Digital Commons Network^™

Dental Hygienists' Cognitive Process In Periodontal Soft Tissue Charting, Kelsey M. Schwei

Theses and Dissertations

Introduction: Dental hygienists have not had the opportunity to be involved in the design and development of the periodontal soft tissue charts and the surrounding interface features that are used while examining dental patients in daily practice. In some cases, dentists are able to give their opinions, wants, and needs into the development of the health information systems that they use on a daily basis, but too often, the dental hygienist is forgotten about and no input is ever given to the developers from the dental hygienists. This project considers the impact of well-designed interfaces on effectiveness and workflow particularly …

Warranty Period And Product Price Optimization For Remanufactured Products, Yuxi Liu

Theses and Dissertations

This study considers a remanufactured electrical product under a tiered warranty policy. Warranty is key in ensuring a good manufacturer—consumer relationship. Manufacturers hope to minimize warranty costs while consumers believe that good warranty promises better product quality and reliability. This Thesis presents an optimal warranty period from the perspective of a manufacturer to maximize the total expected profits, while ensuring sustained consumer relation. We use real data from a local company with a global supply chain to provide a numerical example.

Arylboronates As H2o2 Or Photo-Inducible Dna Cross-Linking Agents: Design, Synthesis, Mechanism, And Anticancer Activity, Yibin Wang

Theses and Dissertations

Interest in the development of cancer therapies with improved selectivity and reduced host toxicity has been growing. In this thesis, we designed and synthesized a series of novel non-toxic arylboronic ester and biarylboronic ester derivatives that can be activated by hydrogen peroxide (H2O2) to induce DNA interstrand cross-link formation. The mechanism of DNA cross-linking induced by these arylboronates involves generation of phenol intermediates 1 followed by departure of leaving group (L) leading to quinone methides (QMs) 2, which directly cross-link DNA via alkylation. The QM formation is the rate-determining step for DNA cross-linking. The activity and selectivity of these compounds …

Assessing The Effects Of Riverbank Inducement On A Shallow Aquifer In Southeastern Wisconsin, Laura Rachel Fields-Sommers

Theses and Dissertations

The state of Wisconsin is heavily reliant upon groundwater resources. In order to induce river water, implementation of shallow wells with close proximity to river systems is being used as a method to augment groundwater supplies in portions of southeastern Wisconsin. However, river bank wells (RBI) are vulnerable to contamination due to their close interaction with the surface water. The vulnerability increases when induced surface waters contain municipally treated waste water. The objective of this study was to determine the current and potential influences of riverbank inducement, recharge mechanisms of the well field, and to discriminate the sources of sodium …

Transport Mechanisms For Human Fecal Indicator Bacteria In An Urban Stormwater Basin In Southeastern Wisconsin, Chelsea M. Corson

Theses and Dissertations

Discharge of stormwater runoff to receiving waters is a known source of human pathogens; however the primary mechanisms by which these pathogens enter the stormwater system have yet to be quantified. This study builds upon and utilizes prior research findings in an attempt to explain the influence of the age of the pipes within stormwater and sanitary conveyance systems, rainfall and hydrogeological characteristics, and select infrastructure variables that contribute to the observed contamination of an urban stormwater basin in Southeastern Wisconsin.

Over the course of approximately two years from 2012 to 2014, a total of 260 samples from 22 stormwater …

The Mixing Of A River Into Coastal Waters At Two Beaches: Environmental Factors, E. Coli Contributions And Applications For Predictive Models, Adrian Jordan Koski

Theses and Dissertations

Beach closures and public health protection are confounded by analytical procedures that result in delays in notification of adverse water quality conditions and the lack of affordable analytical methods to identify pollutant sources. Attempts have been made to develop predictive frameworks using ancillary hydrometeorological data to statistically anticipate deteriorated water quality. Many urban coastal beaches are impacted by river runoff. In Kenosha Wisconsin, beach sanitary survey data from two beaches adjacent to the mouth of the Pike River were examined to ascertain whether simple river-lake mixing models identified river influence on coastal water quality and improved predictions of beach advisories. …

Iodine-131: Measurement And Application Of A Novel Tracer In Lake Michigan, Michael Patrick Montenero

Theses and Dissertations

Iodine-131 is a short-lived (half-life=8.0233 days), gamma emitting, radiopharmaceutical that, when excreted by patients, enters aquatic systems via sewage effluent discharged from water reclamation facilities (WRFs). Here, I report on 131I activities in the nearshore of southwest Lake Michigan in the vicinity of Milwaukee, Wisconsin. This is the first report on 131I activity in any of the Great Lakes of North America.

