Digital Commons Network^™

Nicotine Exploits A Copi-Mediated Process For Chaperone-Mediated Up-Regulation Of Its Receptors, Brandon J. Henderson, Rahul Srinivasan, Weston A. Nichols, Crystal N. Dilworth, Diana F. Gutierrez, Elisha D. W. Mackey, Sheri Mckinney, Ryan M. Drenan, Christopher I. Richards, Henry A. Lester

Chemistry Faculty Publications

Chronic exposure to nicotine up-regulates high sensitivity nicotinic acetylcholine receptors (nAChRs) in the brain. This up-regulation partially underlies addiction and may also contribute to protection against Parkinson's disease. nAChRs containing the α6 subunit (α6* nAChRs) are expressed in neurons in several brain regions, but comparatively little is known about the effect of chronic nicotine on these nAChRs. We report here that nicotine up-regulates α6* nAChRs in several mouse brain regions (substantia nigra pars compacta, ventral tegmental area, medial habenula, and superior colliculus) and in neuroblastoma 2a cells. We present evidence that a coat protein complex I (COPI)-mediated process mediates this …

Molecular Hydrogen Regulated Star Formation In Cosmological Smoothed Particle Hydrodynamics Simulations, Robert Thompson, Kentaro Nagamine, Jason Jaacks, Jun-Hwan Choi

Physics and Astronomy Faculty Publications

Some observations have shown that star formation (SF) correlates tightly with the presence of molecular hydrogen (H₂); therefore, it is important to investigate its implication on galaxy formation in a cosmological context. In the present work, we implement a sub-grid model (hereafter H₂-SF model) that tracks the H₂ mass fraction within our cosmological smoothed particle hydrodynamics code GADGET-3 by using an equilibrium analytic model of Krumholz et al. This model allows us to regulate the SF in our simulation by the local abundance of H₂ rather than the total cold gas density, which naturally …

Atomic Data For S Ii—Toward Better Diagnostics Of Chemical Evolution In High-Redshift Galaxies, Romas Kisielius, Varsha P. Kulkarni, Gary J. Ferland, Pavel Bogdanovich, Matt L. Lykins

Physics and Astronomy Faculty Publications

Absorption-line spectroscopy is a powerful tool used to estimate element abundances in both the nearby and distant universe. The accuracy of the abundances thus derived is naturally limited by the accuracy of the atomic data assumed for the spectral lines. We have recently started a project to perform new extensive atomic data calculations used for optical/UV spectral lines in the plasma modeling code Cloudy using state of the art quantal calculations. Here, we demonstrate our approach by focussing on S II, an ion used to estimate metallicities for Milky Way interstellar clouds as well as distant damped Lyman-alpha (DLA) and …

The Progenitors Of The Compact Early-Type Galaxies At High Redshift, Christina C. Williams, Mauro Giavalisco, Paolo Cassata, Elena Tundo, Tommy Wiklind, Yicheng Guo, Bomee Lee, Guillermo Barro, Stijn Wuyts, Eric F. Bell, Christopher J. Conselice, Avishai Dekel, Sandra M. Faber, Henry C. Ferguson, Norman A. Grogin, Nimish Hathi, Kuang-Han Huang, Dalibor D. Kocevski, Anton M. Koekemoer, David C. Koo, Swara Ravindranath, Sarah Salimbeni

Physics and Astronomy Faculty Publications

We use GOODS and CANDELS images to identify progenitors of massive (M > 10¹⁰ M _☉) compact early-type galaxies (ETGs) at z ~ 1.6. Because merging and accretion increase the size of the stellar component of galaxies, if the progenitors are among known star-forming galaxies, these must be compact themselves. We select candidate progenitors among compact Lyman-break galaxies at z ~ 3 on the basis of their mass, star-formation rate (SFR), and central stellar density, and we find that these account for a large fraction of, and possibly all, compact ETGs at z ~ 1.6. We find that …

Effects Of External Radiation Fields On Line Emission—Application To Star-Forming Regions, Marios Chatzikos, Gary J. Ferland, R. J. R. Williams, Ryan Porter, P. A. M. Vanhoof

Physics and Astronomy Faculty Publications

A variety of astronomical environments contain clouds irradiated by a combination of isotropic and beamed radiation fields. For example, molecular clouds may be irradiated by the isotropic cosmic microwave background, as well as by a nearby active galactic nucleus. These radiation fields excite atoms and molecules and produce emission in different ways. We revisit the escape probability theorem and derive a novel expression that accounts for the presence of external radiation fields. We show that when the field is isotropic the escape probability is reduced relative to that in the absence of external radiation. This is in agreement with previous …

