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Γ-Butyrobetaine Is A Proatherogenic Intermediate In Gut Microbial Metabolism Of L-Carnitine To Tmao, Robert A. Koeth, Bruce S. Levison, Miranda K. Culley, Jennifer A. Buffa, Zeneng Wang, Jill C. Gregory, Elin Org, Yuping Wu, Lin Li, Jonathan D. Smith, W.H. Wilson Tang, Joseph A. Didonato, Aldons J. Lusis, Stanley L. Hazen
Γ-Butyrobetaine Is A Proatherogenic Intermediate In Gut Microbial Metabolism Of L-Carnitine To Tmao, Robert A. Koeth, Bruce S. Levison, Miranda K. Culley, Jennifer A. Buffa, Zeneng Wang, Jill C. Gregory, Elin Org, Yuping Wu, Lin Li, Jonathan D. Smith, W.H. Wilson Tang, Joseph A. Didonato, Aldons J. Lusis, Stanley L. Hazen
Mathematics and Statistics Faculty Publications
L-carnitine, a nutrient in red meat, was recently reported to accelerate atherosclerosis via a metaorganismal pathway involving gut microbial trimethylamine (TMA) formation and host hepatic conversion into trimethylamine-N-oxide (TMAO). Herein, we show that following L-carnitine ingestion, γ-butyrobetaine (γBB) is produced as an intermediary metabolite by gut microbes at a site anatomically proximal to and at a rate ∼1,000-fold higher than the formation of TMA. Moreover, we show that γBB is the major gut microbial metabolite formed from dietary L-carnitine in mice, is converted into TMA and TMAO in a gut microbiota-dependent manner (like dietary L-carnitine), and accelerates atherosclerosis. Gut microbial …
Prognostic Value Of Estimated Functional Capacity Incremental To Cardiac Biomarkers In Stable Cardiac Patients, W.H. Wilson Tang, Eric J. Topol, Yiying Fan, Yuping Wu, Leslie Cho, Cindy Stevenson, Stephen G. Ellis, Stanley L. Hazen
Prognostic Value Of Estimated Functional Capacity Incremental To Cardiac Biomarkers In Stable Cardiac Patients, W.H. Wilson Tang, Eric J. Topol, Yiying Fan, Yuping Wu, Leslie Cho, Cindy Stevenson, Stephen G. Ellis, Stanley L. Hazen
Mathematics and Statistics Faculty Publications
Background: Few studies have investigated functional capacity self-assessment tools in either prediction of future major adverse cardiac outcomes beyond all-cause mortality or direct comparisons with clinically available biomarkers. Methods and Results: We estimated functional capacity using the Duke Activity Status Index (DASI) questionnaire in 8987 sequential stable patients without acute coronary syndrome who were undergoing elective diagnostic coronary angiography with 3-year follow-up of major adverse cardiac events (death, nonfatal myocardial infarction, or stroke). A low DASI score provided independent prediction of a 4.8-fold increase in future risk of incident major adverse cardiac events at 3 years (quartiles 1 versus 4 …
Diagnosis Of Infection After Splenectomy For Trauma Should Be Based On Lack Of Platelets Rather Than White Blood Cell Count, Aman Banerjee, Katherine B. Kelly, Hannah Y. Zhou, Shanteria D. Dixon, Ariadni Papana Dagiasis, Linda M. Quinn, Jeffrey A. Claridge
Diagnosis Of Infection After Splenectomy For Trauma Should Be Based On Lack Of Platelets Rather Than White Blood Cell Count, Aman Banerjee, Katherine B. Kelly, Hannah Y. Zhou, Shanteria D. Dixon, Ariadni Papana Dagiasis, Linda M. Quinn, Jeffrey A. Claridge
Mathematics and Statistics Faculty Publications
Background: There is a lack of evidence-based criteria to assist the diagnosis of infection following trauma splenectomy (TS). However, the literature suggests that white blood cell count (WBC) is associated with infection in patients who undergo TS. We sought to find whether there exist key differences in laboratory and clinical parameters that can assist the diagnosis of infection after TS. Methods: We evaluated all consecutive trauma patients who had undergone TS at a Level 1 trauma center from 2005 to 2011 for the development of infection. To do this, we compared the values of demographic, laboratory, and clinical variables of …