The flux of 131I from Milwaukee’s two WRFs was monitored from July 2013 to December 2014. Mean discharge of 131I from the Jones Island WRF was (0.664 ± 0.012)×108 Bq d-1 (mean effluent 131I activity: ~0.25 Bq L-1; …

The Identification And Quantification Of Sewage Contamination In The Milwaukee Estuary, Hayley Templar

Theses and Dissertations

Sewage contamination from failing infrastructure and sewer overflows is a major environmental and human health concern in waterways, especially in urban communities bordering the Great Lakes such as Milwaukee, Wisconsin. Culture-based fecal indicator bacteria, such as Escherichia coli, enterococci, and fecal coliforms are traditionally used to indicate the presence of a human health risk due to fecal contamination. These indicators, however, fail to distinguish between sources of fecal contamination (human vs. non-human). Two human-specific fecal indicators, human Bacteroides and human Lachnospiraceae, were used to identify and quantify sewage contamination in the Milwaukee estuary, which discharges to Lake Michigan, as well …

Quality Enhancement Of 3d Models Reconstructed By Rgb-D Camera Systems, Chuanbo Wang

Theses and Dissertations

Low-cost RGB-D cameras like Microsoft's Kinect capture RGB data for each vertex

while reconstructing 3D models from objects with obvious drawbacks of poor mesh

and texture qualities due to their hardware limitations. In this thesis we propose a combined method that enhances geometrically and chromatically 3D models reconstructed by RGB-D camera systems. Our approach utilizes Butterfly Subdivision and Surface Fitting techniques to generate smoother triangle surface meshes, where sharp features can be well preserved or minimized by different Surface Fitting algorithms. Additionally the global contrast of mesh textures is enhanced by using a modified Histogram Equalization algorithm, in which the …

Theoretical Investigation Of Interactions And Relaxation In Biological Macromolecules, Koki Yokoi

Theses and Dissertations

One of the major challenges posed to our quantitative understanding of structure, dynamics, and function of biological macromolecules has been the high level of complexity of biological structures. In the present work, we studied interactions between G protein-coupled receptors (GPCRs), and also introduced a theoretical model of relaxation in complex systems, in order to help understand interactions and relaxation in biological macromolecules.

GPCRs are the largest and most diverse family of membrane receptors that play key roles in mediating signal transduction between outside and inside of a cell. Oligomerization of GPCRs and its possible role in function and signaling currently …

Monitoring And Modeling The Hydrological Performance Of Extensive Green Roof Systems, Joseph Seidl

Theses and Dissertations

Urban stormwater runoff causes many problems for watersheds located within large metropolitan areas, including such detrimental effects as flooding, erosion, pollution, and the increased risk of combined sewerage overflows. Increased amounts of impervious areas resulting from urban sprawl have also been shown to escalate stormwater flows, which exacerbates water management issues in these metropolitan areas. Water resource engineers have progressively turned toward green infrastructure to solve stormwater problems, and green roof systems represent one type of this green infrastructure. As of current, however, green roof systems are largely underused in as an effective stormwater management tool.

The major factor limiting …

Hydrodynamic Modeling Of The Green Bay Of Lake Michigan Using The Environmental Fluid Dynamics Code, Paula Estefania Cedillo

Theses and Dissertations

In this project we created a hydrodynamic model of the Lower Green Bay of Lake Michigan in Wisconsin, United States using the Visual Environmental Fluid Dynamics Code (EFDC). The model includes four tributary rivers to Lower Green Bay as well as the open boundary flow conditions at Chambers Island. This case study is used to: 1) compare the results obtained with a previous study of Lower Green Bay to validate the creation of the model 2) examine the hydrodynamics of the bay, and 3) create a framework for future studies at Lower Green Bay. The Geographic Information used to build …

Time-Resolved, Near Atomic Resolution Structural Studies At The Free Electron Laser, Jason James Tenboer