Broadcasting With Prediction And Selective Forwarding In Vehicular Networks, Jainjun Yang, Zongming Fei

Computer Science Faculty Publications

Broadcasting in vehicular networks has attracted great interest in research community and industry. Broadcasting on disseminating information to individual vehicle beyond the transmission range is based on inter-vehicle communication systems. It is crucial to broadcast messages to other vehicles as fast as possible because the messages in vehicle communication systems are often emergency messages such as accident warning or alarm. In many current approaches, the message initiator or sender selects the node among its neighbors that is farthest away from it in the broadcasting direction and then assigns the node to rebroadcast the message once the node gets out of …

Thiol-Containing Compounds For The Removal Of Elements From Tissues And Formulations Therefor, Boyd E. Haley, David A. Atwood, Niladri Gupta

Chemistry Faculty Patents

Methods and pharmaceutical formulations for ameliorating heavy metal toxicity and/or oxidative stress are disclosed, comprising administering pharmaceutically effective amounts of ligands according to the present disclosure.

To see the remainder of the abstract, please download this patent.

Approximate Techniques In Solving Optimal Camera Placement Problems, Jian Zhao, Ruriko Yoshida, Sen-Ching Samson Cheung, David Haws

Statistics Faculty Publications

While the theoretical foundation of the optimal camera placement problem has been studied for decades, its practical implementation has recently attracted significant research interest due to the increasing popularity of visual sensor networks. The most flexible formulation of finding the optimal camera placement is based on a binary integer programming (BIP) problem. Despite the flexibility, most of the resulting BIP problems are NP-hard and any such formulations of reasonable size are not amenable to exact solutions. There exists a myriad of approximate algorithms for BIP problems, but their applications, efficiency, and scalability in solving camera placement are poorly understood. Thus, …

Combining Functions And The Closure Principle For Performing Follow-Up Tests In Functional Analysis Of Variance, Olga A. Vsevolozhskaya, Mark C. Greenwood, G. J. Bellante, S. L. Powell, R. L. Lawrence, K. S. Repasky

Olga A. Vsevolozhskaya

Functional analysis of variance involves testing for differences in functional means across kk groups in nn functional responses. If a significant overall difference in the mean curves is detected, one may want to identify the location of these differences. Cox and Lee (2008) proposed performing a point-wise test and applying the Westfall–Young multiple comparison correction. We propose an alternative procedure for identifying regions of significant difference in the functional domain. Our procedure is based on a region-wise test and application of a combining function along with the closure multiplicity adjustment principle. We give an explicit formulation of how to implement …

Upland Habitat Quality And Historic Landscape Composition Influence Genetic Variation Of A Pond-Breeding Salamander, Stephen C. Richter, Steve J. Price, Chelsea S. Kross, Jeremiah R. Alexander, Michael E. Dorcas

Forestry and Natural Resources Faculty Publications

Understanding the temporal and spatial scale at which habitat alteration impacts populations is important for conservation and management. Amphibians have declined more than other vertebrates, and pond-breeding species are particularly susceptible to habitat loss and fragmentation because they have terrestrial and aquatic life stages. One approach to management of pond-breeding species is protection of core upland habitat surrounding the breeding pond. We used genetic variation as an indicator of population status in a common amphibian species, spotted salamanders (Ambystoma maculatum), to determine how amount of suitable upland habitat relates to population status in the greater Charlotte, North Carolina, …

Detecting The Rapidly Expanding Outer Shell Of The Crab Nebula: Where To Look, Xiang Wang, Gary J. Ferland, J. A. Baldwin, E. D. Loh, C. T. Richardson

Physics and Astronomy Faculty Publications

We present a range of steady-state photoionization simulations, corresponding to different assumed shell geometries and compositions, of the unseen postulated rapidly expanding outer shell to the Crab Nebula. The properties of the shell are constrained by the mass that must lie within it, and by limits to the intensities of hydrogen recombination lines. In all cases the photoionization models predict very strong emissions from high ionization lines that will not be emitted by the Crab's filaments, alleviating problems with detecting these lines in the presence of light scattered from brighter parts of the Crab. The near-NIR [Ne VI] λ7.652 μ …

