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Effects Of Novel Synthetic Nucleosides As Anti-Tumor Agents On Human Acute Promyelocytic Leukemia Cell Line (Hl-60), Salma Awad Merghani Mahmoud
Effects Of Novel Synthetic Nucleosides As Anti-Tumor Agents On Human Acute Promyelocytic Leukemia Cell Line (Hl-60), Salma Awad Merghani Mahmoud
Theses
Nucleosides and their analogs are considered a clinically proven class of therapeutic agents possessing anticancer and antiviral activity. Several trifluoromethyl-substituted pyrazole N-nucleosides (coded NIA, NIIA and NIIA) and their nucleobases were synthesized and tested for the ability to induce apoptosis in acute human promyelocytic cell line (HL-60). The growth and proliferation of HL-60 was more effectively inhibited by NIA, NIIA and their nucleobases compared to NIIIA and its nucleobase. In addition, DNA fragmentation was detected in a concentration-dependent manner as a result of nucleosides treatment. A caspase-3-dependent apoptosis was observed based on the Western blot analysis of poly-ADP-ribose polymerase (PARP) …