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Increasing Solubility Of Active Pharmaceutical Ingredients In Topical Creams Using Soluplus®, Roni Balzam
Increasing Solubility Of Active Pharmaceutical Ingredients In Topical Creams Using Soluplus®, Roni Balzam
MSU Graduate Theses
More than 40% of new chemicals developed in the pharmaceutical industry have poor solubility in aqueous solutions. Active Pharmaceutical ingredients (API) cannot reach their molecular targets in the body if the drug remains undissolved in the gastrointestinal system. One way to approach this problem is by using solubilizing agents. One such agent is a thermo-responsive, tri-block co-polymer which is marketed as “Soluplus®" (SP) by BASF Corporation. A part of this project is to thoroughly characterize various phase properties of SP such as cloud points and gel points temperatures. In current application, SP was incorporated into the creams formulations as an …