The Deep2 Galaxy Redshift Survey: Design, Observations, Data Reduction, And Redshifts, Jeffery A. Newman, Michael C. Cooper, Marc Davis, S. M. Faber, Alison L. Coil, Puragra Guhathakurta, David C. Koo, Andrew C. Phillips, Charlie Conroy, Aaron A. Dutton, Douglas P. Finkbeiner, Brian F. Gerke, David J. Rosario, Benjamin J. Weiner, Renbin Yan, Justin J. Harker, Susan A. Kassin, N. P. Konidaris, Kamson Lai, Darren S. Madgwick, K. G. Noeske, Gregory D. Wirth, A. J. Connolly, N. Kaiser, Evan N. Kirby, Brian C. Lemaux, Lihwai Lin, Jennifer M. Lotz, G. A. Luppino, C. Marinoni

Physics and Astronomy Faculty Publications

We describe the design and data analysis of the DEEP2 Galaxy Redshift Survey, the densest and largest high-precision redshift survey of galaxies at z ~ 1 completed to date. The survey was designed to conduct a comprehensive census of massive galaxies, their properties, environments, and large-scale structure down to absolute magnitude M_B = –20 at z ~ 1 via ~90 nights of observation on the Keck telescope. The survey covers an area of 2.8 deg² divided into four separate fields observed to a limiting apparent magnitude of R_AB = 24.1. Objects with z ≲ 0.7 are readily …

Supermassive Black Hole Formation At High Redshifts Via Direct Collapse: Physical Processes In The Early Stage, Jun-Hwan Choi, Isaac Shlosman, Mitchell C. Begelman

Physics and Astronomy Faculty Publications

We use numerical simulations to explore whether direct collapse can lead to the formation of supermassive black hole (SMBH) seeds at high redshifts. Using the adaptive mesh refinement code ENZO, we follow the evolution of gas within slowly tumbling dark matter (DM) halos of M_vir ~ 2 × 10⁸ M_☉ and R_vir ~ 1 kpc. For our idealized simulations, we adopt cosmologically motivated DM and baryon density profiles and angular momentum distributions. Our principal goal is to understand how the collapsing flow overcomes the centrifugal barrier and whether it is subject to fragmentation which can potentially …

Thimerosal Exposure And The Role Of Sulfation Chemistry And Thiol Availability In Autism, Janet K. Kern, Boyd E. Haley, David A. Geier, Lisa K. Sykes, Paul G. King, Mark R. Geier

Chemistry Faculty Publications

Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of the children experience a developmental regression characterized by a loss of previously acquired skills and abilities. Typically reported are losses of verbal, nonverbal, and social abilities. Several recent studies suggest that children diagnosed with an ASD have abnormal sulfation chemistry, limited thiol availability, and decreased glutathione (GSH) reserve capacity, resulting in a compromised oxidation/reduction (redox) and detoxification capacity. Research indicates that the availability of thiols, particularly GSH, can influence the effects of thimerosal (TM) and other mercury (Hg) compounds. TM is an organomercurial compound (49.55% Hg …

Long-Term Spectral Evolution Of Tidal Disruption Candidates Selected By Strong Coronal Lines, Chen-Wei Yang, Ting-Gui Wang, Gary J. Ferland, Weimin Yuan, Hong-Yan Zhou, Peng Jiang

Physics and Astronomy Faculty Publications

We present results of follow-up optical spectroscopic Multi-Mirror Telescope (MMT) observations of seven rare, extreme coronal line-emitting galaxies reported by Wang et al. Large variations in coronal lines are found in four objects, making them strong candidates for tidal disruption events (TDEs). For the four TDE candidates, all the coronal lines with ionization states higher than [Fe VII] disappear within 5-9 yr. The [Fe VII] line faded by a factor of about five in one object (J0952+2143) within 4 yr, whereas the line emerged in another two objects that previously did not show the line. A strong increment in the …

Constraints On Oh Megamaser Excitation From A Survey Of Oh Satellite Lines, James Mcbride, Carl Heiles, Moshe Elitzur

Physics and Astronomy Faculty Publications

We report the results of a full-Stokes survey of all four 18 cm OH lines in 77 OH megamasers (OHMs) using the Arecibo Observatory. This is the first survey of OHMs that included observations of the OH satellite lines; only four of the 77 OHMs have existing satellite line observations in the literature. Satellite line emission is detected in five sources, three of which are redetections of previously published sources. The two sources with new detections of satellite line emission are IRAS F10173+0829, which was detected at 1720 MHz, and IRAS F15107+0724, for which both the 1612 MHz and 1720 …

Interstellar H2O Masers From J Shocks, David Hollenbach, Moshe Elitzur, Christopher F. Mckee

Physics and Astronomy Faculty Publications

We present a model in which the 22 GHz H₂O masers observed in star-forming regions occur behind shocks propagating in dense regions (preshock density n ₀ ~ 10⁶-10⁸ cm^–3). We focus on high-velocity (v_s ≳ 30 km s^–1) dissociative J shocks in which the heat of H₂ re-formation maintains a large column of ~300-400 K gas; at these temperatures the chemistry drives a considerable fraction of the oxygen not in CO to form H₂O. The H₂O column densities, the hydrogen densities, and the warm …

