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A Perspective On How To Improve Undergraduate Research Education In The Physical Sciences At Usc, Michael Caleb Bagley

Senior Theses

My years at the University of South Carolina have been some of the most challenging and edifying periods of my life. I have been blessed by having a great professional and chemistry mentor in Dr. John L. Ferry who has helped me engage in scientific research in a meaningful way. As I watched other chemistry students, in particular, struggle with understanding what research really was and even how to understand the results and methodologies of it I felt that this was a huge issue that could be rather simply fixed. I have been privileged to apply for and receive a …

A Study Of Anti-Muon-Neutrino Induced Resonance Production In Nomad Three-Track Topology, Edward Dunton

Senior Theses

In this study we are attempting to measure the sensitivity of our methods to anti-muon neutrino induced resonance interactions in the 3-track topology of the NOMAD experiment. We will use a set of Monte Carlo data meant to resemble the NOMAD outputs but with true event type known and then proceed by using a system of single-variable cuts and multivariable analysis through a multilayer perception neural network to distinguish events from these interactions and events from other neutrino or non-neutrino interactions. We will then produce a measurement of the sensitivity to these interactions and determine whether or not proceeding with …

Google Street View As A Medium For Social Gaming, Steven Dao, Tien Ho, Austin Pahl

Senior Theses

safehouse is a head-to-head Street View game drawing inspiration from GeoGuessr and Pursued. It will be available to play in a web browser on our website, http://thesafe.house. The game aims to let players discover new places in the world in a uniquely competitive way. At the start of each match, players will find themselves in a random Street View location in an unknown area, pitted against each other with one of two tasks: the pursued must locate a safe house somewhere in the city, and the pursuer must catch the pursued. Each player will have to rely on quick …

Addressing The Issue Of Climate Change Denial, Katherine M. Kacsur

Senior Theses

Climate change is real. It is not a debate, and it is not a theory. It is not a part of the “liberal agenda”, and is not a ploy to raise taxes or expand government. Climate change is real, and it is happening right now. Every time someone starts their car, turns on a light, or cranks up the air conditioning, carbon dioxide is added to the atmosphere. Because of its power to capture heat in the atmosphere, carbon dioxide has allowed for more and more warming around the globe. As energy consumption only continues to increase, the effects of …

Topics In Group Testing With Multiple Infections, Peijie Hou

Theses and Dissertations

Group testing, dating back to the early 1940s, was first proposed to screen for syphilis among US inductees during World War II (Dorfman, 1943). Since then, the benefits of reducing testing costs by employing group testing have been demonstrated in many areas, such as drug discovery, genetics, and infectious disease testing. Traditionally, statistical research in group testing has largely been motivated by applications involving a single infection. With the recent development of multiplex assays that can diagnose multiple infections simultaneously, generalizing the existing group testing literature to incorporate multiple infections is a natural and necessary next step. This dissertation consists …

Characterization Of Sufs And Sufe Of Suf Pathway For Fe-S Cluster Assembly In Escherichia Coli, Guangchao Dong

Theses and Dissertations

Fe-S clusters are one major type of the sulfur-containing cofactors, which conduct essential functions in organisms. The Suf pathway is one of the three main pathways for the biosynthesis of Fe-S clusters. In E. coli, the Suf pathway is utilized under iron limitation and oxidative stress. This ability is important for pathogens to survive. Also, the Suf pathway is found to be exclusive in bacteria, so it is a good target for novel antibiotic design. SufS is a cysteine desulfurase in the Suf pathway to extract sulfur from L-cysteine. It needs the enhancement of SufE. To better understand the catalytic …

On The Existence Of Non-Free Totally Reflexive Modules, J. Cameron Atkins

Theses and Dissertations

For a standard graded Cohen-Macaulay ring R, if the quotient R/(x) admits nonfree totally reflexive modules, where x is a system of parameters consisting of elements of degree one, then so does the ring R. A non-constructive proof of this statement was given in [16]. We give an explicit construction of the totally reflexive modules over R obtained from those over R/(x).

