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Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Identification Of Disufide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Faculty Research & Creative Activity
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.
Identification Of Disulfide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Identification Of Disulfide Bond Formation Between Mitoneet And Glutamate Dehydrogenase 1, Morgan E. Roberts, Jacquelyn P. Crail, Megan M. Laffoon, William G. Fernandez, Michael A. Menze, Mary E. Konkle
Faculty Research & Creative Activity
MitoNEET is a protein that was identified as a drug target for diabetes, but its cellular function as well as its role in diabetes remains elusive. Protein pull-down experiments identified glutamate dehydrogenase 1 (GDH1) as a potential binding partner. GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator. Proteomic analysis identified the specific cysteine residues that participate in the disulfide bond. This is the first report that effectively links mitoNEET to activation of the insulin regulator GDH1.
Home Rule And Environmentalism: The Adoption Of Green Initiatives In U.S. Municipalities, Luke Eastin
Home Rule And Environmentalism: The Adoption Of Green Initiatives In U.S. Municipalities, Luke Eastin
2013 Awards for Excellence in Student Research & Creative Activity - Documents
In recent years there has been a movement in academia from studying environmental policy on the national level to a much narrower examination of local municipalities and their respective green initiatives. The implications of this research reach well beyond the borders of academics and hit squarely municipalities and their corresponding local policy makers. We, as political scientists, must ask what particular characteristics of municipalities play the most significant role in green initiative adoption. Recent urban scholarship has suggested several variables that influence the adoption of environmental policies, but one specific variable, municipality home rule status, has had little to no …
Determining The Sediment Source Area Through Petrographic Analysis Of The Hermosa Formation, Silverton, Southwestern Co, Kristina P. Pourtabib
Determining The Sediment Source Area Through Petrographic Analysis Of The Hermosa Formation, Silverton, Southwestern Co, Kristina P. Pourtabib
Undergraduate Honors Theses
The Pennsylvanian/Permian Hermosa Formation in southwestern Colorado is composed of arkosic sandstone, marine limestone, and shale that formed at a time when the region consisted of open-marine carbonate shelves and coastal plains. During the time of deposition, there were many tectonically active highlands in the region, including the Ancestral Rocky Mountains, San Luis Highlands, and the Uncompahgre, Emery, Zuni-Defiance-Kaibab Uplifts. Previous studies have attributed the source of the main sediment supply of the Hermosa Formation to the Uncompahgre branch of the Ancestral Rocky Mountains with smaller amounts of elastics from the Defiance-Zuni uplifts (Wengerd and Matheny, 1958; Wengerd and Strickland, …
Symmetric Random Walks On Homeo+(R), B. Deroin, V. Klepstyn, A. Navas, Kamlesh Parwani
Symmetric Random Walks On Homeo+(R), B. Deroin, V. Klepstyn, A. Navas, Kamlesh Parwani
Faculty Research and Creative Activity
We study symmetric random walks on finitely generated groups of orientation-preserving homeomorphisms of the real line. We establish an oscillation property for the induced Markov chain on the line that implies a weak form of recurrence. Except for a few special cases, which can be treated separately, we prove a property of "global stability at a finite distance": roughly speaking, there exists a compact interval such that any two trajectories get closer and closer whenever one of them returns to the compact interval. The probabilistic techniques employed here lead to interesting results for the study of group actions on the …
A Gentle Introduction To Pythontex, Andrew Mertz, William Slough
A Gentle Introduction To Pythontex, Andrew Mertz, William Slough
Faculty Research and Creative Activity
No abstract provided.
High-Pressure Cryogelation Of Nanosilica And Surface Properties Of Cryosilicas, V Gun'ko, V Turov, V Zarko, G Prykhod'ko, O Remez, R Leboda, J Skubiszewska-Zieba, E Pahklov, Jonathan Blitz
High-Pressure Cryogelation Of Nanosilica And Surface Properties Of Cryosilicas, V Gun'ko, V Turov, V Zarko, G Prykhod'ko, O Remez, R Leboda, J Skubiszewska-Zieba, E Pahklov, Jonathan Blitz
Faculty Research and Creative Activity
Silica cryogels (cryosilicas) in a powder state were synthesized with different concentrations of fumed silica A-300 (CA-300 = 5-20 wt.%), sonicated in aqueous suspension, then frozen at -14 oC at different pressures in a high-pressure stainless steel reactor (a freezing bomb), and dried in air at room temperature. To analyze the effects of low temperature and high pressure, samples were also prepared at -14 oC or room temperature and standard pressure. The structural and adsorption properties of the powder materials were studied using nitrogen adsorption, high-resolution transmission electron microscopy, infrared spectroscopy, thermogravimetry, low-temperature 1H NMR spectroscopy and thermally stimulated depolarization …
High-Pressure Cryogelation Of Nanosilica And Surface Properties Of Cryosilicas, V M. Gun'ko, V V. Turov, V I. Zarko, G P. Prykhod'ko, O S. Remez, R Leboda, J Skubiszewska-Zieba, E M. Pahklov, Jonathan Blitz
High-Pressure Cryogelation Of Nanosilica And Surface Properties Of Cryosilicas, V M. Gun'ko, V V. Turov, V I. Zarko, G P. Prykhod'ko, O S. Remez, R Leboda, J Skubiszewska-Zieba, E M. Pahklov, Jonathan Blitz
Faculty Research and Creative Activity
Silica cryogels (cryosilicas) in a powder state were synthesized with different concentrations of fumed silica A-300 (CA-300 = 5-20 wt.%), sonicated in aqueous suspension, then frozen at -14 oC at different pressures in a high-pressure stainless steel reactor (a freezing bomb), and dried in air at room temperature. To analyze the effects of low temperature and high pressure, samples were also prepared at -14 oC or room temperature and standard pressure. The structural and adsorption properties of the powder materials were studied using nitrogen adsorption, high-resolution transmission electron microscopy, infrared spectroscopy, thermogravimetry, low-temperature 1H NMR spectroscopy and thermally stimulated depolarization …
Symmetric Random Walks On Homeo+(R), B. Deroin, V. Klepstyn, A. Navas, Kamlesh Parwani
Symmetric Random Walks On Homeo+(R), B. Deroin, V. Klepstyn, A. Navas, Kamlesh Parwani
Faculty Research and Creative Activity
We study symmetric random walks on finitely generated groups of orientation-preserving homeomorphisms of the real line. We establish an oscillation property for the induced Markov chain on the line that implies a weak form of recurrence. Except for a few special cases, which can be treated separately, we prove a property of "global stability at a finite distance": roughly speaking, there exists a compact interval such that any two trajectories get closer and closer whenever one of them returns to the compact interval. The probabilistic techniques employed here lead to interesting results for the study of group actions on the …