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Novel Ruthenium Complexes As Photodynamic Therapeutic Agents, Sareen Kumar Kushangari

All Capstone Projects

This project reviews the literature of novel ruthenium c complexes in photodynamic drug therapy. (Abstract by OPUS staff)

Synthesis Of A Folate Receptor Mass Spectrometry Probe, Audrea Rhymes

All Capstone Projects

Drug delivery is one of the most important concepts for cancer patients because it is oftentimes very difficult or nearly impossible to exclusively target cancerous cells. In this study, the aim was to target receptors on cancerous cells, specifically the Folate Receptor (FR). This specific receptor was targeted because it has been proven to enhance intracellular delivery being that folic acid is an integral species in normal cell function and also that cancerous cells tend to exhibit an abnormally high concentration of Folic Acid on cell surfaces.

The application of dyes is a very common practice used to link folic …

Encapsulated Antibiotic Nanoparticles For Cranial Transplantation, Adusumilli Naga Anusha

All Capstone Projects

The purpose of this research is to develop a unique nanoparticulate system that is capable of delivering antibiotics in a locally applied and extended-release manner for patients receiving cranial replacement implants and bone grafting. This study involves three major components: first, encapsulate both hydrophobic antibiotics (chloramphenicol and rifampicine) and hydrophilic antibiotics (vancomycine and acyclovir) into nanoparticles. Second, incorporate antibiotic nanoparticles in a polymeric coating material (nitrocellulose plus 7.0% (w/v) polyvinylpyrrolidone) with a volatile carrier solvent (ethyl acetate or ethanol). Third, directly apply the resulting product from component 1 and 2 to polymethyl methacrylate (PMMA) cranial implants and hydroxylapatite (HA) bone …

Nanoencapsulated Drug-Carrying System For Photodynamic Antimicrobial Chemotherapy (Pact), Gopala Krishna Murthy Kalapala

All Capstone Projects

The purpose of this study is to develop nanoparticulate drug-carrying systems that are capable of directly delivering photodynamic antimicrobial agents to treat patients with chronic wounds. Chronic wounds are considered as a pandemic health problem. Approximately 1% to 2% of the population in developing countries has experienced a chronic wound during their lifetime. In the United State States, according to the American Academy of Dermatology, the expense of treating chronic wounds constitutes over half of the total cost for all skin diseases, which exceeds $10 billion annually. For the last decade extensive basic science and clinical research in chronic wounds …

Detection Of Folate Receptor From Fr+ Cancer Cells, Darpan Patel

All Capstone Projects

The aim was to detect cancer cells by using folate–PEG-Biotin probe with fluorescently labeled streptavidin for targeted drug delivery of anti-cancer drugs and diagnose cancer cells. Folate-PEG-Biotin (synthesized by Dr. Henne and Mr.Rohan Patel) was purified by HighPeformanceLiquidChromatography (HPLC) analysis and with the help of Liquid Chromatography/Mass Spectrometry (LC/MS) its identity was confirmed. Folate is a basic composition of cell metabolism in both synthesis of DNA and proteins. Growing cancer cells require high level of folic acid. Folate Receptor-α (FR-α) is a membrane bound protein having high affinity for folic acid and serves to transport of folate into cells. Poly …

Evaluation And In Vitro Studies Of Folate-Peg-Biotin, Kuldeep Reddy Vanga

All Capstone Projects

Folate receptor is a membrane bound protein which is highly expressed by cancer cells and macrophages. Folic acid is required for the normal growth of cells and it has been found that rapidly growing cancer cells require high levels of folic acid. Folic acid binds to folate receptors and through receptor mediated transport folate enters cells. This property has been used to synthesize a probe using folate as ligand through polyethylene glycol-Biotin linker. This can be used to attach a drug which is ultimately delivered at the site of infectious cells. The study involved here was to determine how folate …