We consider the question of which Stanley-Reisner rings of graphs admit nonfree totally reflexive modules and discuss some examples. For an Artinian local ring (R,m) with m3 = 0 and containing the complex numbers, we describe an explicit …

Bird's Eye View: Cooperative Exploration By Ugv And Uav, Shannon Hood

Theses and Dissertations

This paper proposes a solution to the problem of cooperative exploration using an Unmanned Ground Vehicle (UGV) and an Unmanned Aerial Vehicle (UAV). More specifically, the UGV navigates through the free space, and the UAV provides enhanced situational awareness via its higher vantage point. The motivating application is search and rescue in a damaged building. A camera atop the UGV is used to track a fiducial tag on the underside of the UAV, allowing the UAV to maintain a fixed pose relative to the UGV. Furthermore, the UAV uses its front facing camera to provide a birds-eye-view to the remote …

Electroproduction Of W Mesons Off Protons In The Third Resonance Region And Beyond, Evan Phelps

Theses and Dissertations

Exclusive electroproduction of ω(782) mesons in the reaction ep → epω → epπ+π−π0 was studied from the production threshold, through the third resonance region, and beyond. With electron beam energies close to 6 GeV, the kinematic range covers W = [1.72, 2.60) GeV and Q2 = [1.85, 5.15) GeV2. By combining two sets of data collected by the Thomas Jefferson National Accelerator Facility’s wide-acceptance spectrometer (CLAS), the largest set of resonance-region differential cross sections, d2σh dΩ∗ , for ω electroproduction have been produced. Response functions RT + LRL, RTT , and RTL were extracted to provide a view of how …

Bayesian Flexible Modeling Of Interval-Censored Failure Time Data, Sheng-Yang Wang

Theses and Dissertations

Interval-censored data are a special type of survival data, in which the survival time is not accurately observed but known to fall within a specific time interval. Interval censored data commonly arise in real-life epidemiological and medical studies that involve periodic examinations. In this dissertation, several semi-parametric regression models are investigated to provide flexible modeling and robust inference for interval censored data from Bayesian perspectives.

Chapter 1 provides a detailed description about interval-censored data and gives several examples. Existing models and methods for analyzing such interval-censored data are reviewed as well. Chapter 2 develops a unified Bayesian estimation approach under …

Advances In Chemistry, Part I: Noise, Calibration, And Educational Advances In Analytical Chemistry. Part Ii: Safety Oversight In Chemical Journals, Lauren E. Grabowski

Theses and Dissertations

Part I:

The accuracy and precision of the results of any chemical analysis depends on the calibration graph and its associated systematic and random errors. Least squares regression generally treats all data with equal weights. A weighted least-squares fit is an improvement but requires knowledge of the imprecision in each point of the calibration graph. The imprecision is not easy to estimate with high confidence because of the large number of replicates needed.

The imprecision depends on the types and magnitudes of the sources of noise. We characterized the noise sources in ICP-OES and UV/Vis and developed a model that …

Antimicrobial Biomaterials And Sustainable Polymers From Renewable Biomass, Mitra Shiran Ganewatta

Theses and Dissertations

In this dissertation, development of antimicrobial biomaterials and sustainable polymers from renewable biomass is described. In Chapter 1, an overview and recent development about sustainable polymers from renewable biomass, antimicrobial biomaterials and polymerization methods are given. Afterwards, the major research objectives of this doctoral research work are described.

Innovative cationic polymers containing pine resin sourced abietic acid is discussed in Chapter 2. The preparation of cationic compounds is conversed via a combination of Diels-Alder, catalytic esterification, quaternization and subsequent decoration of polycaprolactone that was prepared via ring-opening polymerization (ROP). Furthermore, the antimicrobial activity against a range of bacteria, biocompatibility with …

Shaping Metallic Nanoparticles Toward Integrated Plasmonics And Catalysis, Qingfeng Zhang

Theses and Dissertations

Noble metal nanoparticles have been of tremendous interest because of their intriguing size- and shape-dependent plasmonic and catalytic properties. The combination of tunable plasmon resonances with superior catalytic activities on the same nanoparticle, however, has long been challenging because plasmonics and catalysis require nanoparticles in two drastically different size regimes. Tunable plasmon resonances is a unique feature of sub-wavelength metallic nanoparticles, whereas heterogeneous catalysis requires the use of sub-5 nm nanoparticles as the catalysts. In this dissertation, I firstly found a unique way to bridge this size gap between nanoplasmonics and nanocatalysis. I demonstrated that desired plasmonic and catalytic properties …