Influence Of Media Composition On The Growth Rate Of Chlorella Vulgaris And Scenedesmus Acutus Utilized For Co2 Mitigation, Czarena L. Crofcheck, Xinyi E, Aubrey Shea, Michael D. Montross, Mark Crocker, Rodney Andrews

Biosystems and Agricultural Engineering Faculty Publications

Atmospheric carbon dioxide levels have increased since the industrial revolution due to increasing combustion of fossil fuels. One possible CO₂ mitigation strategy is the use of microalgae for mitigation of CO₂. This paper focuses on the influence of media composition on the growth rate of two microalgae strains, Chlorella vulgaris and Scenedesmus actus. A KNO₃ based medium was found to work better for Chlorella, while a urea based equivalent worked better for Scenedesmus. The urea based media investigated here resulted in growth similar to that found with previously reported KNO₃ based media. …

2,2',5',6-Tetrachloro-4-[(1S)-1-Methylpropoxy]Biphenyl, Hans-Joachim Lehmler, Huimin Wu, Sean Parkin

Chemistry Faculty Publications

In the title molecule, C₁₆H₁₄Cl₄O, the dihedral angle between the least-square planes of the benzene rings is 84.40 (7)°. No unusual intermolecular interactions are present.

Coupled Flow Field Simulations Of Charring Ablators With Nonequilibrium Surface Chemistry, Hicham Alkandry, Iain D. Boyd, Alexandre Martin

Mechanical Engineering Faculty Publications

This paper describes the coupling of a Navier-Stokes solver to a material response code to simulate nonequilibrium gas-surface interactions. The Navier-Stokes solver used in this study is LeMANS, which is a three-dimensional computational fluid dynamics code that can simulate hypersonic reacting flows including thermo-chemical nonequilibrium effects. The material response code employed in this study is MOPAR, which uses the one-dimensional control volume nite-element method to model heat conduction and pyrolysis gas behavior. This coupling is demonstrated using a test case based on the Stardust sample return capsule. Coupled simulations are performed at three different trajectory conditions. The effects of the …

Volume Averaged Modeling Of The Oxidation Of Porous Carbon Fiber Material, Alexandre Martin

Mechanical Engineering Faculty Publications

Charring ablators remain the premium choice for space exploration missions that involve atmospheric re-entry. This type of ablative material is composed of a carbon matrix, usually made of fibers, which is then impregnated with a resin. During re-entry, the high heat flux produced by convective heating causes the material to chemically react. First, the resin pyrolyzes, and is vaporized into a gas that travels through the material, and is eventually ejected at the surface. Then, as the temperature rises, the surface of the porous matrix recess through ablative processes. For re-entry conditions typical of space exploration missions, this is mainly …

Flow-Tube Oxidation Experiments On The Carbon Preform Of Pica, Francesco Panerai, Alexandre Martin, Nagi N. Mansour, Steven A. Sepka, Jean Lachaud

Mechanical Engineering Faculty Publications

Oxidation experiments on the carbon preform of a phenolic-impregnated carbon ablator were performed in the NASA Ames ow-tube reactor facility, at temperatures between 700 and 1300 K, under dry air gas at pressures between 103 and 104 Pa. Mass loss, volumetric recession and density changes were measured at different test conditions. An analysis of the diffusion/reaction competition within the porous material, based on the Thiele number, allowed us to identify low temperature and low pressure conditions to be dominated by in-depth volume oxidation. Experiments above 1000 K were found at transition conditions, where diffusion and reaction occur at similar scales. …

Multi-Dimensional Modeling Pyrolysis Gas Flow Inside Charring Ablators, Haoyue Weng, Alexandre Martin

Mechanical Engineering Faculty Publications

Using an ablative thermal/material response code, the importance of three-dimensionality for modeling ablative test-article is addressed. In particular, the simulation of the pyrolysis gas flow inside a porous material is presented, using two different geometries. The effects of allowing the gas to flow out of the side wall are especially highlighted. Results show that the flow inside the test-article is complex, and that the 0D or 1D assumption made in most Material Response (MR) codes might not be valid for certain geometries.

