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Design And Synthesis Of Tlr2 And Tlr6 Heterodimer Ligands, A Triply Functionalized Α-Galcer Derivative For Identifying Proteins Involved In Glycolipid Trafficking, And The Disaccharide Of Staphylococcus Aureus Cp8 Towards A Self-Adjuvanting Vaccine, Sara Mayeth Mata
Theses and Dissertations
Toll like receptors (TLRs) are found on B cells, macrophages, monocytes, and dendritic cells, and these cells belong to the innate immune system that recognizes antigens and induces multiple cell responses through the release of cytokines. TLR1, TLR2 and TLR6 function as heterodimers, either as TLR1/TLR2 or TLR2/TLR6 to recognize lipopeptides. TLR1/2 dimer activation releases inflammatory cytokines, while TLR2/TLR6 dimer activation releases immunomodulatory cytokines. Based on the size of the binding pocket between TLR2 and TLR6, it was hypothesized that lipopeptides, such as FSL1, could be simplified while keeping overall activity. FSL1 is a lipopeptide first isolated from Mycoplasma salivarum …
From General Chemistry To Anatomy And Physiology: Revalidating And Adapting Assessments And Models, Victoria Fisher
From General Chemistry To Anatomy And Physiology: Revalidating And Adapting Assessments And Models, Victoria Fisher
Theses and Dissertations
The 1980s saw an increasing demand for education standards that would create a scientifically literate society. In response, the American Association for the Advancement of Science (AAAS) published a report that outlined four themes that are characteristic of a scientifically literate individual: systems, models, constancy and change, and scale (1). In 1993, the AAAS published the Benchmarks for Science Literacy which outlined common scientific skills that a student should be able to demonstrate by grades 2, 5, 8, and 12 (2). Beyond the AAAS scale was not included in national science educational standards until 2012 when the National Research Council …
Interfacial Ligand Dynamics And Chemistry On Highly Curved Nanoparticle Surfaces: A Plasmon-Enhanced Spectroscopic Study, Esteban Villarreal
Interfacial Ligand Dynamics And Chemistry On Highly Curved Nanoparticle Surfaces: A Plasmon-Enhanced Spectroscopic Study, Esteban Villarreal
Theses and Dissertations
The dynamic interactions between capping ligands and nanoparticle surfaces play a critical role in guiding shape-controlled nanocrystalline growth, imparting unique physical and chemical properties to the nanoparticles. It has been well established that nanoparticles within the size regime of sub 5 nm possess unique heterogeneous catalytic properties, while sub wavelength metallic nanoparticles exhibit tunable plasmonic activity, when these properties are integrated into a single nanoparticle, it presents a significant opportunity to monitor, in real time, the molecular transformations associated with interfacial interactions at the nanoparticle surface. Using plasmon-enhanced Raman scattering as an ultrasensitive spectroscopic tool combining molecular fingerprinting with time …