The Nano-Adventures Of Gold And Silver: An Ios Game, Elizabeth Pruett

Senior Theses

The Nano-Adventures of Gold and Silver is an iOS game intended for young students to learn about nanoscience and the benefits and harms of various nanoparticles in the environment, originally created by the Center for Environmental Nanoscience and Risk. This project exists as the first iteration of a game about two superheroes, Nano-Gold and Nano-Silver, who invite players along as they use their powers to deal with different scenarios. Over the course of a year, the game was designed, developed, and tested; the resulting application includes user authentication capabilities, an origin story detailing the Nano-Girls narrative, and a complete level, …

A Family Of Simple Codimension Two Singularities With Infinite Cohen-Macaulay Representation Type, Tyler Lewis

Theses and Dissertations

A celebrated theorem of Buchweitz, Greuel, Knörrer, and Schreyer is that the hypersurface singularities of finite representation type, i.e. the hypersurface singularities admitting only finitely many indecomposable maximal Cohen-Macaulay modules, are exactly the ADE singularities. The codimension 2 singularities that are the analogs of the ADE singularities have been classified by Frühbis-Krühger and Neumer, and it is natural to expect an analogous result holds for these singularities. In this paper, I will present a proof that, in contrast to hypersurfaces, Frühbis-Krühger and Neumer’s singularities include a subset of singularities of infinite representation type.

Semiparametric Estimation And Inference In Causal Inference And Measurement Error Models, Jianxuan Liu

Theses and Dissertations

This dissertation research has focused on theoretical and practical developments of semiparametric modeling and statistical inference for high dimensional data and measurement error data. In causal inference framework, when evaluating the effectiveness of medical treatments or social intervention policies, the average treatment effect becomes fundamentally important. We focus on propensity score modelling in treatment effect problems and develop new robust tools to overcome the curse of dimensionality. Furthermore, estimating and testing the effect of covariates of interest while accommodating many other covariates is an important problem in many scientific practices, including but not limited to empirical economics, public health and …

Subdivision Of Measures Of Squares, Dylan Bates

Theses and Dissertations

The primary goal of our work is to establish a method to relate simple measures to a given set of moments. We calculate the moments of squares via linear polynomial weight measures and straight line cuts and use this to calculate the centre of mass of the square. The one-to-one correspondence that is found is needed to represent surfaces with gaps, which can estimate arbitrary measures on squares. From this, a subdivision scheme is developed, which successively quadrisects squares and uses the relation to estimate the new measures in order to provide a good representation of the original surface. One …

A Mechanistic Study Of Micro Rna 21 Induced Hepatic Fibrosis And Use Of Sparstolonin B In Remediation Of Environmental Nafld, Diptadip Dattaroy

Theses and Dissertations

Due to the increased prevalence of obesity, non-alcoholic fatty liver disease (NAFLD) has become a major public health problem in the Western world and Asian countries. Approximately a third of the general population in the US has NAFLD. NAFLD includes a spectrum of histological characteristics ranging from simple steatosis to steatohepatitis, fibrosis and cirrhosis and can be characterized into to two major phenotypes: nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Water disinfection byproducts like trihalomethanes can act as crucial risk factors for NAFLD progression. Here I have studied the molecular mechanisms of a water disinfection byproduct, Bromodichloromethane, in induction …

Chemical Sensing In Harsh Environments By Multivariate Optical Computing, Christopher Michael Jones

Theses and Dissertations

Multivariate optical computing (MOC) is a compressive sensing technique for which an analyte concentration is detected in an interfering mixture by direct detector output. The detector measures the dot product of a linear regression vector with a sample spectrum, as an analog optical computation. The computation is accomplished with the multivariate optical element (MOE), to which the optical regression vector is encoded as a transmission pattern. As a spectrum of light emanates from a sample and passes through the MOE, the dot product naturally occurs when light strikes the detector. The MOC platform allows a simple, robust, and direct measurement …

