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Synthesis Of Small Molecule Modulators Of Non-Traditional Drug Targets, Jamie Nunziata
Synthesis Of Small Molecule Modulators Of Non-Traditional Drug Targets, Jamie Nunziata
USF Tampa Graduate Theses and Dissertations
This work details the effort toward structure-activity-relationship (SAR) studies and synthesis of the small molecule modulators of two non-traditional drug targets. The first part of this manuscript (chapters 1–2) will discuss the collaborative work and synthesis of an inhibitor of Slingshot Homology 1 (SSH1) with the potential therapeutic application toward Alzheimer’s Disease (AD) treatment. The second part (chapters 3–6) will discuss the synthetic efforts toward modulation of a protein target known as STING, or stimulator of interferon genes, with the therapeutic application toward autoimmune disease or anti-tumor activity.
AD is a progressive and degenerative illness that holds the title of …
The Activity And Structure Of Cu2+-Biomolecules In Disease And Disease Treatment, Darrell Cole Cerrato
The Activity And Structure Of Cu2+-Biomolecules In Disease And Disease Treatment, Darrell Cole Cerrato
USF Tampa Graduate Theses and Dissertations
Despite its relatively low concentration in the human body, copper is an essential transition metal ion. Under normal circumstances, it is a well-regulated trace element that is introduced via diet or environment depending on the organism. Its strong reactivity and binding to some biologically essential chemicals can be detrimental to the host organism. Herein the oxidative chemistry of copper and its possible prevention in humans and agricultural organisms is discussed, as well as the potential avenues as metal-targeting disease treatment via novel-peptide and peptoid products.
In the first study, copper is implicated in the progression and onset of Alzheimer’s disease. …