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Low Hydrophobic Mismatch Scores Calculated For Hla-A/B/Dr/Dq Loci Improve Kidney Allograft Survival, Dulat Bekbolsynov, Beata Mierzejewska, Jadwiga Borucka, Robert S. Liwski, Anna L. Greenshields, Joshua Breidenbach, Bradley Gehring, Shravan Leonard-Murali, Sadik A. Khuder, Michael Rees, Robert C. Green Ii, Stanislaw M. Stepkowski
Low Hydrophobic Mismatch Scores Calculated For Hla-A/B/Dr/Dq Loci Improve Kidney Allograft Survival, Dulat Bekbolsynov, Beata Mierzejewska, Jadwiga Borucka, Robert S. Liwski, Anna L. Greenshields, Joshua Breidenbach, Bradley Gehring, Shravan Leonard-Murali, Sadik A. Khuder, Michael Rees, Robert C. Green Ii, Stanislaw M. Stepkowski
Computer Science Faculty Publications
We evaluated the impact of human leukocyte antigen (HLA) disparity (immunogenicity; IM) on long-term kidney allograft survival. The IM was quantified based on physicochemical properties of the polymorphic linear donor/recipient HLA amino acids (the Cambridge algorithm) as a hydrophobic, electrostatic, amino acid mismatch scores (HMS\AMS\EMS) or eplet mismatch (EpMM) load. High-resolution HLA-A/B/DRB1/DQB1 types were imputed to calculate HMS for primary/re-transplant recipients of deceased donor transplants. The multiple Cox regression showed the association of HMS with graft survival and other confounders. The HMS integer 0-10 scale showed the most survival benefit between HMS 0 and 3. The Kaplan-Meier analysis showed that: …