Theses and Dissertations

Time-resolved serial femtosecond crystallography (TR-SFX) employs X-ray free electron lasers (XFELs) to provide X-ray pulses of femtosecond (fs) duration with 1012 photons per pulse. These XFELs are more than a billion times more brilliant than 3rd generation synchrotron X-ray sources. For structure determination, protein crystals on the micrometer length scale (microcrystals) are injected into the X-ray beam and the resulting diffraction patterns are recorded on fast-readout pixel detectors. Although these intense pulses deposit enough energy to ultimately destroy the protein, the processes that lead to diffraction occur before the crystal is destroyed. This so-called diffraction-before-destruction principle overcomes radiation damage, which …

Addressing Potential Risks And Challenges Of Co2 Geologic Sequestration, Ethan Guyant

Theses and Dissertations

Carbon Capture and Geologic Storage is a viable technology to reduce the concentration of CO2 emitted to the atmosphere, however there remains challenges and risks associated with implementing this technology. One of the challenges, and the focus of Chapter 2, is maintaining the injectivity of the reservoir throughout the entire injection period of a project. While potential risks include the pressurization of the reservoir and the leakage of CO2 and/or brine out of the storage reservoir which is the focus of Chapter 3. A consequence of injecting dry-supercritical CO2 is that it results in salt precipitation in the near well …

Field And Laboratory Study Of The Flàajökull Glacier, Iceland, William Russell Jacobson, Jr.

Theses and Dissertations

The increased surface melting of the outlet glaciers of the Vatnajökull Ice Cap has a profound affect on the dynamics of the ice-bed couple and landform genesis. Soft-bedded glaciers are largely inaccessible, which creates a problem. One challenge is to understand the complex interactions of the glacier bed and its resultant depositional and deformational landform systems. This study investigates an outlet glacier from the Vatnajökull Ice Cap, described herein as the Fláajökull glacier system. To circumvent some of these problems, three separate projects were conducted in this dissertation: (1) magnetic fabric study of effective pressure (difference between the ice-overburden pressure …

Relative Divergence, Subgroup Distortion, And Geodesic Divergence, Hung Cong Tran

Theses and Dissertations

In the first part of this dissertation, we generalize the concept of divergence of finitely generated groups by introducing the upper and lower relative divergence of a finitely generated group with respect to a subgroup. Upper relative divergence generalizes Gersten's notion of divergence, and lower relative divergence generalizes a definition of Cooper-Mihalik. While the lower divergence of Cooper-Mihalik can only be linear or exponential, relative lower divergence can be any polynomial or exponential function. In this dissertation, we examine the relative divergence (both upper and lower) of a group with respect to a normal subgroup or a cyclic subgroup. We …

Part I. The Development Of Non-Secosteroidal Vitamin D Receptor Modulators Part Ii. The Development Of A Universal Gtp-Ase Assay, Kelly Ann Teske

Theses and Dissertations

The vitamin D receptor is a nuclear hormone receptor that regulates cell proliferation, cell differentiation, calcium homeostasis and immunomodulation. The receptor is activated by the vitamin D metabolite, 1,25-dihydroxyvitamin D3, which induces a cascade of events including the recruitment of coactivators that activate transcription of specific VDR target genes. Thousands of VDR agonists have been synthesized based on the secosteroid scaffold of 1,25-dihydroxyvitamin D3. However, most of these ligands are metabolically unstable, have sub-optimal drug-like properties, and induce hypercalcemia in vivo. The limited numbers of VDR antagonists reported bear the same secosteroid scaffold and thus exhibit similar problems encountered by …

The Great Lakes' Regional Climate Regimes, Noriyuki Sugiyama

Theses and Dissertations

For the last couple of decades, the Great Lakes have undergone rapid surface warming. In particular, the magnitude of the summer surface-warming trends of the Great Lakes have been much greater than those of surrounding land (Austin and Colman, 2007). Among the Great Lakes, the deepest Lake Superior exhibited the strongest warming trend in its annual, as well as summer surface water temperature. We find that many aspects of this behavior can be explained in terms of the tendency of deep lakes to exhibit multiple regimes characterized, under the same seasonally varying forcing, by the warmer and colder seasonal cycles …