High Resolution Gravity, Helicopter Magnetic, And Electromagnetic Study, Haile Gold Mine, South Carolina, Saad Saud Alarifi

Theses and Dissertations

The goal of this research was to calibrate and test geophysical methods for the detection of disseminated sulfides in the area of the Haile Gold Mine, South Carolina. The work focused on the calibration of high resolution gravity, and helicopter electromagnetic (EM) and magnetic data provided by OceanaGold. While high resolution potential field data (gravity and magnetics) has not been proven to be effective at small scales in exploration for disseminated sulfides, there is a strong regional correlation between high amplitude gravity and magnetic anomalies and the most productive gold mines in the Carolina terrane. Helicopter EM methods have been …

Robustness Evaluation For Phylogenetic Reconstruction Methods And Evolutionary Models Reconstruction Of Tumor Progression, Jun Zhou

Theses and Dissertations

During evolutionary history, genomes evolve by DNA mutation, genome rearrangement, duplication and gene loss events. There has been endless effort to the phylogenetic and ancestral genome inference study. Due to the great development of various technology, the information about genomes is exponentially increasing, which make it possible figure the problem out. The problem has been shown so interesting that a great number of algorithms have been developed rigorously over the past decades in attempts to tackle these problems following different kind of principles. However, difficulties and limits in performance and capacity, and also low consistency largely prevent us from confidently …

The Summerville Formation: Evidence For A Sub-Horizontal Stratigraphic Sequence Below The Post-Rift Unconformity In The Middleton Place Summerville Seismic Zone, Joseph Edward Getz

Theses and Dissertations

The Middleton Place Summerville Seismic Zone (MPSSZ) near Summerville, South Carolina was the site of renewed extensive investigation, beginning in the 1970’s, for the source of the 1886 Charleston earthquake. Reactivation of faults associated with a putative fault-bounded Triassic rift basin through analysis of seismic reflection, seismic refraction, and well data has since become the favored interpretation for the source of MPSSZ seismicity. Critical to this interpretation is the association of continental redbed sedimentary rocks in Triassic basins throughout the North American Atlantic margin. Reanalysis of 18 seismic reflection profiles and 25 seismic refraction profiles within the MPSSZ suggests that …

Sanitary Sewer Overflows In Columbia, South Carolina And Their Impact On Mercury And Metal Cycling, Alison Emmons

Theses and Dissertations

Objectives. Microbial pathogens and their threat to human health have been the primary concern of sanitary sewer overflows (SSO); however, SSOs may also be a source of metals, including methylmercury, to local waterways. We hypothesized that SSOs had elevated concentrations of metals compared to nearby reference creeks.

Methods. Unfiltered and filtered (0.2 μm) surface water samples were collected monthly between November 2015 and March 2016 from three sewage-impacted creeks in Columbia, South Carolina. During this period, three sewage events were captured including an active SSO, a ruptured force main sewer pipe, and one site downstream from SSOs. In October 2016 …

Utilizing Structure-From-Motion Photogrammetry And Unmanned Aerial Vehicles To Characterize Variability In Fluvial Deposits From The Salt Wash Member Of The Morrison Formation, East-Central Utah, John Chesley

Theses and Dissertations

Modern fluvial systems are highly variable, often containing the entire spectrum of fluvial styles (e.g., braided to meandering). This variability is difficult to capture in ancient fluvial deposits due to limited 1- and 2-dimesional exposures, which provide only a snapshot of the depositional history at one location. As a result, researchers are forced to interpolate between exposures and develop regional scale models that often underestimate the complexity and variability seen in modern environments. Outcrops of the Upper Jurassic Salt Wash Member of the Morrison Formation in east-central Utah, USA provide a relatively unique opportunity to examine ancient fluvial sandstone bodies …

Drivers Of Sediment Accumulation And Nutrient Burial In Coastal South Carolina Residential Stormwater Detention Ponds, William Schroer

