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Polyethylene Glycol Containing Rompolymers For The Modification Of Neuro-Protective Hemoglobin, Andrea L. Mccollum
Polyethylene Glycol Containing Rompolymers For The Modification Of Neuro-Protective Hemoglobin, Andrea L. Mccollum
Honors College Theses
Polyethylene glycol (PEG) has shown the ability to improve compatibility when used in combination with cell-free hemoglobin in the treatment of traumatic brain injuries. It has been demonstrated that the covalently bonded PEG increases the hydrodynamic radius of the hemoglobin and hence generates a physical barrier while slowing down the oxygen delivery of the strongly oxidative hemoglobin. In this context, I have been working on the development of synthetic pathways to incorporate PEG into monomers and polymers through both direct modification of (7-oxa)norbornene derivatives and post polymerization modification. Starting from the (7-oxa)norbornene anhydride derivatives, we have developed pathways to cationic …
Dipole Bound Excited States Of Polycyclic Aromatic Hydrocarbons Containing Nitrogen And Their Relation To The Interstellar Medium, Mallory L. Theis
Dipole Bound Excited States Of Polycyclic Aromatic Hydrocarbons Containing Nitrogen And Their Relation To The Interstellar Medium, Mallory L. Theis
Honors College Theses
Polycyclic aromatic hydrocarbons (PAHs) are the most abundant type of molecule present in the interstellar medium (ISM). It has been hypothesized that nitrogen replacement within a ring is likely for PAHs present in the ISM. Additionally, electrons, protons, and hydrogen atoms are readily added to or removed from PAHs creating a truly diverse set of chemistries in various interstellar regions. The presence of a nitrogen within a PAH (called a PANH herein) that is additionally dehydrogenated leads to a neutral radical with a large dipole moment. It has recently been shown through the use of high-level quantum chemical computations for …
Detection Of Heavy Transition Metal Cations Using Novel Chemosensors, Shannon Rhodes
Detection Of Heavy Transition Metal Cations Using Novel Chemosensors, Shannon Rhodes
Honors College Theses
Transition metals (TM) are found in the environment and living systems. When present in excess, these metals can trigger health problems, which include memory loss and cognitive functions. In this project, commercially-available compounds were used to aid in the making of novel mono- and di-triazole molecular sensors with a well-known reaction called “click chemistry”. These sensors were used efficiently and selectively to attract a specific metal like iron III, copper, and zinc. Six sensors were tested via UV-spectroscopy, NMR, and fluorescence with the cations and selectivity increased as the sensors were altered.
Analysis Of Resource Allocation Through Game Theory, Brittney L. Benzio
Analysis Of Resource Allocation Through Game Theory, Brittney L. Benzio
Honors College Theses
Game theory presents a set of decision-makers in a model in order to simulate how they will interact according to a set of rules. The game is set up with a set of players, actions, and preferences. The model allows each player to, in some way, be affected by the actions of all players. Nash equilibrium illustrates that the best action for any given player depends on the other players’ actions, and so, each player must make some assumption about what the competition will do. The goal of this project is to model situations of different car companies to improve …
Photodynamic Cancer Therapy A Study Of The Photolysis Reaction Between Porphyrin And 9,10-Diphenylanthracene, James Z. Akins
Photodynamic Cancer Therapy A Study Of The Photolysis Reaction Between Porphyrin And 9,10-Diphenylanthracene, James Z. Akins
Honors College Theses
Photodynamic therapy (PDT) is a method of combating cancerous tumors. PDT works when certain molecules called photosensitizers absorb light and transfer that energy to dissolved oxygen in solution. Next, this singlet oxygen will interfere with nearby molecules that are necessary for cancer cells to function. This research focuses on the kinetics (rates) of the reaction with respect to the photosensitizer, light, and the target molecule. A laser set at 514nm was used in photolysis with the photosensitizer 5,10,15,20-Tetrakis(2,3,5,6-tetrafluorophenyl)porphyrin (TPP). To mimic cancer cells and monitor the effectiveness of the chosen photosensitizer, 9,10-Diphenylanthracene (DPA) was used as the target molecule. In …