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Spirobicyclic Diamines 1: Synthesis Of Proline-Derived Spirolactams Via Thermal Intramolecular Ester Aminolysis, Fintan Kelleher, Sinead Kelly

Articles

Proline derived [4.4]-spirolactams have been synthesised in good yields by a reductive-amination reaction followed by thermal cyclisation of the resulting amine onto the proline ester group in refluxing toluene. The synthesis of the corresponding [4.5]-spirolactams by the same method gave much reduced yields.