Theses and Dissertations

Stormwater detention ponds are widely utilized as control structures to manage runoff waters during storm events. These sediments also represent significant sites of organic carbon and nutrient burial. Here, carbon (C) and nutrient sources and burial rates were determined in 14 residential stormwater detention ponds throughout coastal counties of South Carolina. Bulk sediment accumulation was directly correlated with catchment impervious surface coverage (R2 = 0.90) with sediment accumulation rates ranging from 0.06 to 0.50 cm y-1. These rates of sediment accumulation and subsequent pond volume loss are lower than expected indicating that required maintenance dredging schedules be reassessed. Strong, positive …

On Slowly Rotating Supercompact Schwarzschild Stars, Nelson Camilo Posada-Aguirre

Theses and Dissertations

In this Ph.D thesis, I will present results concerning to my doctoral research project submitted to the Department of Physics and Astronomy at the University of South Carolina. The thesis belongs to the area of Theoretical Physics, particularly, in the framework of Einstein’s Theory of General Relativity.

The project is the study of integral and surface properties of slowly rotating homogeneous masses in the gravastar limit R ! Rs, where Rs is the Schwarzschild radius. For this purpose we followed the perturbative method proposed by Hartle in 1967. In this model, the relativistic equations of structure for a slowly rotating …

Development Of An Electrochemical Method To Study Real-Time In Vivo Neurotransmitter Modulation, Srimal Aminda Samaranayake

Theses and Dissertations

Histamine and serotonin are important biogenic amines that regulate vital brain functions. These two transmitters are thoughts to be involved in neurodegenerative diseases such as Parkinson’s and Alzheimer’s and affective disorders including depression. Histamine and serotonin are believed to regulate each other but their fundamental neuromodulation mechanisms are not well understood. This lack of understanding makes brain disorders implicating these two transmitters difficult to diagnose and treat. Our lab extensively investigates the serotonergic system to understand serotonin’s neurochemistry in the brain. However, histamine is relatively understudied with respect to other biogenic amines because of an absence of suitable analytical tools. …

Synthesis, Characterization And Application Of Polymer-Grafted Nanoparticles, Yang Zheng

Theses and Dissertations

This work focused on the synthesis and characterization of polymer-grafted nanoparticles for various applications including drug-delivery, directed self-assembly and mechanical reinforcement applications. The surfaces of inorganic particles were modified with polymers of different composition, chain length, graft density and polymer architecture depending on the specific needs of each project. The surface modifications were mainly achieved by surface-initiated reversible addition fragmentation chain transfer (RAFT) polymerization, which is a very versatile technique to prepare nanocomposites with desired properties.

The first part of this work (Chapters 2 & 3) focused on novel self-assembly techniques. Chapter 2 described the design and characterization of a …

Serpentinization And Synthesis: Searching For Abiotic And Biotic Non-Volatile Organic Molecules In The Subsurface Of The Atlantis Massif, Katherine A. Hickok

Theses and Dissertations

High concentrations of hydrogen created during serpentinization can promote the formation of abiotic organic carbon molecules such as methane, formate, and short chain hydrocarbons and, in laboratory experiments, larger molecules containing up to 32 carbon atoms. Subsurface archaeal and bacterial communities can use these reduced compounds for metabolic energy. International Ocean Discovery Project Expedition 357 drilled 17 boreholes into the Atlantis Massif with the goals of investigating carbon cycling and the presence of life in a zone of active serpentinization. The expedition recovered multiple lithologies including gabbros, basalts, carbonate sands, and serpentinites. A subset of contrasting lithologies were analyzed for …

Geometric Influence On Electronic Properties: Graphene With Antidots, Two-Dimensional Electron Gas And Three-Dimensional Carbon Nanostructures, Lei Wang

Theses and Dissertations

Geometric influence on electrical and magneto transport properties has been investigated in three types of systems: (i) Graphene, a single layer of carbon atoms; (ii) Two-dimensional electron gas (2DEG) in AlInN/GaN heterostructure; and (iii) 3D carbon nanostructures, a special type of three-dimensional materials with spherical voids. Due to unique structures and energy dispersion relations, these three systems demonstrate distinct physical properties.

AlInN is the newest and amongst the widest band gap semiconductors. The 2DEG in AlInN/GaN heterostucture displays long transport lifetime along with conventional behaviors, including Shubnikov-de Haas (SdH) oscillation and weak localization. From SdH oscillation, the effective mass of …