may also act as a Lewis acid in these reactions. Versatile organic molecules in chiral and achiral forms are synthesized using bismuth salts-induced reactions at our research laboratory.
Expeditious Green Synthesis Of Versatile Organic Compounds By Diverse Methods, Bimal K. Banik
Expeditious Green Synthesis Of Versatile Organic Compounds By Diverse Methods, Bimal K. Banik
Chemistry Faculty Publications and Presentations
Synthesis of organic compounds requires organic solvents and reagents to promote them. Very often, toxic solvents are used for this purpose. Many organic reactions require molar proportion of reactants and reagents to accomplish the goal. Some reactions require longer reaction times and produce products without control of stereochemistry. Therefore, development of facile and effective organic reactions under environmentally friendly conditions is necessary. In this perspective, several reactions are discussed that are performed by microwave-induced reactions, catalytic procedures, in the absence of any solvents, one-pot method and in water. Important reactions are chosen to investigate the feasibility of conducting these reactions …