Studies Of Ngc 6720 With Calibrated Hst/Wfc3 Emission-Line Filter Images. Iii. Tangential Motions Using Astrodrizzle Images, C. R. O'Dell, Gary J. Ferland, W. J. Henney, M. Peimbert

Physics and Astronomy Faculty Publications

We have been able to compare with astrometric precision AstroDrizzle processed images of NGC 6720 (the Ring Nebula) made using two cameras on the Hubble Space Telescope. The time difference of the observations was 12.925 yr. This large time base allowed the determination of tangential velocities of features within this classic planetary nebula. Individual features were measured in [N II] images as were the dark knots seen in silhouette against background nebular [O III] emission. An image magnification and matching technique was also used to test the accuracy of the usual assumption of homologous expansion. We found that homologous …

5,5'-Dichloro-2,2'-Dimethoxybiphenyl, Hans-Joachim Lehmler, Huimin Wu, Sean Parkin

Chemistry Faculty Publications

In the title molecule, C₁₄H₁₂Cl₂O₂, the dihedral angle between the least-square planes of the benzene rings is 62.17 (6)°. Both methoxy groups are slightly out of the plane of the benzene rings to which they are attached, making dihedral angles of 4.22 (18) and 18.82 (16)°.

Method Of Ameliorating Oxidative Stress And Supplementing The Diet, Boyd E. Haley, Niladrl Narayan Gupta

Chemistry Faculty Patents

A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a chemical structure . . .

To see the remainder of this abstract, please download this patent.

Suppression Of Dielectronic Recombination Due To Finite Density Effects, D. Nikolić, T. W. Gorczyca, K. T. Korista, Gary J. Ferland, N. R. Badnell

Physics and Astronomy Faculty Publications

We have developed a general model for determining density-dependent effective dielectronic recombination (DR) rate coefficients in order to explore finite-density effects on the ionization balance of plasmas. Our model consists of multiplying by a suppression factor those highly-accurate total zero-density DR rate coefficients which have been produced from state-of-the-art theoretical calculations and which have been benchmarked by experiment. The suppression factor is based upon earlier detailed collision-radiative calculations which were made for a wide range of ions at various densities and temperatures, but used a simplified treatment of DR. A general suppression formula is then developed as a function of …

Expanded Iron Uta Spectra—Probing The Thermal Stability Limits In Agn Clouds, Gary J. Ferland, R. Kisielius, F. P. Keenan, P. A. M. Van Hoof, V. Jonauskas, Matt L. Lykins, R. L. Porter, R. J. R. Williams

Physics and Astronomy Faculty Publications

The Fe unresolved transition arrays (UTAs) produce prominent features in the ~15-17 Å wavelength range in the spectra of active galactic nuclei (AGNs). Here, we present new calculations of the energies and oscillator strengths of inner-shell lines from Fe XIV, Fe XV, and Fe XVI. These are crucial ions since they are dominant at inflection points in the gas thermal stability curve, and UTA excitation followed by autoionization is an important ionization mechanism for these species. We incorporate these, and data reported in previous papers, into the plasma simulation code Cloudy. This updated physics is subsequently employed to reconsider the …

3,4',5-Trichlorobiphenyl-4-Yl 2,2,2-Trichloroethyl Sulfate, Hans-Joachim Lehmler, Xianran He, Michael W. Duffel, Sean Parkin

Chemistry Faculty Publications

Crystals of the title compound, C₁₄H₈Cl₆O₄S, are twinned by inversion, with unequal components [0.85 (3):0.15 (3)]. The asymmetric unit contains two independent molecules that are related by a pseudo-inversion center. The C_ar-O [1.393 (9) and 1.397 (9) Å] and ester S-O bond lengths [1.600 (5) and 1.590 (5) Å] of both molecules are comparable to the structurally related 2,3,5,5-trichlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. The dihedral angles between the benzene rings in the two molecules are 37.8 (2) and 35.0 (2)°.

Poster Session, Kentucky Water Resources Research Institute, University Of Kentucky

Kentucky Water Resources Annual Symposium

• The New Kentucky Nitrogen and Phosphorus Risk Assessment Tool to Protect Water Quality, Tibor Horvath and others, USDA-NRCS, Lexington, KY
• Groundwater Phosphorus in Kentucky Relative to Karst, Groundwater Sensitivity, and Groundwater Physiographic Region, Caroline Chan, Kentucky Division of Water, Frankfort, KY
• Comparison of Irrigation Scheduling Based on Daily Water Use or Plant Water Demand of Container Grown Nursery Plants, Susmitha Nambuthiri and others, Dept of Horticulture, UK
• Arsenic Species in Broiler (Gallus gallus domesticus) Litter, Soils, Maize (Zea mays L.), and Groundwater from Litter-Amended Fields, Georgia Zeigler and others, Dept Plant and Soil Science, UK
• Cyberinfrastructure …