A Machine-Aided Approach To Generating Grammar Rules From Japanese Source Text For Use In Hybrid And Rule-Based Machine Translation Systems, Sean Michael Jones

Theses and Dissertations

Many automatic machine translation systems available today use a hybrid of pure statistical translation and rule-based grammatical translations. This is largely due to the shortcomings of each individual approach, requiring a large amount of time for linguistics experts to hand-code grammar rules for a rule-based system and requiring large amounts of source text to generate accurate statistical models. By automating a portion of the rule generation process, the creation of grammar rules could be made to be faster, more efficient and less costly. By doing statistical analysis on a bilingual corpus, common grammar rules can be inferred and exported to …

Making Mathematics Memorable, Meaningful, And Fun: Activities To Enhance Precalculus, Nat White

Theses and Dissertations

To master material, students need to make it their own. As teachers, we should structure their interactions with mathematics in ways that are memorable, meaningful, and fun. One way to do this is to provide activities that stretch beyond the textbook and lead students to think and talk to one another about mathematics. This thesis contains a set of activities designed to enhance a precalculus course, along with solutions and feedback on each activity.

Multi-Level Optimal Design Using Game Theory With Model Updating By Low Discrepancy Sampling, Yanchen Xu

Theses and Dissertations

The Design of Experiment (DOE) based response surface methodology (RSM) is a commonly used technique for solving optimization problems. The traditional DOE method has some shortcomings when used to update the RSM model. This thesis aims to develop a new DOE technique to solve the model updating problems in design optimization. Toward this end, a new DOE based RSM method is proposed to solve this problem by using low-discrepancy sequence method to generate the additional data points needed to update the model to replace the traditional factor and level based DOE method.

Tested on a couple of numerical example problems, …

A Systems Approach To Point Source Indication Of Metformin Found In Local Water Systems – The Case Of Milwaukee County, Mohamed Salem Baitelmal

Theses and Dissertations

Pharmaceutical pollutants are present in traceable concentrations in Milwaukee County water system and Lake Michigan. The actual point sources and nature of entry into the water system is difficult to determine with certainty. Pharmaceuticals have been found to persist at the South Shore Wastewater Treatment Facility (SSWTF) in Milwaukee, Wisconsin. The highest concentration was found to be for the pharmaceutical drug metformin. Metformin is a first line drug for the treatment of type 2 diabetes mellitus.

The broad goal of this exploratory study; the first of its kind, is to correlate trace concentrations of drugs to the point sources. Particularly, …

Water Withdrawal And Consumption Reduction Analysis For Electrical Energy Generation System, Narjes Nouri

Theses and Dissertations

There is an increasing concern over shrinking water resources. Water use in the energy sector primarily occurs in electricity generation. Anticipating scarcer supplies, the value of water is undoubtedly on the rise and design, implementation, and utilization of water saving mechanisms in energy generation systems are becoming inevitable. Most power plants generate power by boiling water to produce steam to spin electricity-generating turbines. Large quantities of water are often used to cool the steam in these plants. As a consequence, most fossil-based power plants in addition to consuming water, impact the water resources by raising the temperature of water withdrawn …

Investigation Of Electrolyte Wetting In Lithium Ion Batteries: Effects Of Electrode Pore Structures And Solution, Yangping Sheng

Theses and Dissertations

Beside natural source energy carriers such as petroleum, coal and natural gas, the lithium ion battery is a promising man-made energy carrier for the future. This is a similar process evolved from horse-powered era to engine driven age. There are still a lot of challenges ahead like low energy density, low rate performance, aging problems, high cost and safety etc.

In lithium ion batteries, investigation about manufacturing process is as important as the development of material. The manufacturing of lithium ion battery, including production process (slurry making, coating, drying etc.), and post-production (slitting, calendering etc.) is also complicated and critical …

Porphyrin As A Spectroscopic Probe Of Net Electric Fields In Heme Proteins, Hannah Elizabeth Wagie

Theses and Dissertations

Heme proteins have diverse functions as well as varied structures but share the same organic, conjugated cofactor. Similarly varied approaches have been taken to deduce how heme can take on different roles based on its protein environment. A unique approach is to view the protein matrix as a constellation of point charges that generates a defined, reproducible, net internal electric field that has influence over the electronic properties of the heme cofactor. This work considers how porphyrins, the basic chromophore building block of heme, can be used as a native spectroscopic sensor of internal electric field at the active site …

