Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
A Nonlinear Ode Model Of Tumor Growth And Effect Of Immunotherapy And Chemotherapy Treatment In Colorectal Cancer, Hannah P. Savage
A Nonlinear Ode Model Of Tumor Growth And Effect Of Immunotherapy And Chemotherapy Treatment In Colorectal Cancer, Hannah P. Savage
HMC Senior Theses
Colorectal cancer will kill approximately 50,000 people in the United States this year. Current treatment options, including surgery, chemotherapy, and radiation, are often able to force the cancer into remission, but better treatments are needed to help those who don't respond to current treatments. A new and promising treatment option, monoclonal-antibody therapy, has the potential to help reduce the deaths caused by colorectal cancer, but most monoclonal-antibody drugs are currently still in trial phases, and the variations in the dosing schedule of those currently approved for use have not been heavily explored. We have modified a nonlinear ODE tumor/treatment model …
Analysis Of The Effect Of Various Ligands On The Hydrolysis Of Ruthenium (Iii) Complexes And Interpretation Of Kinetics Of Hydrolysis Profiles By Uv-Visible Spectrophotometry, Sudheer Koneru
Master's Theses and Doctoral Dissertations
Cancer is one of the major causes of death in the world. Discovery of platinum metal-based drugs like cisplatin and carboplatin have proved to be successful in cancer treatment. Due to subsequent development of resistance, side effects, and fewer toxic effects of these drugs, the usage of these drugs has been limited. Novel drugs were being synthesized utilizing the transition metals like ruthenium, osmium, and copper.
In this research, ruthenium metal complexes of the formula HL[RuCl4L2] (where L= ligand) were synthesized. These ruthenium-based drugs exist in prodrug forms which are activated into antitumor drugs by means of hydrolysis, redox reactions, …