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Synthesis And Structure Of A Substituted Pyridazine, Kiranmai Byrichetti
Synthesis And Structure Of A Substituted Pyridazine, Kiranmai Byrichetti
Masters Theses & Specialist Projects
Pyridazines are heterocyclic compounds with an N-N bond in their ring structure. Heterocyclic aromatic compounds are of great interest as a result of their novel properties and commercial applications. Our current research is focused on the potential role of pyridazines in next generation electronic devices that utilize organics as the semiconducting material. The synthesis of 5, 6-fused ring pyridazines beginning from fulvenes (Scheme 1) is described herein. These fused heterocycles will serve as synthetic models and building blocks for potential organic or organometallic conducting polymers.
Our goal was to modify the route of Snyder et al. previously reported for the …
Innovative Purification Protocol For Heparin Binding Proteins: Relevance In Biopharmaceutical And Biomedical Applications, Sumit Batra
Masters Theses & Specialist Projects
Heparin binding (HB) proteins mediates a wide range of important cellular processes, which makes this class of proteins biopharmaceutically important. Engineering HB proteins could bring many advantages, but it necessitates cost effective and efficient purification methodologies compared to the currently available methods. One of the most important classes of heparin binding protein is the fibroblast growth factors (FGFs) and its receptors (FGFRs). In this study, we report an efficient off-column purification of FGF-1 from soluble fractions and purification of the D2 domain of FGFR from insoluble inclusion bodies, using a weak amberlite cation (IRC) exchanger. This approach is an alternative …