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Towards The Discovery Of Oligonucleotide Cross-Linking Agents, Bhaskar Halami
Towards The Discovery Of Oligonucleotide Cross-Linking Agents, Bhaskar Halami
Dissertations, Master's Theses and Master's Reports
Oligonucleotide cross-linking agents are expected to become a new class of antisense drugs. They function by first hybridizing with a complementary mRNA and then form a covalent bond to permanently link the mRNA to the oligonucleotide agent. Because of covalent cross-linking, this new class of antisense drugs are expected to have much higher potency than existing ones.
Some oligonucleotide cross-linking agents have appeared in the literature, but they have various drawbacks, which include slow cross-linking rate and reversible cross-linking. To address these problems, we designed a series of new cross-linking oligonucleotides with a range of different reactivities. These oligonucleotides were …