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Comparative Analysis Of Parametric, Nonparametric And Permutation Methods For Differential Expression, Rahul Patil

Theses

DNA microarrays permit us to study the expression of thousands of genes simultaneously. They are now used in many different contexts to compare mRNA levels between two or more samples of cells. Microarray experiments typically give us expression measurements on a large number of genes. Increasing popularity of microarray technology has resulted in a number of tests being proposed to detect differentials expression.

The purpose of study is to compare the parametric, non parametric and permutation tests when applied to microarray data for differential expression analysis. t test (parametric), Mann Whitney test (nonparametric) and Significance of analysis (permutation ) test …