Effects Of Visualization On Algorithm Comprehension, Matthew Mulvey

Theses and Dissertations

Computer science students are expected to learn and apply a variety of core algorithms which are an essential part of the field. Any one of these algorithms by itself is not necessarily extremely complex, but remembering the large variety of algorithms and the differences between them is challenging. To address this challenge, we present a novel algorithm visualization tool designed to enhance students understanding of Dijkstra’s algorithm by allowing them to discover the rules of the algorithm for themselves. It is hoped that a deeper understanding of the algorithm will help students correctly select, adapt and apply the appropriate algorithm …

Neurobehavioral And Gene Expression Effects Of Early Embryonic Methylmercury Exposure In Yellow Perch (Perca Flavescens) And Zebrafish (Danio Rerio) Larvae, Francisco Xavier Mora Zamorano

Theses and Dissertations

Methylmercury (MeHg) is a pervasive and persistent neurotoxic environmental pollutant known to affect the behavior of fish, birds and mammals. The present study addresses the neurobehavioral and gene expression effects of MeHg in yellow perch (Perca flavescens) and zebrafish (Danio rerio) embryos. The rationale for this study originated from an interest to understand the behavioral and molecular phenotypes of environmental MeHg exposure in the yellow perch, an ecologically and economically relevant species of the North American Great Lakes region. Both MeHg and the yellow perch coexist in a common ecosystem: the North American Great Lakes. However, the effects of this …

Enantiospecific Stereospecific Strategy For The Total Synthesis Of Sarpagine And Macroline Related Oxindole Alkaloids: First Total Synthesis Of Affinisine Oxindole, Isoalstonisine, Alstofoline, Macrogentine, N(1)-Demethylalstonisine, Alstonoxine A And Second Generation Synthesis Of Alstonisine, German Oscar Fonseca Cabrera

Theses and Dissertations

The (7R)-sarpagine/macroline related oxindole alkaloids (-)-isoalstonisine (27) and (-)-macrogentine (31) together with the (7S)-sarpagine/macroline related oxindole alkaloids (-)-affinisine oxindole (24), (-)-alstonoxine A (19), (+)-alstonisine (8, second generation total synthesis), (+)-Na-demethylalstonisine (17) and (+)-alstofoline (18) were concisely synthesized during these studies.

These oxindole alkaloids were isolated from plants of the genus Alstonia which is characterized by the preponderance of sarpagine/macroline-type indole and oxindole alkaloids. Plants that belong to this genus are mainly distributed over tropical regions of Central America, Africa, and Asia where they are used locally in traditional medicine, for example, in the treatment of malaria and dysentery. The main …

Heun Polynomials In The Construction Of Vector Valued Slepian Functions On A Spherical Cap, Thomas Anthony Ventimiglia

Theses and Dissertations

I summarize the existing work on the problem of finding vector valued Slepian functions on the unit sphere: separable vector fields whose energy is concentrated within a compact region; in this case, a spherical cap. The radial and tangential components are independent for an appropriate choice of basis, and for each component the problem is recast as that of finding real eigenfunctions of an integral operator. There exist Sturm-Liouville differential operators that commute with these integral operators and hence share their eigenfunctions. Therefore, the radial and tangential eigenfunctions are solutions to second order linear ODEs. After introducing the Heun differential …

Sedimentology And Stratigraphy Of High-Latitude, Glacigenic Deposits From The Late Paleozoic Ice Age In The Tepuel-Genoa Basin, Patagonia, Argentina, Sarah Rose Survis

Theses and Dissertations

The Late Paleozoic Ice Age (LPIA) was the longest lived ice age of the Phanerozoic lasting ~87 million years. During this time multiple, small ice sheets advanced and retreated with alternating glacial and nonglacial intervals across Gondwana. Controversy still remains over the size, timing, and number of ice sheets because the traditional view of Gondwana during this time is of a single, large ice sheet that waxed and waned across the supercontinent. Furthermore, high-latitude glacially-influenced basins during the Carboniferous have received limited attention, underscoring the poor understanding of glacial to non-glacial transitions. The Tepuel Basin in Patagonia, Argentina, was located …